 Eukaryotic Initiation Factor-2
"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
| Descriptor ID |
D015852
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| MeSH Number(s) |
D12.776.835.725.868.249
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| Concept/Terms |
Eukaryotic Initiation Factor-2- Eukaryotic Initiation Factor-2
- Eukaryotic Initiation Factor 2
- Initiation Factor-2, Eukaryotic
- Peptide Initiation Factor EIF-2
- Peptide Initiation Factor EIF 2
- Eukaryotic Peptide Initiation Factor-2
- Eukaryotic Peptide Initiation Factor 2
- EIF-2
- EIF 2
- EIF2
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Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in this website by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.
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Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A. Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease. JCI Insight. 2024 Sep 05; 9(19).
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Puig-Segui MS, Decker CJ, Barlit H, Labunskyy VM, Parker R, Puig S. Regulation of translation in response to iron deficiency in human cells. Sci Rep. 2024 04 11; 14(1):8451.
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Blumhagen RZ, Kurche JS, Cool CD, Walts AD, Heinz D, Fingerlin TE, Yang IV, Schwartz DA. Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis. Respir Res. 2023 Nov 17; 24(1):287.
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Andrysik Z, Sullivan KD, Kieft JS, Espinosa JM. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nat Commun. 2022 12 01; 13(1):7400.
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Kidwell A, Yadav SPS, Maier B, Zollman A, Ni K, Halim A, Janosevic D, Myslinski J, Syed F, Zeng L, Waffo AB, Banno K, Xuei X, Doud EH, Dagher PC, Hato T. Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model. J Am Soc Nephrol. 2023 02 01; 34(2):220-240.
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Llerena Cari E, Hagen-Lillevik S, Giornazi A, Post M, Komar AA, Appiah L, Bitler B, Polotsky AJ, Santoro N, Kieft J, Lai K, Johnson J. Integrated stress response control of granulosa cell translation and proliferation during normal ovarian follicle development. Mol Hum Reprod. 2021 08 07; 27(8).
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Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O'Malley BW, Beirowski B, Poitelon Y, Wrabetz L, Feltri ML. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021 06 02; 12(1):3285.
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Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks MM, Parker R, Goodfellow IG, Ruggieri A, Locker N. Norovirus infection results in eIF2a independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation. PLoS Pathog. 2020 01; 16(1):e1008250.
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Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai K. Salubrinal enhances eIF2a phosphorylation and improves fertility in a mouse model of Classic Galactosemia. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165516.
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Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. PLoS Pathog. 2019 06; 15(6):e1007746.
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