 TOR Serine-Threonine Kinases
"TOR Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
| Descriptor ID |
D058570
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| MeSH Number(s) |
D08.811.913.696.620.682.700.931 D12.776.476.925
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| Concept/Terms |
TOR Serine-Threonine Kinases- TOR Serine-Threonine Kinases
- Kinases, TOR Serine-Threonine
- Serine-Threonine Kinases, TOR
- TOR Serine Threonine Kinases
- Target of Rapamycin Proteins
- Rapamycin Proteins Target
- mTOR Serine-Threonine Kinases
- Kinases, mTOR Serine-Threonine
- Serine-Threonine Kinases, mTOR
- mTOR Serine Threonine Kinases
- Mechanistic Target of Rapamycin Protein
- FK506 Binding Protein 12-Rapamycin Associated Protein 1
- FK506 Binding Protein 12 Rapamycin Associated Protein 1
- TOR Kinases
- FKBP12-Rapamycin Associated Protein
- Associated Protein, FKBP12-Rapamycin
- FKBP12 Rapamycin Associated Protein
- Protein, FKBP12-Rapamycin Associated
- FKBP12-Rapamycin Complex-Associated Protein
- Complex-Associated Protein, FKBP12-Rapamycin
- FKBP12 Rapamycin Complex Associated Protein
- Protein, FKBP12-Rapamycin Complex-Associated
- RAFT-1 Protein
- Protein, RAFT-1
- RAFT 1 Protein
- Rapamycin Target Protein
- Protein, Rapamycin Target
- Target Protein, Rapamycin
- mTOR Protein
- Protein, mTOR
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Below are MeSH descriptors whose meaning is more general than "TOR Serine-Threonine Kinases".
Below are MeSH descriptors whose meaning is more specific than "TOR Serine-Threonine Kinases".
This graph shows the total number of publications written about "TOR Serine-Threonine Kinases" by people in this website by year, and whether "TOR Serine-Threonine Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 6 | 6 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 15 | 15 | | 2009 | 0 | 9 | 9 | | 2010 | 6 | 7 | 13 | | 2011 | 6 | 6 | 12 | | 2012 | 8 | 12 | 20 | | 2013 | 11 | 10 | 21 | | 2014 | 16 | 6 | 22 | | 2015 | 10 | 8 | 18 | | 2016 | 2 | 9 | 11 | | 2017 | 7 | 6 | 13 | | 2018 | 4 | 8 | 12 | | 2019 | 4 | 6 | 10 | | 2020 | 6 | 10 | 16 | | 2021 | 5 | 5 | 10 | | 2022 | 2 | 12 | 14 | | 2023 | 1 | 6 | 7 | | 2024 | 1 | 3 | 4 | | 2025 | 6 | 5 | 11 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "TOR Serine-Threonine Kinases" by people in Profiles.
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Rosario FJ, Shimada H, Fredrick SBJ, Barentsen K, Powell TL, Urschitz J, Brown TL, Brown L, Jansson T. Trophoblast-specific overexpression of Slc7a5 increases fetal amino acid availability and hepatic mTOR signalling and causes increased fetal growth. J Physiol. 2026 03; 604(5):2276-2301.
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Wang D, Ritz C, Luo Y, Suresh A, Pierce A, Veo B, Brunt B, Dahl N, Serkova N, Venkataraman S, Danis E, Kus K, Mazan M, Rzymski T, Vibhakar R. Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma. Nat Commun. 2025 Dec 16; 16(1):11152.
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Shimada H, Sakuragi T, Barentsen K, Erickson K, Urschitz J, Powell TL, Jansson T, Rosario FJ. Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression. Free Radic Biol Med. 2026 Feb 01; 243:276-290.
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Shimada H, Urschitz J, Powell TL, Jansson T, Rosario FJ. Inducible trophoblast-specific knockdown of mechanistic target of rapamycin impairs placental folate transport in mice. J Nutr Biochem. 2026 Mar; 149:110189.
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Rosario FJ, Urschitz J, Razavy H, Elston M, Powell TL, Jansson T. PiggyBac transposase-mediated inducible trophoblast-specific knockdown of Mtor decreases placental nutrient transport and fetal growth. Clin Sci (Lond). 2025 Jul 31; 139(14):825-845.
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Walker ZJ, Vaeth KF, Baldwin A, Ohlstrom DJ, Reiman LT, Dennis KA, Matlin K, Idler BM, Stevens BM, Mukherjee N, Sherbenou DW. Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine-Resistant Multiple Myeloma. Mol Cancer Res. 2025 Jul 02; 23(7):611-621.
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Atwood DJ, He Z, Miyazaki M, Hopp K, Jani A, Furgeson SB, Faubel S, Edelstein CL. mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney. Front Immunol. 2025; 16:1527817.
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Mather ML, Evangelou AV, Bourne JN, Macklin WB, Wood TL. Myelin Lipid Composition in the Central Nervous System Is Regionally Distinct and Requires Mechanistic Target of Rapamycin Signaling. Glia. 2025 Sep; 73(9):1841-1859.
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Sharma S, Rodems BJ, Baker CD, Kaszuba CM, Franco EI, Smith BR, Ito T, Swovick K, Welle K, Zhang Y, Rock P, Chaves FA, Ghaemmaghami S, Calvi LM, Ganguly A, Burack WR, Becker MW, Liesveld JL, Brookes PS, Munger JC, Jordan CT, Ashton JM, Bajaj J. Taurine from tumour niche drives glycolysis to promote leukaemogenesis. Nature. 2025 08; 644(8075):263-272.
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Nunes LGA, Weingrill RB, Fredrick SBJ, Lorca R, Lee MJ, Atif SM, Chicco AJ, Rosario FJ, Urschitz J. Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice. Acta Physiol (Oxf). 2025 Apr; 241(4):e70012.
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