Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Joaquin Espinosa

Concepts (328)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Down Syndrome
25
2025
469
7.220
Why?
Tumor Suppressor Protein p53
16
2025
508
4.270
Why?
Transcription, Genetic
12
2021
1404
2.170
Why?
Cyclin-Dependent Kinases
7
2022
130
1.990
Why?
Neoplasms
10
2025
2464
1.790
Why?
Transcriptional Activation
6
2023
356
1.650
Why?
Janus Kinase Inhibitors
2
2024
25
1.640
Why?
Chromosomes, Human, Pair 21
2
2024
42
1.540
Why?
Piperidines
2
2024
190
1.470
Why?
Pyrimidines
3
2024
445
1.390
Why?
Proteome
4
2024
430
1.380
Why?
Transcriptome
4
2024
881
1.280
Why?
Interferons
4
2023
192
1.220
Why?
Hypoxia
2
2024
1036
0.990
Why?
Antineoplastic Agents
5
2025
2051
0.960
Why?
Gene Regulatory Networks
2
2021
280
0.960
Why?
Immunoglobulins
1
2025
157
0.910
Why?
Erythropoiesis
1
2024
51
0.910
Why?
Heme
1
2024
76
0.880
Why?
Blood-Brain Barrier
1
2025
127
0.880
Why?
Receptors, Interferon
2
2023
50
0.860
Why?
Gene Expression Regulation, Neoplastic
8
2021
1351
0.830
Why?
Protein Phosphatase 2C
1
2022
15
0.820
Why?
Transcription Factors
9
2023
1628
0.770
Why?
Molecular Targeted Therapy
1
2025
385
0.760
Why?
Blood
1
2022
99
0.750
Why?
Arthritis, Psoriatic
1
2021
20
0.750
Why?
Cell Death
1
2022
348
0.720
Why?
Genes, Tumor Suppressor
1
2021
86
0.710
Why?
Oncogenes
1
2021
109
0.690
Why?
Proto-Oncogene Proteins c-mdm2
6
2025
63
0.690
Why?
Databases, Genetic
1
2021
228
0.670
Why?
Kynurenine
2
2023
105
0.670
Why?
Heart Defects, Congenital
2
2025
740
0.670
Why?
Trisomy
2
2019
77
0.660
Why?
Apoptosis
10
2023
2435
0.650
Why?
Interferon-alpha
2
2020
192
0.640
Why?
Signal Transduction
9
2024
4826
0.640
Why?
Humans
61
2025
128417
0.620
Why?
Tumor Suppressor Proteins
2
2018
313
0.610
Why?
Enhancer Elements, Genetic
1
2020
176
0.610
Why?
Cyclin-Dependent Kinase 8
6
2022
44
0.610
Why?
Metabolome
1
2021
319
0.590
Why?
Genomics
1
2021
715
0.500
Why?
Case-Control Studies
6
2025
3328
0.460
Why?
Cell Proliferation
6
2023
2344
0.460
Why?
Cell Line, Tumor
9
2023
3184
0.460
Why?
Animals
20
2025
34479
0.450
Why?
Hypoxia-Inducible Factor 1, alpha Subunit
3
2024
257
0.440
Why?
Proteomics
4
2025
1009
0.430
Why?
Carcinoma, Squamous Cell
1
2018
620
0.420
Why?
Cyclins
3
2022
85
0.400
Why?
Mice
14
2024
16602
0.400
Why?
Datasets as Topic
2
2022
109
0.370
Why?
Cell Cycle Proteins
4
2023
577
0.350
Why?
RNA Polymerase II
4
2019
317
0.350
Why?
Triple Negative Breast Neoplasms
3
2019
191
0.350
Why?
Adult
9
2025
35299
0.320
Why?
Mediator Complex
3
2022
56
0.310
Why?
Female
19
2025
68153
0.300
Why?
Gene Expression Profiling
3
2024
1688
0.300
Why?
Biomarkers
4
2025
3880
0.290
Why?
Promoter Regions, Genetic
4
2013
1198
0.280
Why?
Proto-Oncogene Proteins
2
2023
634
0.270
Why?
Gene Expression Regulation
3
2012
2505
0.270
Why?
