 Eukaryotic Initiation Factor-2
"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
| Descriptor ID |
D015852
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| MeSH Number(s) |
D12.776.835.725.868.249
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| Concept/Terms |
Eukaryotic Initiation Factor-2- Eukaryotic Initiation Factor-2
- Eukaryotic Initiation Factor 2
- Initiation Factor-2, Eukaryotic
- Peptide Initiation Factor EIF-2
- Peptide Initiation Factor EIF 2
- Eukaryotic Peptide Initiation Factor-2
- Eukaryotic Peptide Initiation Factor 2
- EIF-2
- EIF 2
- EIF2
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Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in this website by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.
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Blumhagen RZ, Kurche JS, Cool CD, Walts AD, Heinz D, Fingerlin TE, Yang IV, Schwartz DA. Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis. Respir Res. 2023 Nov 17; 24(1):287.
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Andrysik Z, Sullivan KD, Kieft JS, Espinosa JM. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nat Commun. 2022 12 01; 13(1):7400.
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Llerena Cari E, Hagen-Lillevik S, Giornazi A, Post M, Komar AA, Appiah L, Bitler B, Polotsky AJ, Santoro N, Kieft J, Lai K, Johnson J. Integrated stress response control of granulosa cell translation and proliferation during normal ovarian follicle development. Mol Hum Reprod. 2021 08 07; 27(8).
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Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O'Malley BW, Beirowski B, Poitelon Y, Wrabetz L, Feltri ML. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021 06 02; 12(1):3285.
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Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks MM, Parker R, Goodfellow IG, Ruggieri A, Locker N. Norovirus infection results in eIF2a independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation. PLoS Pathog. 2020 01; 16(1):e1008250.
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Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai K. Salubrinal enhances eIF2a phosphorylation and improves fertility in a mouse model of Classic Galactosemia. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165516.
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Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. PLoS Pathog. 2019 06; 15(6):e1007746.
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Tauber D, Parker R. 15-Deoxy-?12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2a and activates the integrated stress response. J Biol Chem. 2019 04 19; 294(16):6344-6352.
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Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439).
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Moon SL, Sonenberg N, Parker R. Neuronal Regulation of eIF2a Function in Health and Neurological Disorders. Trends Mol Med. 2018 06; 24(6):575-589.
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