 Blood-Brain Barrier
"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
| Descriptor ID |
D001812
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| MeSH Number(s) |
A07.035 A08.186.211.035
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| Concept/Terms |
Blood-Brain Barrier- Blood-Brain Barrier
- Barrier, Blood-Brain
- Barriers, Blood-Brain
- Blood Brain Barrier
- Blood-Brain Barriers
- Hemato-Encephalic Barrier
- Barrier, Hemato-Encephalic
- Barriers, Hemato-Encephalic
- Hemato Encephalic Barrier
- Hemato-Encephalic Barriers
- Brain-Blood Barrier
- Barrier, Brain-Blood
- Barriers, Brain-Blood
- Brain Blood Barrier
- Brain-Blood Barriers
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Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".
Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".
This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 2 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 2 | 3 | 5 | | 2008 | 1 | 4 | 5 | | 2009 | 6 | 3 | 9 | | 2010 | 3 | 4 | 7 | | 2011 | 3 | 3 | 6 | | 2012 | 1 | 3 | 4 | | 2013 | 4 | 2 | 6 | | 2014 | 4 | 1 | 5 | | 2015 | 2 | 0 | 2 | | 2016 | 4 | 4 | 8 | | 2017 | 3 | 3 | 6 | | 2018 | 2 | 2 | 4 | | 2019 | 4 | 3 | 7 | | 2020 | 0 | 2 | 2 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 3 | 4 | | 2023 | 0 | 3 | 3 | | 2024 | 7 | 3 | 10 | | 2025 | 2 | 2 | 4 |
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Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.
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de Castro LL, Gomes da Rosa B, Peixoto-Rodrigues MC, Revoredo Vicentino AR, Fraga-Junior VdS, Cascabulho CM, Diniz LP, Benjamim CF, Bracko O, Scharfstein J, Adesse D. Toxoplasma gondii impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation. Microbiol Spectr. 2025 Oct 07; 13(10):e0107425.
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Santoro JD, Eduthan NP, Khoshnood MM, Jafarpour S, Boyd NK, Vogel BN, Nguyen L, Kazerooni L, Britton E, Lyford HR, Galbraith MD, Rachubinski AL, Espinosa JM. Evidence of blood-brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder. Ann Clin Transl Neurol. 2025 Apr; 12(4):805-820.
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Matsuzaki H, Kai K, Komohara Y, Yano H, Pan C, Fujiwara Y, Yamada R, Iwauchi A, Fukasawa N, Tanaka T, Shimoda M, Watanabe H, Maruyama T, Takeo T, Mikami Y, Mukasa A. Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages. Cancer Sci. 2025 Apr; 116(4):897-909.
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Patel M, Panja S, Zaman LA, Yeapuri P, Bhattarai S, Gorantla S, Chang L, Heredia A, Walczak P, Hanson B, Cohen SM, Kevadiya BD, Gendelman HE. CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses. Nat Commun. 2025 Jan 08; 16(1):513.
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Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810.
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Martinez PJ, Song JJ, Castillo JI, DeSisto J, Song KH, Green AL, Borden M. Effect of Microbubble Size, Composition, and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening. ACS Biomater Sci Eng. 2024 Dec 09; 10(12):7451-7465.
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Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. Neuron. 2024 Sep 04; 112(17):2910-2921.e7.
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Ren L, Moreno D, Baer BR, Barbour P, Bettendorf T, Bouhana K, Brown K, Brown SA, Fell JB, Hartley DP, Hicken EJ, Laird ER, Lee P, McCown J, Otten JN, Prigaro B, Wallace R, Kahn D. Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer. J Med Chem. 2024 08 08; 67(15):13019-13032.
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Martinez PJ, Song JJ, Garay FG, Song KH, Mufford T, Steiner J, DeSisto J, Ellens N, Serkova NJ, Green AL, Borden M. Comprehensive assessment of blood-brain barrier opening and sterile inflammatory response: unraveling the therapeutic window. Sci Rep. 2024 07 24; 14(1):17036.
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Lemieux MR, Freigassner B, Hanson JL, Thathey Z, Opp MR, Hoeffer CA, Link CD. Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes. PLoS One. 2024; 19(6):e0303901.
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