Adolescent
6
2025
20179
0.270
Why?
Cytokines
5
2024
1983
0.260
Why?
Positive Transcriptional Elongation Factor B
1
2006
29
0.250
Why?
Cell Differentiation
2
2024
1900
0.250
Why?
Cyclin-Dependent Kinase Inhibitor p21
4
2009
114
0.250
Why?
Cell Cycle
2
2008
581
0.250
Why?
Lung Neoplasms
1
2018
2328
0.250
Why?
Metabolomics
2
2021
599
0.240
Why?
Phosphorylation
4
2022
1681
0.240
Why?
Male
11
2025
62857
0.240
Why?
Protein Binding
5
2021
2103
0.230
Why?
Hemoglobin SC Disease
1
2023
13
0.220
Why?
Young Adult
4
2025
12312
0.220
Why?
Erythropoietin
1
2024
84
0.210
Why?
Homeodomain Proteins
2
2019
490
0.210
Why?
Oxidative Phosphorylation
1
2024
184
0.210
Why?
Glutamine
1
2023
92
0.210
Why?
Liposarcoma
1
2023
27
0.210
Why?
Cell Line
4
2019
2731
0.210
Why?
Alzheimer Disease
2
2020
516
0.210
Why?
Cyclin C
1
2022
2
0.210
Why?
Eukaryotic Initiation Factor-2
1
2022
26
0.200
Why?
Diabetic Neuropathies
1
2023
90
0.200
Why?
Child, Preschool
4
2025
10384
0.200
Why?
Growth Disorders
1
2022
80
0.200
Why?
Centrosome
2
2022
64
0.200
Why?
Gene Silencing
1
2023
185
0.190
Why?
Cerebellar Neoplasms
1
2023
156
0.190
Why?
DNA-Binding Proteins
3
2016
1421
0.190
Why?
Medulloblastoma
1
2023
198
0.190
Why?
Acetyltransferases
1
2001
22
0.180
Why?
Stress, Physiological
1
2024
410
0.180
Why?
Doxorubicin
3
2007
322
0.180
Why?
Hematopoiesis
2
2021
185
0.180
Why?
Access to Information
1
2021
47
0.180
Why?
Janus Kinase 1
1
2020
24
0.180
Why?
Cilia
2
2022
179
0.180
Why?
Janus Kinase 2
1
2020
32
0.180
Why?
Azetidines
1
2020
40
0.180
Why?
Models, Biological
1
2008
1691
0.170
Why?
RNA, Messenger
3
2021
2675
0.170
Why?
Up-Regulation
2
2021
825
0.170
Why?
Flow Cytometry
2
2019
1142
0.170
Why?
Insulin-Like Growth Factor I
1
2022
307
0.170
Why?
Data Mining
1
2021
109
0.170
Why?
MicroRNAs
2
2018
677
0.170
Why?
Nuclear Proteins
3
2023
657
0.170
Why?
Anemia, Sickle Cell
1
2023
252
0.170
Why?
Quinolinic Acid
1
2019
8
0.170
Why?
Eosinophilic Esophagitis
1
2024
318
0.170
Why?
Child
6
2025
20655
0.170
Why?
Connective Tissue Diseases
1
2020
81
0.170
Why?
Biosynthetic Pathways
1
2019
23
0.160
Why?
Heart Diseases
1
2023
345
0.160
Why?
Indoleamine-Pyrrole 2,3,-Dioxygenase
1
2019
52
0.160
Why?
Protein Domains
2
2017
252
0.160
Why?
Mice, Inbred C57BL
5
2020
5272
0.150
Why?
Coinfection
1
2020
131
0.150
Why?
Middle Aged
5
2025
30889
0.150
Why?
Genome, Human
1
2021
391
0.150
Why?
Calcinosis
1
2020
230
0.150
Why?
Nedd4 Ubiquitin Protein Ligases
1
2018
15
0.150
Why?
SOXB1 Transcription Factors
1
2019
58
0.150
Why?
Transforming Growth Factor beta2
1
2018
32
0.150
Why?
Forkhead Box Protein O3
1
2018
15
0.150
Why?
