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Maria Cecilia Caino

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Biography 
    Collapse education and training
    Universidad Nacional de Mar del Plata, ArgentinaMS2004Biology
    Universidad de Buenos Aires, ArgentinaPhD2010Cancer Cell Biology
    University of Pennsylvania, Philadelphia, PAvisiting student & postdoc2011Cancer Biology
    The Wistar Institute, Philadelphia, PApostdoctoral2017Tumor Microenvironment & Metastasis

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R35GM142774     (CAINO, MARIA CECILIA)Jun 15, 2021 - Apr 30, 2026
    NIH
    Regulation of mitochondrial dynamics pathways in mammalian cells
    Role: Principal Investigator
    Webb-Waring Biomedical Research Award     (Caino)Jul 1, 2019 - Jun 30, 2022
    Boettcher Foundation
    A novel mitochondrial signaling pathway regulates tumor cell metastasis
    Role: Principal Investigator
    ACS IRG##16-184-56     (Richer)Jan 1, 2018 - Dec 31, 2018
    American Cancer Society
    Role of mitochondrial Rho GTPases (MIROs) in prostate cancer invasion
    Role Description: Institutional Research Grant
    Role: PI
    Challenge Award     (Altieri)Jul 1, 2015 - Jun 30, 2017
    Prostate Cancer Foundation
    Metabolic Reprogramming in Prostate Cancer Therapy
    Role: co-PI and Young Investigator
    F32CA177018     (CAINO, MARIA CECILIA)Sep 23, 2013 - Sep 22, 2016
    NIH
    Mitochondrial Hsp90s Regulation of Tumor Bioenergetics and Metastasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ohm AM, Affandi T, Reisz JA, Caino MC, D'Alessandro A, Reyland ME. Metabolic reprogramming contributes to radioprotection by protein kinase Cd. J Biol Chem. 2023 Oct; 299(10):105186. PMID: 37611829.
      View in: PubMed
    2. Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. J Biol Chem. 2023 06; 299(6):104774. PMID: 37142218.
      View in: PubMed
    3. O'Neill KI, Kuo LW, Williams MM, Lind H, Crump LS, Hammond NG, Spoelstra NS, Caino MC, Richer JK. NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer. Cancers (Basel). 2022 Jul 21; 14(14). PMID: 35884604.
      View in: PubMed
    4. Furnish M, Boulton DP, Genther V, Grofova D, Ellinwood ML, Romero L, Lucia MS, Cramer SD, Caino MC. MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. Mol Cancer Res. 2022 04 01; 20(4):607-621. PMID: 34992146.
      View in: PubMed
    5. Boulton DP, Caino MC. Mitochondrial Fission and Fusion in Tumor Progression to Metastasis. Front Cell Dev Biol. 2022; 10:849962. PMID: 35356277.
      View in: PubMed
    6. Ghosh JC, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman AR, Tang HY, Kossenkov AV, Landis CJ, Languino LR, Plow EF, Morotti A, Ottobrini L, Locatelli M, Speicher DW, Caino MC, Cassel J, Salvino JM, Robert ME, Vaira V, Altieri DC. Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). PMID: 35177476.
      View in: PubMed
    7. Towers CG, Wodetzki DK, Thorburn J, Smith KR, Caino MC, Thorburn A. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy. Dev Cell. 2021 07 26; 56(14):2029-2042.e5. PMID: 34171288.
      View in: PubMed
    8. Li J, Agarwal E, Bertolini I, Seo JH, Caino MC, Ghosh JC, Kossenkov AV, Liu Q, Tang HY, Goldman AR, Languino LR, Speicher DW, Altieri DC. The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells. Sci Signal. 2020 07 28; 13(642). PMID: 32723812.
      View in: PubMed
    9. Alicea GM, Rebecca VW, Goldman AR, Fane ME, Douglass SM, Behera R, Webster MR, Kugel CH, Ecker BL, Caino MC, Kossenkov AV, Tang HY, Frederick DT, Flaherty KT, Xu X, Liu Q, Gabrilovich DI, Herlyn M, Blair IA, Schug ZT, Speicher DW, Weeraratna AT. Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2. Cancer Discov. 2020 09; 10(9):1282-1295. PMID: 32499221.
      View in: PubMed
    10. Lee YG, Nam Y, Shin KJ, Yoon S, Park WS, Joung JY, Seo JK, Jang J, Lee S, Nam D, Caino MC, Suh PG, Chan Chae Y. Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer. Cancer Lett. 2020 02 28; 471:72-87. PMID: 31838085.
