 Nitric Oxide
"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
| Descriptor ID |
D009569
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| MeSH Number(s) |
D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
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| Concept/Terms |
Nitric Oxide- Nitric Oxide
- Oxide, Nitric
- Nitrogen Monoxide
- Monoxide, Nitrogen
- Nitric Oxide, Endothelium-Derived
- Endothelium-Derived Nitric Oxide
- Nitric Oxide, Endothelium Derived
- Endogenous Nitrate Vasodilator
- Nitrate Vasodilator, Endogenous
- Vasodilator, Endogenous Nitrate
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
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Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".
Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".
This graph shows the total number of publications written about "Nitric Oxide" by people in this website by year, and whether "Nitric Oxide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 14 | 6 | 20 | | 1996 | 12 | 1 | 13 | | 1997 | 19 | 7 | 26 | | 1998 | 14 | 5 | 19 | | 1999 | 13 | 7 | 20 | | 2000 | 8 | 2 | 10 | | 2001 | 6 | 7 | 13 | | 2002 | 7 | 13 | 20 | | 2003 | 10 | 4 | 14 | | 2004 | 10 | 8 | 18 | | 2005 | 13 | 14 | 27 | | 2006 | 7 | 7 | 14 | | 2007 | 10 | 15 | 25 | | 2008 | 15 | 15 | 30 | | 2009 | 6 | 13 | 19 | | 2010 | 8 | 12 | 20 | | 2011 | 10 | 11 | 21 | | 2012 | 9 | 12 | 21 | | 2013 | 11 | 10 | 21 | | 2014 | 10 | 13 | 23 | | 2015 | 8 | 10 | 18 | | 2016 | 11 | 8 | 19 | | 2017 | 3 | 5 | 8 | | 2018 | 5 | 9 | 14 | | 2019 | 6 | 14 | 20 | | 2020 | 12 | 12 | 24 | | 2021 | 11 | 9 | 20 | | 2022 | 1 | 14 | 15 | | 2023 | 2 | 11 | 13 | | 2024 | 5 | 5 | 10 | | 2025 | 0 | 5 | 5 |
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Below are the most recent publications written about "Nitric Oxide" by people in Profiles.
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Jeffrey DA, Russell AN, Ferris HR, Romero PZ, Bueno Guerrero M, Fontaine JT, Hashad AM, Bolt MA, Fosdick BK, Rosehart AC, Harraz OF, Dabertrand F. Estrogen Enhances SK Channel Activity to Limit Hippocampal Arteriole Constriction. Circ Res. 2025 Aug; 137(4):456-470.
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Berry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Orozco-Fersiva NC, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function. J Appl Physiol (1985). 2025 Jun 01; 138(6):1571-1577.
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Cho ME, Brunt VE, Shiu YT, Bunsawat K. Endothelial dysfunction in chronic kidney disease: a clinical perspective. Am J Physiol Heart Circ Physiol. 2025 Jul 01; 329(1):H135-H153.
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Duffus EK, Holguin F, Rastogi D. Non-T2 asthma. Curr Opin Pulm Med. 2025 May 01; 31(3):287-293.
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Saternos HC, Forero KV, Meqdad MA, Buqaileh R, Sunderman CL, Gallagher G, Messer WS, Mohieldin AM, Mucci CA, Kumariya S, Osman IA, Burkett JP, AbouAlaiwi WA. Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition. Sci Rep. 2025 01 30; 15(1):3745.
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Garcia VP, Stockelman KA, Levy MV, Fandl HK, Goulding A, Hijmans JG, Ruzzene ST, Berry AR, Greiner JJ, DeSouza CA. Microvesicles Derived from Nitric Oxide Synthase-Inhibited Endothelial Cells Promote Cell Dysfunction. J Vasc Res. 2025; 62(1):10-21.
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Wiens KR, Brooks NAH, Riar I, Greuel BK, Lindhout IA, Klegeris A. Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner. Molecules. 2024 Oct 28; 29(21).
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Gap-Gaupool B, Glenn SM, Milburn E, Turapov O, Crosatti M, Hincks J, Stewart B, Bacon J, Kendall SL, Voskuil MI, Riabova O, Monakhova N, Green J, Waddell SJ, Makarov VA, Mukamolova GV. Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis. Commun Biol. 2024 Sep 28; 7(1):1206.
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Fernando V, Zheng X, Sharma V, Sweef O, Choi ES, Furuta S. Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism. Life Sci Alliance. 2024 11; 7(11).
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Dunaway LS, Cook AK, Kellum CE, Edell C, Botta D, Molina PA, Sedaka RS, d'Uscio LV, Katusic ZS, Pollock DM, Inscho EW, Pollock JS. Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet. Acta Physiol (Oxf). 2024 Sep; 240(9):e14201.
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