 Substrate Specificity
"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
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| MeSH Number(s) |
G02.111.835
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| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
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Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 11 | 11 | | 1997 | 0 | 12 | 12 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 8 | 8 | | 2000 | 0 | 13 | 13 | | 2001 | 0 | 8 | 8 | | 2002 | 0 | 14 | 14 | | 2003 | 0 | 11 | 11 | | 2004 | 0 | 10 | 10 | | 2005 | 0 | 11 | 11 | | 2006 | 1 | 13 | 14 | | 2007 | 0 | 16 | 16 | | 2008 | 0 | 13 | 13 | | 2009 | 0 | 17 | 17 | | 2010 | 0 | 12 | 12 | | 2011 | 0 | 9 | 9 | | 2012 | 0 | 8 | 8 | | 2013 | 0 | 11 | 11 | | 2014 | 0 | 9 | 9 | | 2015 | 0 | 4 | 4 | | 2016 | 0 | 6 | 6 | | 2017 | 0 | 7 | 7 | | 2018 | 0 | 11 | 11 | | 2019 | 1 | 4 | 5 | | 2020 | 0 | 10 | 10 | | 2021 | 0 | 5 | 5 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 0 | 4 | 4 | | 2025 | 0 | 3 | 3 | | 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
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Shirakawa KT, Parikh T, Machado LESF, Poimenidou G, Nguyen HT, Dell'Acqua ML, Kettenbach AN, Page R, Peti W. The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment. Nat Commun. 2026 Feb 16; 17(1).
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Ye N, Del Rio Flores A, Zhang W, Drennan CL. A highly dynamic mononuclear non-heme iron enzyme for the two-step isonitrile biosynthesis. Nat Commun. 2026 01 26; 17(1).
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Laviad-Shitrit S, Kon H, Bychenko Banyas D, Efrati Epchtien R, Bechor M, Lurie-Weinberger M, Ben-Zeev E, Frank S, Rakovitsky N, Schwartz D, Keren-Paz A, Carmeli Y. A single amino acid substitution in SED-2 ß-lactamase leads to increased inhibitor resistance and an extended substrate spectrum. Microbiol Spectr. 2025 Dec 02; 13(12):e0022425.
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Andrzejewski SJ, Friedman AJ, Mains K, Thompson A, Hamel NL, Sankaran B, Zwart PH, Shirts MR, Fox JM. Protein-Protein Complex Stability Controls Substrate Scope in a ß-Ketoacyl-ACP Reductase Specific for Medium Chains. Angew Chem Int Ed Engl. 2025 Sep 26; 64(40):e202508316.
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Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS. Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. EMBO Rep. 2025 Mar; 26(6):1647-1669.
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Christensen PM, Martin J, Uppuluri A, Joyce LR, Wei Y, Guan Z, Morcos F, Palmer KL. Lipid discovery enabled by sequence statistics and machine learning. Elife. 2024 Dec 10; 13.
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Del Rio Flores A, Khosla C. Characterization of the Flavin-Dependent Monooxygenase Involved in the Biosynthesis of the Nocardiosis-Associated Polyketide?. Biochemistry. 2024 11 05; 63(21):2868-2877.
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Briganti L, Manzine LR, de Mello Capetti CC, de Araújo EA, de Oliveira Arnoldi Pellegrini V, Guimaraes FEG, de Oliveira Neto M, Polikarpov I. Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies. Int J Biol Macromol. 2024 Aug; 274(Pt 2):133182.
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Brunecky R, Knott BC, Subramanian V, Linger JG, Beckham GT, Amore A, Taylor LE, Vander Wall TA, Lunin VV, Zheng F, Garrido M, Schuster L, Fulk EM, Farmer S, Himmel ME, Decker SR. Engineering of glycoside hydrolase family 7 cellobiohydrolases directed by natural diversity screening. J Biol Chem. 2024 03; 300(3):105749.
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Baljinnyam T, Conrad JW, Sowers ML, Chang-Gu B, Herring JL, Hackfeld LC, Zhang K, Sowers LC. Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing. Chem Res Toxicol. 2023 02 20; 36(2):162-176.
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