 Substrate Specificity
"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
|
| MeSH Number(s) |
G02.111.835
|
| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
|
Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 5 | 5 | | 1995 | 0 | 8 | 8 | | 1996 | 0 | 12 | 12 | | 1997 | 0 | 12 | 12 | | 1998 | 0 | 7 | 7 | | 1999 | 0 | 9 | 9 | | 2000 | 0 | 10 | 10 | | 2001 | 0 | 7 | 7 | | 2002 | 0 | 10 | 10 | | 2003 | 0 | 12 | 12 | | 2004 | 0 | 11 | 11 | | 2005 | 0 | 10 | 10 | | 2006 | 0 | 12 | 12 | | 2007 | 0 | 16 | 16 | | 2008 | 0 | 13 | 13 | | 2009 | 0 | 19 | 19 | | 2010 | 0 | 10 | 10 | | 2011 | 0 | 9 | 9 | | 2012 | 0 | 9 | 9 | | 2013 | 0 | 10 | 10 | | 2014 | 0 | 6 | 6 | | 2015 | 0 | 5 | 5 | | 2016 | 0 | 7 | 7 | | 2017 | 0 | 6 | 6 | | 2018 | 0 | 9 | 9 | | 2019 | 1 | 4 | 5 | | 2020 | 0 | 9 | 9 | | 2021 | 0 | 3 | 3 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
-
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andr?e-Busch N, K?ufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 01; 613(7945):759-766.
-
Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 10 21; 11(10):3318-3329.
-
Copley SD, Newton MS, Widney KA. How to Recruit a Promiscuous Enzyme to Serve a New Function. Biochemistry. 2023 01 17; 62(2):300-308.
-
Cleland NRW, Al-Juboori SI, Dobrinskikh E, Bruce KD. Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging. J Neuroinflammation. 2021 Oct 28; 18(1):248.
-
Basu S, Mak T, Ulferts R, Wu M, Deegan T, Fujisawa R, Tan KW, Lim CT, Basier C, Canal B, Curran JF, Drury LS, McClure AW, Roberts EL, Weissmann F, Zeisner TU, Beale R, Cowling VH, Howell M, Labib K, Diffley JFX. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. Biochem J. 2021 07 16; 478(13):2481-2497.
-
Kuatsjah E, Chan ACK, Katahira R, Haugen SJ, Beckham GT, Murphy MEP, Eltis LD. Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J Biol Chem. 2021 Jan-Jun; 296:100758.
-
Zatopek KM, Alpaslan E, Evans TC, Sauguet L, Gardner AF. Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases. Nucleic Acids Res. 2020 12 02; 48(21):12204-12218.
-
Fetherolf MM, Levy-Booth DJ, Navas LE, Liu J, Grigg JC, Wilson A, Katahira R, Beckham GT, Mohn WW, Eltis LD. Characterization of alkylguaiacol-degrading cytochromes P450 for the biocatalytic valorization of lignin. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25771-25778.
-
Knott BC, Erickson E, Allen MD, Gado JE, Graham R, Kearns FL, Pardo I, Topuzlu E, Anderson JJ, Austin HP, Dominick G, Johnson CW, Rorrer NA, Szostkiewicz CJ, Copi? V, Payne CM, Woodcock HL, Donohoe BS, Beckham GT, McGeehan JE. Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25476-25485.
-
Wang Y, Liu KF, Yang Y, Davis I, Liu A. Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19720-19730.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|