 Histones
"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
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| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 2 | 2 | 4 | | 2002 | 0 | 1 | 1 | | 2003 | 5 | 0 | 5 | | 2004 | 5 | 2 | 7 | | 2005 | 7 | 1 | 8 | | 2006 | 8 | 6 | 14 | | 2007 | 4 | 4 | 8 | | 2008 | 6 | 6 | 12 | | 2009 | 9 | 5 | 14 | | 2010 | 5 | 9 | 14 | | 2011 | 9 | 10 | 19 | | 2012 | 15 | 10 | 25 | | 2013 | 9 | 11 | 20 | | 2014 | 8 | 13 | 21 | | 2015 | 3 | 12 | 15 | | 2016 | 15 | 12 | 27 | | 2017 | 19 | 6 | 25 | | 2018 | 16 | 9 | 25 | | 2019 | 13 | 12 | 25 | | 2020 | 9 | 18 | 27 | | 2021 | 12 | 11 | 23 | | 2022 | 8 | 7 | 15 | | 2023 | 12 | 7 | 19 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Chatzikyriakou P, Brempou D, Quinn M, Fishbein L, Noberini R, Anastopoulos IN, Tufton N, Lim ES, Obholzer R, Hubbard JG, Moonim M, Bonaldi T, Nathanson KL, Izatt L, Oakey RJ. A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide. Clin Epigenetics. 2023 12 20; 15(1):196.
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Scadden AW, Graybill AS, Hull-Crew C, Lundberg TJ, Lande NM, Klocko AD. Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of Neurospora crassa. Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47):e2311249120.
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Serdyukova K, Swearingen AR, Coradin M, Nevo M, Tran H, Bajric E, Brumbaugh J. Leveraging dominant-negative histone H3 K-to-M mutations to study chromatin during differentiation and development. Development. 2023 11 01; 150(21).
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Kellett T, Noor R, Zhou Q, Esquer H, Sala R, Stojanovic P, Rudolph J, Luger K, LaBarbera DV. HTS discovery of PARP1-HPF1 complex inhibitors in cancer. SLAS Discov. 2023 12; 28(8):394-401.
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Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337.
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Holay N, Somma A, Duchow M, Soleimani M, Capasso A, Kottapalli S, Rios J, Giri U, Diamond J, Schreiber A, Piscopio AD, Van Den Berg C, Eckhardt SG, Triplett TA. Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy. Front Immunol. 2023; 14:1260545.
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Maldonado L?pez AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC. Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Sci Adv. 2023 09; 9(35):eadg5234.
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Ravindran Menon D, Hammerlindl H, Gimenez G, Hammerlindl S, Zuegner E, Torrano J, Bordag N, Emran AA, Giam M, Denil S, Pavelka N, Tan AC, Sturm RA, Haass NK, Rancati G, Herlyn M, Magnes C, Eccles MR, Fujita M, Schaider H. H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase. Drug Resist Updat. 2023 Nov; 71:100993.
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Stojanovic P, Luger K, Rudolph J. Slow Dissociation from the PARP1-HPF1 Complex Drives Inhibitor Potency. Biochemistry. 2023 08 15; 62(16):2382-2390.
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Bitler BG, Bailey CA, Yamamoto TM, McMellen A, Kim H, Watson ZL. Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma. Mol Carcinog. 2023 11; 62(11):1717-1730.
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