 Substrate Specificity
"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
|
| MeSH Number(s) |
G02.111.835
|
| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
|
Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 9 | 9 | | 1996 | 0 | 11 | 11 | | 1997 | 0 | 12 | 12 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 8 | 8 | | 2000 | 0 | 11 | 11 | | 2001 | 0 | 8 | 8 | | 2002 | 0 | 14 | 14 | | 2003 | 0 | 11 | 11 | | 2004 | 0 | 10 | 10 | | 2005 | 0 | 11 | 11 | | 2006 | 1 | 13 | 14 | | 2007 | 0 | 16 | 16 | | 2008 | 0 | 14 | 14 | | 2009 | 0 | 18 | 18 | | 2010 | 0 | 11 | 11 | | 2011 | 0 | 9 | 9 | | 2012 | 0 | 7 | 7 | | 2013 | 0 | 11 | 11 | | 2014 | 0 | 9 | 9 | | 2015 | 0 | 4 | 4 | | 2016 | 0 | 7 | 7 | | 2017 | 0 | 7 | 7 | | 2018 | 0 | 11 | 11 | | 2019 | 1 | 4 | 5 | | 2020 | 0 | 9 | 9 | | 2021 | 0 | 4 | 4 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 0 | 3 | 3 | | 2025 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
-
Andrzejewski SJ, Friedman AJ, Mains K, Thompson A, Hamel NL, Sankaran B, Zwart PH, Shirts MR, Fox JM. Protein-Protein Complex Stability Controls Substrate Scope in a ß-Ketoacyl-ACP Reductase Specific for Medium Chains. Angew Chem Int Ed Engl. 2025 Sep 26; 64(40):e202508316.
-
Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS. Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. EMBO Rep. 2025 Mar; 26(6):1647-1669.
-
Christensen PM, Martin J, Uppuluri A, Joyce LR, Wei Y, Guan Z, Morcos F, Palmer KL. Lipid discovery enabled by sequence statistics and machine learning. Elife. 2024 Dec 10; 13.
-
Briganti L, Manzine LR, de Mello Capetti CC, de Araújo EA, de Oliveira Arnoldi Pellegrini V, Guimaraes FEG, de Oliveira Neto M, Polikarpov I. Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies. Int J Biol Macromol. 2024 Aug; 274(Pt 2):133182.
-
Brunecky R, Knott BC, Subramanian V, Linger JG, Beckham GT, Amore A, Taylor LE, Vander Wall TA, Lunin VV, Zheng F, Garrido M, Schuster L, Fulk EM, Farmer S, Himmel ME, Decker SR. Engineering of glycoside hydrolase family 7 cellobiohydrolases directed by natural diversity screening. J Biol Chem. 2024 03; 300(3):105749.
-
Baljinnyam T, Conrad JW, Sowers ML, Chang-Gu B, Herring JL, Hackfeld LC, Zhang K, Sowers LC. Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing. Chem Res Toxicol. 2023 02 20; 36(2):162-176.
-
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 01; 613(7945):759-766.
-
Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 10 21; 11(10):3318-3329.
-
Copley SD, Newton MS, Widney KA. How to Recruit a Promiscuous Enzyme to Serve a New Function. Biochemistry. 2023 01 17; 62(2):300-308.
-
Hsu CW, Sowers ML, Baljinnyam T, Herring JL, Hackfeld LC, Tang H, Zhang K, Sowers LC. Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase. J Biol Chem. 2022 03; 298(3):101638.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|