 T-Lymphocytes, Regulatory
"T-Lymphocytes, Regulatory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
| Descriptor ID |
D050378
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| MeSH Number(s) |
A11.118.637.555.567.550.500.700 A11.118.637.555.567.569.200.700 A11.118.637.555.567.569.500.700 A15.145.229.637.555.567.550.500.700 A15.145.229.637.555.567.569.200.700 A15.145.229.637.555.567.569.500.700 A15.382.490.555.567.550.500.700 A15.382.490.555.567.569.200.700 A15.382.490.555.567.569.500.700
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| Concept/Terms |
T-Lymphocytes, Regulatory- T-Lymphocytes, Regulatory
- T Lymphocytes, Regulatory
- Regulatory T-Lymphocytes
- Regulatory T Lymphocytes
- Regulatory T-Lymphocyte
- T-Lymphocyte, Regulatory
- Regulatory T-Cells
- Regulatory T Cells
- T-Cells, Regulatory
- T Cells, Regulatory
- Treg Cells
- Cell, Treg
- Cells, Treg
- Treg Cell
Th3 Cells- Th3 Cells
- Cell, Th3
- Cells, Th3
- Th3 Cell
Suppressor T-Lymphocytes, Naturally-Occurring- Suppressor T-Lymphocytes, Naturally-Occurring
- Naturally-Occurring Suppressor T-Lymphocyte
- Naturally-Occurring Suppressor T-Lymphocytes
- Suppressor T Lymphocytes, Naturally Occurring
- Suppressor T-Lymphocyte, Naturally-Occurring
- Suppressor T-Cells, Naturally-Occurring
- Naturally-Occurring Suppressor T-Cell
- Naturally-Occurring Suppressor T-Cells
- Suppressor T Cells, Naturally Occurring
- Suppressor T-Cell, Naturally-Occurring
- T-Cell, Naturally-Occurring Suppressor
- T-Cells, Naturally-Occurring Suppressor
Tr1 Cells- Tr1 Cells
- Cell, Tr1
- Cells, Tr1
- Tr1 Cell
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Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Regulatory".
- Anatomy [A]
- Cells [A11]
- Blood Cells [A11.118]
- Leukocytes [A11.118.637]
- Leukocytes, Mononuclear [A11.118.637.555]
- Lymphocytes [A11.118.637.555.567]
- Lymphocyte Subsets [A11.118.637.555.567.550]
- T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
- T-Lymphocytes, Regulatory [A11.118.637.555.567.550.500.700]
- T-Lymphocytes [A11.118.637.555.567.569]
- CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
- T-Lymphocytes, Regulatory [A11.118.637.555.567.569.200.700]
- T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
- T-Lymphocytes, Regulatory [A11.118.637.555.567.569.500.700]
- Hemic and Immune Systems [A15]
- Blood [A15.145]
- Blood Cells [A15.145.229]
- Leukocytes [A15.145.229.637]
- Leukocytes, Mononuclear [A15.145.229.637.555]
- Lymphocytes [A15.145.229.637.555.567]
- Lymphocyte Subsets [A15.145.229.637.555.567.550]
- T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
- T-Lymphocytes, Regulatory [A15.145.229.637.555.567.550.500.700]
- T-Lymphocytes [A15.145.229.637.555.567.569]
- CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
- T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.200.700]
- T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
- T-Lymphocytes, Regulatory [A15.145.229.637.555.567.569.500.700]
- Immune System [A15.382]
- Leukocytes [A15.382.490]
- Leukocytes, Mononuclear [A15.382.490.555]
- Lymphocytes [A15.382.490.555.567]
- Lymphocyte Subsets [A15.382.490.555.567.550]
- T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
- T-Lymphocytes, Regulatory [A15.382.490.555.567.550.500.700]
- T-Lymphocytes [A15.382.490.555.567.569]
- CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
- T-Lymphocytes, Regulatory [A15.382.490.555.567.569.200.700]
- T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
- T-Lymphocytes, Regulatory [A15.382.490.555.567.569.500.700]
Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Regulatory".