Epithelial Cells
1
2024
1032
0.150
Why?
TOR Serine-Threonine Kinases
1
2021
380
0.150
Why?
rhoA GTP-Binding Protein
1
2018
90
0.150
Why?
Bacterial Infections
1
2020
226
0.150
Why?
Inflammation
2
2020
2654
0.150
Why?
Stem Cell Niche
1
2018
51
0.150
Why?
Receptor, Notch1
1
2018
61
0.140
Why?
Inpatients
1
2022
465
0.140
Why?
Cell Survival
1
2021
1077
0.140
Why?
Autoimmunity
1
2023
860
0.140
Why?
Binding Sites
3
2014
1236
0.140
Why?
Hypersensitivity
1
2020
249
0.140
Why?
Apoptosis Regulatory Proteins
1
2018
182
0.140
Why?
Leukemia, Biphenotypic, Acute
1
2017
3
0.140
Why?
Hedgehog Proteins
1
2018
187
0.140
Why?
Protein Kinase Inhibitors
2
2020
872
0.130
Why?
Sulfonamides
1
2020
499
0.130
Why?
T-Lymphocytes
2
2022
1923
0.130
Why?
Histidine Kinase
1
2016
33
0.130
Why?
Osteosarcoma
1
2017
72
0.130
Why?
Antigens
1
2018
353
0.130
Why?
Exosomes
1
2017
96
0.130
Why?
Chromatin
4
2016
477
0.130
Why?
Proteolysis
1
2017
162
0.130
Why?
Interferon-gamma
1
2019
759
0.130
Why?
Neoplasm Recurrence, Local
2
2019
958
0.130
Why?
Adenosine Triphosphatases
1
2016
161
0.120
Why?
HCT116 Cells
3
2019
78
0.120
Why?
Colonic Neoplasms
1
2018
242
0.120
Why?
Ribosomal Proteins
1
2015
77
0.120
Why?
Autophagy
1
2018
265
0.120
Why?
Disease Models, Animal
2
2023
3937
0.120
Why?
Hematopoietic Stem Cells
1
2018
378
0.120
Why?
Nerve Tissue Proteins
1
2019
567
0.120
Why?
Bone Neoplasms
1
2017
229
0.120
Why?
Phenotype
1
2023
3044
0.120
Why?
Azepines
1
2015
88
0.120
Why?
Neoplastic Stem Cells
1
2019
386
0.110
Why?
Gene Expression
1
2019
1456
0.110
Why?
Fibroblasts
1
2019
935
0.110
Why?
Repressor Proteins
1
2017
399
0.110
Why?
Carrier Proteins
1
2018
732
0.110
Why?
Acetylation
2
2007
237
0.110
Why?
ets-Domain Protein Elk-1
1
2013
13
0.110
Why?
Mitogens
1
2013
58
0.110
Why?
Disease Progression
1
2021
2602
0.110
Why?
Down-Regulation
1
2015
631
0.110
Why?
Prospective Studies
1
2025
7036
0.100
Why?
Extracellular Signal-Regulated MAP Kinases
1
2013
163
0.100
Why?
Feedback, Physiological
1
2012
74
0.100
Why?
Tumor Cells, Cultured
3
2019
930
0.100
Why?
Hypertension, Pulmonary
1
2023
1745
0.100
Why?
RNA Stability
1
2012
100
0.100
Why?
Protein Structure, Tertiary
2
2006
835
0.090
Why?
Sirtuins
1
2010
37
0.080
Why?
HeLa Cells
3
2013
603
0.080
Why?
Histones
2
2007
586
0.080
Why?
Intracellular Signaling Peptides and Proteins
2
2023
431
0.080
Why?
S Phase
1
2009
73
0.080
Why?
Diabetes Mellitus, Type 2
1
2023
2429
0.080
Why?
Protamine Kinase
1
2008
8
0.080
Why?
Enzyme Activation
2
2008
799
0.080
Why?
Receptors, Thyroid Hormone
1
2008
21
0.080
Why?
Hydroxyurea
2
2023
31
0.070
Why?
RNA
1
2014
880
0.070
Why?
Multiprotein Complexes
1
2008
147
0.070
Why?
