 Blood-Brain Barrier
"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
| Descriptor ID |
D001812
|
| MeSH Number(s) |
A07.035 A08.186.211.035
|
| Concept/Terms |
Blood-Brain Barrier- Blood-Brain Barrier
- Barrier, Blood-Brain
- Barriers, Blood-Brain
- Blood Brain Barrier
- Blood-Brain Barriers
- Hemato-Encephalic Barrier
- Barrier, Hemato-Encephalic
- Barriers, Hemato-Encephalic
- Hemato Encephalic Barrier
- Hemato-Encephalic Barriers
- Brain-Blood Barrier
- Barrier, Brain-Blood
- Barriers, Brain-Blood
- Brain Blood Barrier
- Brain-Blood Barriers
|
Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".
Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".
This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 2 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 2 | 3 | 5 | | 2008 | 2 | 4 | 6 | | 2009 | 6 | 3 | 9 | | 2010 | 3 | 4 | 7 | | 2011 | 3 | 3 | 6 | | 2012 | 1 | 3 | 4 | | 2013 | 4 | 2 | 6 | | 2014 | 4 | 1 | 5 | | 2015 | 2 | 0 | 2 | | 2016 | 4 | 4 | 8 | | 2017 | 3 | 3 | 6 | | 2018 | 2 | 2 | 4 | | 2019 | 4 | 3 | 7 | | 2020 | 0 | 2 | 2 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 3 | 4 | | 2023 | 0 | 3 | 3 | | 2024 | 7 | 3 | 10 | | 2025 | 2 | 3 | 5 | | 2026 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.
-
Verhaege D, De Nolf C, Van Acker L, Claeys W, Castelein J, Van Wonterghem E, Van Imschoot G, Dujardin P, De Spiegelaere W, Hoste E, Boone F, Lidov HGW, Dani N, Derk J, Kremer A, Van Hamme E, Borghgraef P, Lippens S, Lehtinen MK, Siegenthaler J, Van Hoecke L, Vandenbroucke RE. Base barrier cells provide compartmentalization of choroid plexus, brain and CSF. Nat Neurosci. 2026 Mar; 29(3):551-566.
-
Han EL, Kim D, Murray AM, Mrksich K, Hamilton AG, Tang S, Yoo S, Zhu AT, Tong ER, Palanki R, Hall ML, Bedingfield SK, Mitchell MJ. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS Nano. 2026 Feb 03; 20(4):3807-3820.
-
Singh K, Foster MW, Violette MJ, Corcoran AM, Hotchkiss KM, Railton CO, Blandford EE, Blethen KE, Thomas EL, McIntosh WC, Ashley DM, Desjardins A, Friedman HS, Johnson MO, Friedman A, Keir S, Buckley ED, Herndon JE, McLendon RE, Sampson JH, Calabrese E, López GY, Grant GA, Patel AP, Gregory SG, Li CY, Fecci PE, Khasraw M. A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma. Sci Rep. 2025 Oct 23; 15(1):37112.
-
de Castro LL, Gomes da Rosa B, Peixoto-Rodrigues MC, Revoredo Vicentino AR, Fraga-Junior VdS, Cascabulho CM, Diniz LP, Benjamim CF, Bracko O, Scharfstein J, Adesse D. Toxoplasma gondii impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation. Microbiol Spectr. 2025 Oct 07; 13(10):e0107425.
-
Santoro JD, Eduthan NP, Khoshnood MM, Jafarpour S, Boyd NK, Vogel BN, Nguyen L, Kazerooni L, Britton E, Lyford HR, Galbraith MD, Rachubinski AL, Espinosa JM. Evidence of blood-brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder. Ann Clin Transl Neurol. 2025 Apr; 12(4):805-820.
-
Matsuzaki H, Kai K, Komohara Y, Yano H, Pan C, Fujiwara Y, Yamada R, Iwauchi A, Fukasawa N, Tanaka T, Shimoda M, Watanabe H, Maruyama T, Takeo T, Mikami Y, Mukasa A. Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages. Cancer Sci. 2025 Apr; 116(4):897-909.
-
Patel M, Panja S, Zaman LA, Yeapuri P, Bhattarai S, Gorantla S, Chang L, Heredia A, Walczak P, Hanson B, Cohen SM, Kevadiya BD, Gendelman HE. CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses. Nat Commun. 2025 Jan 08; 16(1):513.
-
Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810.
-
Martinez PJ, Song JJ, Castillo JI, DeSisto J, Song KH, Green AL, Borden M. Effect of Microbubble Size, Composition, and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening. ACS Biomater Sci Eng. 2024 Dec 09; 10(12):7451-7465.
-
Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. Neuron. 2024 Sep 04; 112(17):2910-2921.e7.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|