This graph shows the total number of publications written about "T-Lymphocytes, Regulatory" by people in this website by year, and whether "T-Lymphocytes, Regulatory" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 4 | 0 | 4 | | 2006 | 6 | 1 | 7 | | 2007 | 11 | 1 | 12 | | 2008 | 18 | 4 | 22 | | 2009 | 13 | 3 | 16 | | 2010 | 6 | 2 | 8 | | 2011 | 7 | 5 | 12 | | 2012 | 9 | 2 | 11 | | 2013 | 8 | 5 | 13 | | 2014 | 12 | 8 | 20 | | 2015 | 8 | 2 | 10 | | 2016 | 8 | 6 | 14 | | 2017 | 12 | 2 | 14 | | 2018 | 7 | 1 | 8 | | 2019 | 7 | 8 | 15 | | 2020 | 4 | 1 | 5 | | 2021 | 6 | 5 | 11 | | 2022 | 3 | 9 | 12 | | 2023 | 3 | 6 | 9 | | 2024 | 1 | 4 | 5 | | 2025 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "T-Lymphocytes, Regulatory" by people in Profiles.
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Cabrera-Martinez B, Garcia-Perez JE, Baxter RM, Lui VG, Ghosh T, Eken A, Kostka-Newman Z, Garcia JRM, Rahkola J, Gessner RL, Dutmer CM, Klarquist J, Pietras EM, Ghosh D, Johnson SA, Kedl RM, Hsieh EWY. A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rß deficiency. Cell Rep. 2025 Jul 22; 44(7):115902.
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Teng KWW, Khoo WH, Ho NCW, Yang SJ, Wilson DC, Chua E, Ho SWS. Diving Deep: Profiling Exhausted T Cells in the Tumor Microenvironment Using Spectral Flow Cytometry. Cytometry A. 2025 Apr; 107(4):271-280.
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Johnson MJ, Lazarus SK, Bennett AE, Tovar-Salazar A, Robertson CE, Kofonow JM, Li S, McCollister B, Nunes MC, Madhi SA, Frank DN, Weinberg A. Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants. Front Immunol. 2025; 16:1533003.
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Gonzalez NM, Zou D, Zeng Z, Feng FX, Zhang X, Sannes C, Gu A, Zu Y, Chen W. Transient Anti-TCR? mAb Treatment Induces CD4 + T Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus. Immunology. 2025 02; 174(2):239-246.
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Peeters JGC, Silveria S, Ozdemir M, Ramachandran S, DuPage M. Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation. Cell Rep. 2024 09 24; 43(9):114724.
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Kotwal A, Vance K, Hajric K, Yuil-Valdes A, Swanson B, Martinez Duarte E, Shats O, Hollingsworth M, Band H, Goldner W. Characterization of Immune Infiltrate Along the Leading Edge of Differentiated Thyroid Cancer. Thyroid. 2024 08; 34(8):999-1006.
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Guruprasad P, Carturan A, Zhang Y, Cho JH, Kumashie KG, Patel RP, Kim KH, Lee JS, Lee Y, Kim JH, Chung J, Joshi A, Cohen I, Shestov M, Ghilardi G, Harris J, Pajarillo R, Angelos M, Lee YG, Liu S, Rodriguez J, Wang M, Ballard HJ, Gupta A, Ugwuanyi OH, Hong SJA, Bochi-Layec AC, Sauter CT, Chen L, Paruzzo L, Kammerman S, Shestova O, Liu D, Vella LA, Schuster SJ, Svoboda J, Porazzi P, Ruella M. The BTLA-HVEM axis restricts CAR T cell efficacy in cancer. Nat Immunol. 2024 Jun; 25(6):1020-1032.
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Hosonuma M, Hirasawa Y, Kuramasu A, Murayama M, Narikawa Y, Toyoda H, Baba Y, Isobe J, Funayama E, Tajima K, Shida M, Hamada K, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Ohkuma R, Kubota Y, Horiike A, Sambe T, Tsuji M, Wada S, Kiuchi Y, Kobayashi S, Tsunoda T, Yoshimura K. Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit. Cancer Sci. 2024 Mar; 115(3):752-762.
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Collins CB, Nguyen TT, Leddy RS, Alula KM, Yeckes AR, Strassheim D, Aherne CM, Luck ME, Karoor V, Jedlicka P, Pierce A, de Zoeten EF. Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation. Mucosal Immunol. 2024 Feb; 17(1):94-110.
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Thatte AS, Hamilton AG, Nachod BE, Mukalel AJ, Billingsley MM, Palanki R, Swingle KL, Mitchell MJ. mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies. Nano Lett. 2023 11 22; 23(22):10179-10188.
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