 Tumor Suppressor Protein p53
"Tumor Suppressor Protein p53" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
| Descriptor ID |
D016159
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| MeSH Number(s) |
D12.776.157.687.650 D12.776.260.820 D12.776.624.776.775 D12.776.660.720.650 D12.776.744.845
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| Concept/Terms |
Tumor Suppressor Protein p53- Tumor Suppressor Protein p53
- p53 Antigen
- TP53 Protein
- TRP53 Protein
- p53 Tumor Suppressor Protein
- pp53 Phosphoprotein
- Phosphoprotein, pp53
- Cellular Tumor Antigen p53
- Oncoprotein p53
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Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p53".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p53".
This graph shows the total number of publications written about "Tumor Suppressor Protein p53" by people in this website by year, and whether "Tumor Suppressor Protein p53" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1996 | 2 | 2 | 4 | | 1997 | 4 | 0 | 4 | | 1998 | 3 | 2 | 5 | | 1999 | 2 | 1 | 3 | | 2000 | 2 | 2 | 4 | | 2001 | 2 | 3 | 5 | | 2002 | 1 | 7 | 8 | | 2003 | 1 | 5 | 6 | | 2004 | 4 | 3 | 7 | | 2005 | 2 | 8 | 10 | | 2006 | 8 | 4 | 12 | | 2007 | 7 | 4 | 11 | | 2008 | 4 | 6 | 10 | | 2009 | 4 | 4 | 8 | | 2010 | 12 | 5 | 17 | | 2011 | 11 | 5 | 16 | | 2012 | 14 | 7 | 21 | | 2013 | 11 | 5 | 16 | | 2014 | 5 | 9 | 14 | | 2015 | 12 | 7 | 19 | | 2016 | 11 | 10 | 21 | | 2017 | 13 | 10 | 23 | | 2018 | 7 | 1 | 8 | | 2019 | 7 | 7 | 14 | | 2020 | 10 | 3 | 13 | | 2021 | 6 | 7 | 13 | | 2022 | 6 | 8 | 14 | | 2023 | 4 | 5 | 9 | | 2024 | 7 | 2 | 9 | | 2025 | 7 | 3 | 10 | | 2026 | 2 | 0 | 2 |
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Below are the most recent publications written about "Tumor Suppressor Protein p53" by people in Profiles.
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Shao C, Indeglia A, Foster M, Casey K, Leung J, Modarai SR, Leu JI, Duong B, Mes-Masson AM, Sims-Mourtada J, Auslander N, Drapkin R, Bitler BG, Zhang N, Murphy ME. Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer. Genes Dev. 2026 Feb 02; 40(3-4):199-214.
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Yasin I, Stengel A, Shao H, Kaur A, Mason EF, Patwardhan PP, Bailey NG, Ghosh S, Inamdar KV, Patel AA, Pandiri M, Zhang J, Sojitra P, Tariq H, Pan Z, Wiredja D, Wang P, Tjota MY, Segal JP, Chang H, Sallman DA, Arber DA, Tefferi A, Badar T, Perry AM, Haferlach C, Lager AM, Venkataraman G. Characterization of chromosome 5 aberrations in TP53 mutated myeloid neoplasms with =5% blasts: An International TP53 Investigators Network (iTiN) study. Cancer. 2026 Jan 01; 132(1):e70210.
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Sharma S, Ali R, Bouska A, Jochum D, Kesireddy M, Mahov S, Lownik J, Zhang W, Lone W, Soma MA, Gamboa A, Devarakonda V, El-Gamal D, Fariha A, Mansoor A, Stewart D, Martin P, Link BK, Advani RH, Barr PM, Goy AH, Mehta A, Kamdar M, Stephens DM, Bachanova V, Smith L, Morin R, Pararajalingam P, Lunning MA, Fu K, Weisenburger D, Chan WC, Khoury J, Greiner TC, Vose JM, Merchant A, Bi C, Iqbal J. Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma. Nat Commun. 2025 Nov 05; 16(1):9762.
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Chakraborty A, Giraldo-Arias J, Merl-Pham J, Dick E, Mastalerz M, Zöller M, Marchi H, Le Gleut R, Hatz RA, Behr J, Hilgendorff A, Hauck SM, Staab-Weijnitz CA. Cholesterol Regulates Airway Epithelial Cell Differentiation by Inhibiting p53 Nuclear Translocation. Int J Mol Sci. 2025 Aug 27; 26(17).
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Pandiri M, Stengel A, Zhang J, Wang P, Shao H, Velmurugan S, Jacob A, Symes E, Kaur A, Rojek A, Sojitra P, Wiredja D, Zhou Q, Chang H, Patil E, Patel JL, Patel AB, Menon M, Ghosh S, Wool GD, Arber DA, Pan Z, Findley A, Badar T, Tariq H, Sallman D, Bell RC, Perry A, Haferlach C, Fitzpatrick C, Venkataraman G. Karyotypic clonal fraction predicts adverse outcome in TP53-mutated myeloid neoplasms: an International TP53 investigators Network (iTiN) study. J Clin Pathol. 2025 Aug 18; 78(9):629-635.
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McGivney GR, Brockman QR, Borcherding N, Scherer A, Rauckhorst AJ, Gutierrez WR, Solst SR, Heer CD, Warrier A, Floyd W, Kirsch DG, Knepper-Adrian VL, Laverty EA, Roughton GA, Spitz DR, Taylor EB, Dodd RD. Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Sci Adv. 2025 Aug 15; 11(33):eadu2906.
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Nguyen KA, McLemore LE, Ke Y, DePledge LN, Smith LP, Bian L, Aleman JD, Debretsion D, Wong E, Manning N, Wang XJ, Young CD. Activation of PI3K and deletion of p53 in keratin 15-expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer. J Pathol. 2025 Oct; 267(2):213-224.
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Chattopadhyay M, Jenkins EC, Janssen W, Mashaka T, Germain D. Differential ER stress responses during lactation and postpartum outcomes in mice depending on their mitochondrial genotype. Nat Commun. 2025 Jul 11; 16(1):6432.
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Skuli SJ, Bakayoko A, Kruidenier M, Manning B, Pammer P, Salimov A, Riley O, Brake-Sillá G, Dopkin D, Bowman M, Martinez-Gutierrez LN, Anderson CC, Reisz JA, Buono R, Paul M, Saland E, Liccardo F, DeVine A, Wong S, Xu JP, Nee E, Hausler R, Boettcher S, Sebti SM, Lai C, Maxwell KN, Sarry JE, Fruman DA, D'Alessandro A, Mesaros C, Keith B, Simon MC, Sung PJ, Wertheim G, Skuli N, Bowman RL, Matthews A, Carroll M. Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response. Leukemia. 2025 Sep; 39(9):2087-2098.
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Cotton K, Comer C, Caporali S, Butera A, Gurres S, Capradossi F, D'Alessandro A, Amelio I, Niklison-Chirou MV. Lipidome atlas of p53 mutant variants in pancreatic cancer. Biol Direct. 2025 Apr 11; 20(1):51.
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