DNA Topoisomerases, Type II
1
2007
43
0.070
Why?
Formaldehyde
1
2007
57
0.070
Why?
Radiation, Ionizing
1
2007
75
0.070
Why?
Genome-Wide Association Study
2
2025
1336
0.070
Why?
Glycolysis
2
2024
293
0.070
Why?
Protein Kinases
1
2009
309
0.070
Why?
RNA Precursors
1
2007
147
0.070
Why?
Fluorouracil
1
2007
197
0.070
Why?
Transcription Factors, TFII
1
2006
40
0.060
Why?
Kinetics
2
2007
1615
0.060
Why?
High Mobility Group Proteins
1
2006
42
0.060
Why?
Transcriptional Elongation Factors
1
2006
36
0.060
Why?
Transcription Factor TFIIH
1
2006
40
0.060
Why?
Breast Neoplasms
1
2018
2132
0.060
Why?
Chromatin Immunoprecipitation
1
2006
131
0.060
Why?
Protein Transport
1
2007
420
0.060
Why?
Mice, Knockout
3
2019
2755
0.060
Why?
Serine
1
2006
135
0.060
Why?
Glucose
1
2010
982
0.060
Why?
Protein Isoforms
1
2006
378
0.060
Why?
Xenograft Model Antitumor Assays
2
2019
814
0.060
Why?
Hemoglobin, Sickle
1
2023
18
0.060
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2006
940
0.050
Why?
Glutamates
1
2023
56
0.050
Why?
Intermediate Filaments
1
2023
27
0.050
Why?
Activating Transcription Factor 4
1
2023
20
0.050
Why?
Proteasome Inhibitors
1
2023
44
0.050
Why?
L-Selectin
1
2023
24
0.050
Why?
Proline
1
2023
76
0.050
Why?
Neurofilament Proteins
1
2023
44
0.050
Why?
Perforin
1
2023
19
0.050
Why?
Tyrosine
1
2023
217
0.050
Why?
Patient Acuity
1
2023
45
0.050
Why?
Proteasome Endopeptidase Complex
1
2023
145
0.050
Why?
Protein Tyrosine Phosphatases
1
2023
168
0.050
Why?
Esophagus
1
2024
248
0.050
Why?
Bile Acids and Salts
1
2023
194
0.050
Why?
Hemolysis
1
2023
199
0.050
Why?
Centrioles
1
2022
41
0.050
Why?
DNA Footprinting
1
2001
33
0.050
Why?
Cytoskeletal Proteins
1
2022
142
0.050
Why?
Neuroimaging
1
2024
278
0.050
Why?
p300-CBP Transcription Factors
1
2001
21
0.050
Why?
Immunoblotting
1
2001
300
0.040
Why?
Clonal Evolution
1
2021
38
0.040
Why?
Histone Acetyltransferases
1
2001
63
0.040
Why?
Germ-Line Mutation
1
2020
138
0.040
Why?
Cells, Cultured
2
2018
4001
0.040
Why?
Heterozygote
1
2020
267
0.040
Why?
Toll-Like Receptors
1
2020
179
0.040
Why?
Interferon Type I
1
2020
140
0.040
Why?
Genetic Testing
1
2022
428
0.040
Why?
Vesiculovirus
1
2019
16
0.040
Why?
Purines
1
2020
169
0.040
Why?
Microtubules
1
2022
259
0.040
Why?
Antigens, Neoplasm
1
2022
309
0.040
Why?
Immunotherapy
1
2024
587
0.040
Why?
Immunotherapy, Adoptive
1
2022
295
0.040
Why?
STAT1 Transcription Factor
1
2019
70
0.040
Why?
Drosophila melanogaster
1
2001
217
0.040
Why?
Heart
1
2023
635
0.040
Why?
Nanog Homeobox Protein
1
2019
13
0.040
Why?
Risk Factors
2
2025
9704
0.040
Why?
DNA
1
2006
1390
0.040
Why?
Myelopoiesis
1
2018
7
0.040
Why?
Lymphopoiesis
1
2018
26
0.040
Why?
Recombinant Fusion Proteins
1
2001
634
0.040
Why?