      View in: PubMed
    11. Wheeler LJ, Watson ZL, Qamar L, Yamamoto TM, Sawyer BT, Sullivan KD, Khanal S, Joshi M, Ferchaud-Roucher V, Smith H, Vanderlinden LA, Brubaker SW, Caino CM, Kim H, Espinosa JM, Richer JK, Bitler BG. Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. iScience. 2019 Sep 27; 19:474-491. PMID: 31437751.
      View in: PubMed
    12. Furnish M, Caino MC. Altered mitochondrial trafficking as a novel mechanism of cancer metastasis. Cancer Rep (Hoboken). 2020 02; 3(1):e1157. PMID: 32671955.
      View in: PubMed
    13. Furnish M, Caino MC. Altered mitochondrial trafficking as a novel mechanism of cancer metastasis. Cancer Reports. 2019; (In Press):e1157.
      View Publication
    14. Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC. Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. Cancer Res. 2018 08 01; 78(15):4215-4228. PMID: 29898993.
      View in: PubMed
    15. Williams M, Caino MC. Mitochondrial Dynamics in Type 2 Diabetes and Cancer. Front Endocrinol (Lausanne). 2018; 9:211. PMID: 29755415.
      View in: PubMed
    16. Caino MC, Seo JH, Wang Y, Rivadeneira DB, Gabrilovich DI, Kim ET, Weeraratna AT, Languino LR, Altieri DC. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017 Oct 02; 127(10):3755-3769. PMID: 28891816.
      View in: PubMed
    17. Behera R, Kaur A, Webster MR, Kim S, Ndoye A, Kugel CH, Alicea GM, Wang J, Ghosh K, Cheng P, Lisanti S, Marchbank K, Dang V, Levesque M, Dummer R, Xu X, Herlyn M, Aplin AE, Roesch A, Caino C, Altieri DC, Weeraratna AT. Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017 Jun 15; 23(12):3181-3190. PMID: 28232477.
      View in: PubMed
    18. Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC. A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun. 2016 12 19; 7:13730. PMID: 27991488.
      View in: PubMed
    19. Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC. Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell. 2016 08 08; 30(2):257-272. PMID: 27505672.
      View in: PubMed
    20. Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol. 2016 07; 14(7):e1002507. PMID: 27389535.
      View in: PubMed
    21. Caino MC, Altieri DC. Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy. Clin Cancer Res. 2016 Feb 01; 22(3):540-5. PMID: 26660517.
      View in: PubMed
    22. Caino MC, Altieri DC. Disabling mitochondrial reprogramming in cancer. Pharmacol Res. 2015 Dec; 102:42-5. PMID: 26365877.
      View in: PubMed
    23. Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal. 2015 Aug 11; 8(389):ra80. PMID: 26268608.
      View in: PubMed
    24. Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8638-43. PMID: 26124089.
      View in: PubMed
    25. Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC. Adaptive mitochondrial reprogramming and resistance to PI3K therapy. J Natl Cancer Inst. 2015 Mar; 107(3). PMID: 25650317.
      View in: PubMed
    26. Caino MC, Altieri DC. Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion. Cell Cycle. 2015; 14(20):3242-7. PMID: 26317663.
      View in: PubMed
    27. Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. PLoS One. 2013; 8(6):e67319. PMID: 23826267.
      View in: PubMed
    28. Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J Clin Invest. 2013 Jul; 123(7):2907-20. PMID: 23921130.
      View in: PubMed
    29. Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC. Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell. 2012 Sep 11; 22(3):331-44. PMID: 22975376.
      View in: PubMed
    30. Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One. 2012; 7(2):e31714. PMID: 22384062.
      View in: PubMed
    31. Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase C? is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene. 2012 May 17; 31(20):2593-600. PMID: 21996750.
      View in: PubMed
    32. Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem. 2011 Apr 01; 286(13):11254-64. PMID: 21252239.
      View in: PubMed
    33. Filone CM, Hanna SL, Caino MC, Bambina S, Doms RW, Cherry S. Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. PLoS One. 2010 Nov 24; 5(11):e15483. PMID: 21124804.
      View in: PubMed
    34. Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem. 2010 Aug 20; 285(34):26033-40. PMID: 20566643.
      View in: PubMed
    35. Griner EM, Caino MC, Sosa MS, Col?n-Gonz?lez F, Chalmers MJ, Mischak H, Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010 May 28; 285(22):16931-41. PMID: 20335173.
      View in: PubMed
    36. Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis. 2009 Apr; 14(4):392-408. PMID: 19169823.
      View in: PubMed
    37. Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods Enzymol. 2008; 446:123-39. PMID: 18603119.
      View in: PubMed
    38. Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG. S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem. 2008 Feb 29; 283(9):5466-76. PMID: 18162471.
      View in: PubMed
    39. Caino MC, Oliva JL, Jiang H, Penning TM, Kazanietz MG. Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol. 2007 Mar; 71(3):744-50. PMID: 17114299.
      View in: PubMed
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