 Transforming Growth Factor beta2
"Transforming Growth Factor beta2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
| Descriptor ID |
D053781
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| MeSH Number(s) |
D12.644.276.374.687.200 D12.644.276.954.775.200 D12.776.467.374.687.200 D12.776.467.942.775.200 D23.529.374.687.200 D23.529.942.775.200
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| Concept/Terms |
Transforming Growth Factor beta2- Transforming Growth Factor beta2
- Glioblastoma-Derived T-Cell Suppressor Factor
- Glioblastoma Derived T Cell Suppressor Factor
- Cartilage-Inducing Factor-B
- Cartilage Inducing Factor B
- Polyergin
- TGF-beta2
- TGF-beta-2
- BSC-1 Cell Growth Inhibitor
- BSC 1 Cell Growth Inhibitor
- Suppressor Factor, T-Cell, Glioblastoma-Derived
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta2".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta2".
This graph shows the total number of publications written about "Transforming Growth Factor beta2" by people in this website by year, and whether "Transforming Growth Factor beta2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 | | 2006 | 2 | 0 | 2 | | 2007 | 0 | 1 | 1 | | 2012 | 3 | 0 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 3 | 0 | 3 | | 2018 | 3 | 1 | 4 | | 2019 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta2" by people in Profiles.
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Nam MH, Pantcheva MB, Rankenberg J, Nagaraj RH. Transforming growth factor-?2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE. Biochem J. 2021 06 25; 478(12):2285-2296.
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Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San Jos? Est?par R, Zhou X, Castaldi PJ. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 07 25; 8.
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Sakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK. Genome-Wide Association Analysis of Single-Breath DlCO. Am J Respir Cell Mol Biol. 2019 05; 60(5):523-531.
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Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. TGF-?2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-? and inhibin-a. J Biol Chem. 2019 03 01; 294(9):3065-3080.
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Abraham CG, Ludwig MP, Andrysik Z, Pandey A, Joshi M, Galbraith MD, Sullivan KD, Espinosa JM. ?Np63a Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Cell Rep. 2018 09 18; 24(12):3224-3236.
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Nahomi RB, Nagaraj RH. The role of HIF-1a in the TGF-?2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells. J Cell Biochem. 2018 08; 119(8):6814-6827.
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Nam MH, Nagaraj RH. Matrix-bound AGEs enhance TGF?2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation. Biochem J. 2018 04 23; 475(8):1427-1440.
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Chang KC, Shieh B, Petrash JM. Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chem Biol Interact. 2017 Oct 01; 276:149-154.
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Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 08; 33(4):631-43.
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Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-?2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 05 15; 473(10):1455-69.
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