 Histones
"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
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| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 2 | 6 | 8 | | 2002 | 1 | 2 | 3 | | 2003 | 5 | 0 | 5 | | 2004 | 5 | 2 | 7 | | 2005 | 6 | 2 | 8 | | 2006 | 9 | 6 | 15 | | 2007 | 4 | 5 | 9 | | 2008 | 7 | 6 | 13 | | 2009 | 11 | 4 | 15 | | 2010 | 5 | 9 | 14 | | 2011 | 11 | 10 | 21 | | 2012 | 16 | 11 | 27 | | 2013 | 10 | 13 | 23 | | 2014 | 8 | 14 | 22 | | 2015 | 4 | 17 | 21 | | 2016 | 17 | 13 | 30 | | 2017 | 20 | 6 | 26 | | 2018 | 18 | 11 | 29 | | 2019 | 14 | 13 | 27 | | 2020 | 11 | 20 | 31 | | 2021 | 15 | 12 | 27 | | 2022 | 11 | 9 | 20 | | 2023 | 14 | 10 | 24 | | 2024 | 14 | 5 | 19 | | 2025 | 7 | 3 | 10 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Villalta A, Bisio H, Toner CM, Abergel C, Luger K. Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures. Nat Commun. 2025 Jul 26; 16(1):6903.
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Becht DC, Biswas S, Xu C, Xuan H, Khalil M, Cai L, Musselman CA, Liu X, Affar EB, Shi X, Wang GG, Kutateladze TG. Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300. Biochem J. 2025 Jul 02; 482(13):955-968.
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Ugolini A, De Leo A, Yu X, Scirocchi F, Liu X, Peixoto B, Scocozza D, Pace A, Perego M, Gardini A, D'Angelo L, Liu JKC, Etame AB, Rughetti A, Nuti M, Santoro A, Vogelbaum MA, Conejo-Garcia JR, Rodriguez PC, Veglia F. Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation. Cancer Discov. 2025 Jun 03; 15(6):1270-1296.
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Becht DC, Song J, Selvam K, Yin K, Bai W, Zhao Y, Wu R, Zheng YG, Kutateladze TG. The YEATS domain is a selective reader of histone methacrylation. Structure. 2025 Jul 03; 33(7):1233-1239.e5.
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Trouth A, Ravichandran K, Gafken PR, Martire S, Boyle GE, Veronezi GMB, La V, Namciu SJ, Banaszynski LA, Sarthy JF, Ramachandran S. The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types. PLoS Biol. 2025 Apr; 23(4):e3003119.
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Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Egan G, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM. Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs. Nature. 2025 Jun; 642(8067):421-430.
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Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, C?t? J, Shi X, Zhou MM, Kutateladze TG. Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Nat Commun. 2025 Mar 06; 16(1):2235.
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Brown MT, McMurray MA. Stepwise order in protein complex assembly: approaches and emerging themes. Open Biol. 2025 Jan; 15(1):240283.
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Pashos ARS, Meyer AR, Bussey-Sutton C, O'Connor ES, Coradin M, Coulombe M, Riemondy KA, Potlapelly S, Strahl BD, Hansson GC, Dempsey PJ, Brumbaugh J. H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium. Nat Cell Biol. 2025 Feb; 27(2):202-217.
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Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E. Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat Struct Mol Biol. 2025 Feb; 32(2):393-404.
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