 Protein Conformation
"Protein Conformation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
| Descriptor ID |
D011487
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| MeSH Number(s) |
G02.111.570.820.709
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| Concept/Terms |
Protein Conformation- Protein Conformation
- Conformation, Protein
- Conformations, Protein
- Protein Conformations
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Below are MeSH descriptors whose meaning is more general than "Protein Conformation".
Below are MeSH descriptors whose meaning is more specific than "Protein Conformation".
This graph shows the total number of publications written about "Protein Conformation" by people in this website by year, and whether "Protein Conformation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 3 | 4 | | 1996 | 2 | 9 | 11 | | 1997 | 2 | 17 | 19 | | 1998 | 7 | 17 | 24 | | 1999 | 4 | 16 | 20 | | 2000 | 0 | 17 | 17 | | 2001 | 1 | 21 | 22 | | 2002 | 0 | 30 | 30 | | 2003 | 2 | 30 | 32 | | 2004 | 0 | 21 | 21 | | 2005 | 4 | 31 | 35 | | 2006 | 5 | 30 | 35 | | 2007 | 0 | 22 | 22 | | 2008 | 3 | 24 | 27 | | 2009 | 5 | 31 | 36 | | 2010 | 1 | 21 | 22 | | 2011 | 4 | 20 | 24 | | 2012 | 1 | 28 | 29 | | 2013 | 3 | 30 | 33 | | 2014 | 1 | 27 | 28 | | 2015 | 1 | 28 | 29 | | 2016 | 2 | 28 | 30 | | 2017 | 1 | 31 | 32 | | 2018 | 3 | 33 | 36 | | 2019 | 3 | 21 | 24 | | 2020 | 1 | 18 | 19 | | 2021 | 1 | 24 | 25 | | 2022 | 0 | 4 | 4 | | 2023 | 1 | 4 | 5 | | 2024 | 0 | 6 | 6 | | 2025 | 0 | 6 | 6 |
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Below are the most recent publications written about "Protein Conformation" by people in Profiles.
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Brown CN, Vuong TT, Weigle AT, Chou YJ, Rao Q, Ebmeier CC, Dupre RA, Boue SM, Smith B, Mattison CP. Phenylglyoxal-induced Ana o 3 Modification Reduces Antibody Binding with Minimal Alteration in Protein Structure. J Agric Food Chem. 2025 Oct 01; 73(39):25043-25056.
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Wu J, Wan C, Tian Y, Ouyang Y, Puscher H, Li S, Yin Q, Shen J. Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism. Sci Adv. 2025 Sep 12; 11(37):eadw9158.
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Sardar M, Ahmad N, Mushtaq M, Heinz H, Nur-E-Alam M, Ul-Haq Z. Unveiling Ligand-Induced Conformational Changes in Mutant AR-LBD: Molecular Dynamics Insights into the Androgen Receptor-Coactivator Mechanism. J Chem Inf Model. 2025 Sep 08; 65(17):9154-9176.
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Briganti L, Annamalai AS, Bester SM, Wei G, Andino-Moncada JR, Singh SP, Kleinpeter AB, Tripathi M, Nguyen B, Radhakrishnan R, Singh PK, Greenwood J, Schope LI, Haney R, Huang S-W, Freed EO, Engelman AN, Francis AC, Kvaratskhelia M. Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir. mBio. 2025 May 14; 16(5):e0361324.
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Lee E, Tran N, Redzic JS, Singh H, Alamillo L, Holyoak T, Hamelberg D, Eisenmesser EZ. Identifying and controlling inactive and active conformations of a serine protease. Sci Adv. 2025 Apr 11; 11(15):eadu7447.
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Lietzke EE, Saeb D, Aldrich EC, Bruce KD, Sprenger KG. Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology. Alzheimers Dement. 2025 Apr; 21(4):e70120.
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Lee E, Redzic JS, Eisenmesser EZ. Evolutionary Adaptations in Biliverdin Reductase B: Insights into Coenzyme Dynamics and Catalytic Efficiency. Int J Mol Sci. 2024 Dec 10; 25(24).
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Licht JA, Berry SP, Gutierrez MA, Gaudet R. They all rock: A systematic comparison of conformational movements in LeuT-fold transporters. Structure. 2024 09 05; 32(9):1528-1543.e3.
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Briganti L, Manzine LR, de Mello Capetti CC, de Araújo EA, de Oliveira Arnoldi Pellegrini V, Guimaraes FEG, de Oliveira Neto M, Polikarpov I. Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies. Int J Biol Macromol. 2024 Aug; 274(Pt 2):133182.
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Anderson JW, Vaisar D, Jones DN, Pegram LM, Vigers GP, Chen H, Moffat JG, Ahn NG. Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife. 2024 Mar 27; 12.
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