 Protein Conformation
"Protein Conformation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
| Descriptor ID |
D011487
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| MeSH Number(s) |
G02.111.570.820.709
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| Concept/Terms |
Protein Conformation- Protein Conformation
- Conformation, Protein
- Conformations, Protein
- Protein Conformations
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Below are MeSH descriptors whose meaning is more general than "Protein Conformation".
Below are MeSH descriptors whose meaning is more specific than "Protein Conformation".
This graph shows the total number of publications written about "Protein Conformation" by people in this website by year, and whether "Protein Conformation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 9 | 11 | | 1997 | 2 | 18 | 20 | | 1998 | 7 | 17 | 24 | | 1999 | 4 | 16 | 20 | | 2000 | 0 | 16 | 16 | | 2001 | 1 | 21 | 22 | | 2002 | 0 | 29 | 29 | | 2003 | 2 | 30 | 32 | | 2004 | 0 | 21 | 21 | | 2005 | 4 | 31 | 35 | | 2006 | 5 | 30 | 35 | | 2007 | 0 | 21 | 21 | | 2008 | 3 | 25 | 28 | | 2009 | 5 | 30 | 35 | | 2010 | 2 | 21 | 23 | | 2011 | 4 | 20 | 24 | | 2012 | 1 | 26 | 27 | | 2013 | 4 | 29 | 33 | | 2014 | 1 | 27 | 28 | | 2015 | 1 | 28 | 29 | | 2016 | 2 | 25 | 27 | | 2017 | 1 | 30 | 31 | | 2018 | 3 | 32 | 35 | | 2019 | 3 | 23 | 26 | | 2020 | 1 | 17 | 18 | | 2021 | 1 | 26 | 27 | | 2022 | 0 | 4 | 4 | | 2023 | 1 | 4 | 5 | | 2024 | 0 | 6 | 6 | | 2025 | 0 | 8 | 8 | | 2026 | 0 | 3 | 3 |
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Below are the most recent publications written about "Protein Conformation" by people in Profiles.
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Ye N, Del Rio Flores A, Zhang W, Drennan CL. A highly dynamic mononuclear non-heme iron enzyme for the two-step isonitrile biosynthesis. Nat Commun. 2026 01 26; 17(1).
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Bai X, Zhang J, Wang S, Huang K, Pan Z, Liang A, Wu W, Yu Z, Chen Y, Tong Y, Dai S, Chen Z. Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11's role in cooperative recognition of diverse targets. Nucleic Acids Res. 2026 Jan 22; 54(3).
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Fuchs HA, Peng Y, Ayyapan S, Rosas R, Zhang H, Panchenko AR, Musselman CA. G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails. Nucleic Acids Res. 2026 Jan 14; 54(2).
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Bhattacharjee B, Noviello CM, Rahman MM, Mayer JP, Gajewiak J, McIntosh JM, Hibbs RE, Stowell MHB. Shape-shifting conotoxins reveal divergent pore-targeting mechanisms in nicotinic receptors. Structure. 2026 Mar 05; 34(3):463-470.e4.
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Morgan RT, Motta S, Gil-Iturbe E, Bhattacharjee B, Anwar MT, Di Muccio G, Romagnoli A, Mishra B, Ashraf KU, Bang I, Di Marino D, Lowary TL, Quick M, Petrou VI, Stowell MHB, Nygaard R, Mancia F. Mechanistic snapshots of lipid-linked sugar transfer. Nat Commun. 2025 Dec 06; 16(1):11044.
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Brown CN, Vuong TT, Weigle AT, Chou YJ, Rao Q, Ebmeier CC, Dupre RA, Boue SM, Smith B, Mattison CP. Phenylglyoxal-induced Ana o 3 Modification Reduces Antibody Binding with Minimal Alteration in Protein Structure. J Agric Food Chem. 2025 Oct 01; 73(39):25043-25056.
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Wu J, Wan C, Tian Y, Ouyang Y, Puscher H, Li S, Yin Q, Shen J. Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism. Sci Adv. 2025 Sep 12; 11(37):eadw9158.
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Sardar M, Ahmad N, Mushtaq M, Heinz H, Nur-E-Alam M, Ul-Haq Z. Unveiling Ligand-Induced Conformational Changes in Mutant AR-LBD: Molecular Dynamics Insights into the Androgen Receptor-Coactivator Mechanism. J Chem Inf Model. 2025 Sep 08; 65(17):9154-9176.
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Briganti L, Annamalai AS, Bester SM, Wei G, Andino-Moncada JR, Singh SP, Kleinpeter AB, Tripathi M, Nguyen B, Radhakrishnan R, Singh PK, Greenwood J, Schope LI, Haney R, Huang S-W, Freed EO, Engelman AN, Francis AC, Kvaratskhelia M. Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir. mBio. 2025 May 14; 16(5):e0361324.
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Lee E, Tran N, Redzic JS, Singh H, Alamillo L, Holyoak T, Hamelberg D, Eisenmesser EZ. Identifying and controlling inactive and active conformations of a serine protease. Sci Adv. 2025 Apr 11; 11(15):eadu7447.
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