 Extracellular Matrix
"Extracellular Matrix" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
| Descriptor ID |
D005109
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| MeSH Number(s) |
A11.284.295.310
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| Concept/Terms |
Extracellular Matrix- Extracellular Matrix
- Matrix, Extracellular
- Extracellular Matrices
- Matrices, Extracellular
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Below are MeSH descriptors whose meaning is more general than "Extracellular Matrix".
Below are MeSH descriptors whose meaning is more specific than "Extracellular Matrix".
This graph shows the total number of publications written about "Extracellular Matrix" by people in this website by year, and whether "Extracellular Matrix" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 | | 1996 | 1 | 0 | 1 | | 1997 | 3 | 1 | 4 | | 2000 | 1 | 2 | 3 | | 2001 | 1 | 2 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 3 | 5 | 8 | | 2004 | 2 | 7 | 9 | | 2005 | 3 | 6 | 9 | | 2006 | 5 | 4 | 9 | | 2007 | 3 | 2 | 5 | | 2008 | 5 | 7 | 12 | | 2009 | 10 | 8 | 18 | | 2010 | 3 | 5 | 8 | | 2011 | 4 | 10 | 14 | | 2012 | 8 | 6 | 14 | | 2013 | 4 | 9 | 13 | | 2014 | 8 | 11 | 19 | | 2015 | 8 | 6 | 14 | | 2016 | 12 | 11 | 23 | | 2017 | 8 | 10 | 18 | | 2018 | 11 | 8 | 19 | | 2019 | 10 | 9 | 19 | | 2020 | 6 | 14 | 20 | | 2021 | 8 | 10 | 18 | | 2022 | 2 | 15 | 17 | | 2023 | 1 | 11 | 12 | | 2024 | 5 | 12 | 17 | | 2025 | 5 | 9 | 14 |
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Below are the most recent publications written about "Extracellular Matrix" by people in Profiles.
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Nishida-Aoki N, Zhu S, Chan M, Kang Y, Fujita M, Jiang X, McCabe M, Vaz JM, Davidson NE, Ghajar CM, Hansen K, Welm AL, Pillarisetty VG, Gujral TS. Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts. Cell Rep Med. 2025 Oct 21; 6(10):102357.
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Barrett A, Maslanka MD, Darula Z, McCabe MC, Saviola AJ, Schmitt LR, Weaver V, Pitts TM, Messersmith WA, Hansen KC. Pancreatic Cancer Progression Involves Increased Lysyl Oxidase-Mediated Collagen Cross-Links as Part of the Desmoplastic Reaction. Biochemistry. 2025 Aug 19; 64(16):3515-3525.
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Zelus EI, Grime J, Saviola A, McCabe M, Hansen KC, Alperin M, Christman KL. Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause. Adv Mater. 2025 Oct; 37(39):e2419977.
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Wagner DE, Alsafadi HN, Mitash N, Justet A, Hu Q, Pineda R, Staab-Weijnitz C, Korfei M, Gvazava N, Wannemo K, Onwuka U, Mozurak M, Estrada-Bernal A, Cala-Garcia J, Mutze K, Costa R, Bölükbas D, Stegmayr J, Skronska-Wasek W, Klee S, Ota C, Baarsma HA, Wang J, Sembrat J, Hilgendorff A, Ding J, Günther A, Chambers R, Rosas I, de Langhe S, Kaminski N, Lehmann M, Eickelberg O, Königshoff M. Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. Nat Commun. 2025 Aug 02; 16(1):7099.
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Rahman MM, Watton PN, Neu CP, Pierce DM. Predicting the heterogeneous chemo-mechano-biological degeneration of cartilage using 3-D biphasic finite elements. Comput Methods Programs Biomed. 2025 Oct; 270:108902.
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McCabe MC, Okamura DM, Erickson CB, Perry BW, Brewer CM, Nguyen ED, Saviola AJ, Majesky MW, Hansen KC. ECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys cahirinus. J Proteome Res. 2025 Jul 04; 24(7):3202-3220.
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Hasenauer A, Bevc K, McCabe MC, Chansoria P, Saviola AJ, Hansen KC, Christman KL, Zenobi-Wong M. Volumetric printed biomimetic scaffolds support in vitro lactation of human milk-derived mammary epithelial cells. Sci Adv. 2025 Jun 06; 11(23):eadu5793.
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Wang C, Fan M, Heo SC, Adams SM, Li T, Liu Y, Li Q, Loebel C, Burdick JA, Lu XL, Birk DE, Alisafaei F, Mauck RL, Han L. Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen. Adv Sci (Weinh). 2025 Aug; 12(32):e14750.
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Abbaspour A, Martinez Cavazos AL, Patel R, Yang N, McGregor SM, Brooks EG, Masters KS, Kreeger PK. Collagen fiber density observed in metastatic ovarian cancer promotes tumor cell adhesion. Acta Biomater. 2025 Jun 15; 200:299-312.
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Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES. Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia. Am J Physiol Lung Cell Mol Physiol. 2025 Jun 01; 328(6):L885-L900.
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