Mice, 129 Strain
1
2018
79
0.040
Why?
Mice, SCID
1
2019
350
0.040
Why?
MCF-7 Cells
1
2018
115
0.040
Why?
Receptors, Growth Factor
1
2017
46
0.040
Why?
Amyloid beta-Peptides
1
2020
211
0.040
Why?
Polymorphism, Single Nucleotide
1
2025
2062
0.040
Why?
Pyrazoles
1
2020
404
0.030
Why?
Ubiquitin-Conjugating Enzymes
1
2017
13
0.030
Why?
Mice, Inbred NOD
1
2019
586
0.030
Why?
Interleukin-1 Receptor-Associated Kinases
1
2017
27
0.030
Why?
CD8-Positive T-Lymphocytes
1
2023
846
0.030
Why?
Genetic Predisposition to Disease
1
2025
2264
0.030
Why?
CD4-Positive T-Lymphocytes
1
2023
1046
0.030
Why?
Neoplasm Metastasis
1
2019
608
0.030
Why?
Host-Pathogen Interactions
1
2019
346
0.030
Why?
Mitosis
1
2017
178
0.030
Why?
Imidazoles
1
2017
226
0.030
Why?
Myeloid-Lymphoid Leukemia Protein
1
2017
71
0.030
Why?
Mice, Inbred BALB C
1
2019
1228
0.030
Why?
Tumor Protein p73
1
2015
14
0.030
Why?
Cholesterol
1
2017
406
0.030
Why?
Receptors, Estrogen
1
2018
424
0.030
Why?
Histone-Lysine N-Methyltransferase
1
2017
125
0.030
Why?
Aurora Kinase A
1
2015
55
0.030
Why?
Piperazines
1
2017
336
0.030
Why?
Immunity, Innate
1
2020
802
0.030
Why?
Complement System Proteins
1
2017
307
0.030
Why?
Survival Rate
1
2019
1869
0.030
Why?
Genes, Immediate-Early
1
2013
18
0.030
Why?
Cell Movement
1
2018
936
0.030
Why?
Protein Conformation
1
2016
852
0.030
Why?
Genes, ras
1
2013
98
0.030
Why?
NIH 3T3 Cells
1
2013
141
0.030
Why?
B-Lymphocytes
1
2018
817
0.030
Why?
Interleukin-1
1
2017
961
0.030
Why?
Liver
1
2020
1826
0.020
Why?
Biomarkers, Tumor
1
2019
1181
0.020
Why?
Chronic Disease
1
2017
1705
0.020
Why?
HEK293 Cells
1
2013
683
0.020
Why?
Prognosis
1
2019
3772
0.020
Why?
Cell Respiration
1
2010
98
0.020
Why?
Glucose Transporter Type 1
1
2010
48
0.020
Why?
Follow-Up Studies
1
2019
4892
0.020
Why?
Daunorubicin
1
2009
25
0.020
Why?
Checkpoint Kinase 2
1
2009
23
0.020
Why?
Nucleic Acid Synthesis Inhibitors
1
2009
16
0.020
Why?
Checkpoint Kinase 1
1
2009
31
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2009
64
0.020
Why?
Caffeine
1
2009
61
0.020
Why?
Coenzymes
1
2008
17
0.020
Why?
Glyceraldehyde-3-Phosphate Dehydrogenases
1
2007
12
0.020
Why?
RNA Caps
1
2007
31
0.020
Why?
Substrate Specificity
1
2008
365
0.020
Why?
Genes, myc
1
2007
50
0.020
Why?
Poly A
1
2007
48
0.020
Why?
Topoisomerase II Inhibitors
1
2007
24
0.020
Why?
DNA Replication
1
2009
225
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2007
281
0.020
Why?
Retrospective Studies
1
2024
14454
0.020
Why?
Mass Spectrometry
1
2008
659
0.020
Why?
Recombinant Proteins
1
2008
1281
0.020
Why?
Infant
1
2017
8914
0.010
Why?
Myocytes, Cardiac
1
2007
492
0.010
Why?
Mutation
1
2013
3689
0.010
Why?
Models, Molecular
1
2007
1480
0.010
Why?
Espinosa's Networks
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