 Interferons
"Interferons" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
| Descriptor ID |
D007372
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| MeSH Number(s) |
D12.644.276.374.440 D12.776.467.374.440 D23.529.374.440
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Interferons".
Below are MeSH descriptors whose meaning is more specific than "Interferons".
This graph shows the total number of publications written about "Interferons" by people in this website by year, and whether "Interferons" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2004 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 1 | 2 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 4 | 4 | | 2014 | 1 | 2 | 3 | | 2015 | 2 | 2 | 4 | | 2016 | 2 | 2 | 4 | | 2017 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 3 | 2 | 5 | | 2020 | 2 | 7 | 9 | | 2021 | 3 | 2 | 5 | | 2022 | 3 | 3 | 6 | | 2023 | 2 | 6 | 8 | | 2024 | 1 | 5 | 6 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interferons" by people in Profiles.
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Souto EP, Gong P, Landua JD, Rajaram Srinivasan R, Ganesan A, Dobrolecki LE, Purdy SC, Pan X, Zeosky M, Chung A, Yi SS, Ford HL, Lewis MT. Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor-Initiating Cells Characterized by IFN/STAT1 Activity. Cancer Res. 2025 Apr 15; 85(8):1390-1409.
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Cozzolino KA, Sanford L, Hunter S, Molison K, Erickson B, Courvan MCS, Jones T, Ajit D, Galbraith MD, Espinosa JM, Bentley D, Allen MA, Dowell RD, Taatjes DJ. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome. Elife. 2025 Feb 10; 13.
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Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen LL, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. Cell. 2024 Dec 26; 187(26):7621-7636.e19.
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Tilden SG, Ricco MH, Hemann EA, Anchordoquy TJ. Exploiting a type III interferon response to improve chemotherapeutic safety and efficacy. Eur J Pharm Sci. 2025 Jan 01; 204:106974.
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Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, Lee C, Tandon R, Rendek A, Aschenbrenner D, Jainarayanan A, Voda A, Siu JHY, Sanches-Peres R, Nee E, Sathananthan D, Kotliar D, Todd P, Kiourlappou M, Gartner L, Ilott N, Issa F, Hester J, Turner J, Nayar S, Mackerodt J, Zhang F, Jonsson A, Brenner M, Raychaudhuri S, Kulicke R, Ramsdell D, Stransky N, Pagliarini R, Bielecki P, Spies N, Marsden B, Taylor S, Wagner A, Klenerman P, Walsh A, Coles M, Jostins-Dean L, Powrie FM, Filer A, Travis S, Uhlig HH, Dendrou CA, Buckley CD. A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease. Nat Immunol. 2024 Nov; 25(11):2152-2165.
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Purdy SC, Ford HL. Remembering Hypoxia: Uncovering the Long-Term Effects of Transient Oxygen Deprivation on IFN Signaling and Progression of Breast Cancer. Cancer Res. 2024 Oct 01; 84(19):3125-3127.
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Luo Y, Su B, Hung V, Luo Y, Shi Y, Wang G, de Graaf D, Dinarello CA, Spaner DE. IL-1 receptor antagonism reveals a yin-yang relationship between NF?B and interferon signaling in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2024 Aug 13; 121(33):e2405644121.
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Colvin KL, Wolter-Warmerdam K, Hickey F, Yeager ME. Altered peripheral blood leukocyte subpopulations, function, and gene expression in children with Down syndrome: implications for respiratory tract infection. Eur J Med Genet. 2024 Apr; 68:104922.
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Ramirez D, B Chuong E, D Dowell R. Nascent transcription upon interferon-a2 stimulation on human and rhesus macaque lymphoblastoid cell lines. BMC Res Notes. 2023 Oct 26; 16(1):292.
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Galbraith MD, Rachubinski AL, Smith KP, Araya P, Waugh KA, Enriquez-Estrada B, Worek K, Granrath RE, Kinning KT, Paul Eduthan N, Ludwig MP, Hsieh EWY, Sullivan KD, Espinosa JM. Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition. Sci Adv. 2023 06 28; 9(26):eadg6218.
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