 Granulocyte-Macrophage Colony-Stimulating Factor
"Granulocyte-Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
| Descriptor ID |
D016178
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| MeSH Number(s) |
D12.644.276.374.410.240.375 D12.776.395.240.300 D12.776.467.374.410.240.375 D23.529.374.410.240.375
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| Concept/Terms |
Granulocyte-Macrophage Colony-Stimulating Factor- Granulocyte-Macrophage Colony-Stimulating Factor
- Granulocyte Macrophage Colony Stimulating Factor
- CSF-2
- Tumor-Cell Human GM Colony-Stimulating Factor
- Tumor Cell Human GM Colony Stimulating Factor
- GM-CSF
- Histamine-Producing Cell-Stimulating Factor
- Cell-Stimulating Factor, Histamine-Producing
- Histamine Producing Cell Stimulating Factor
- TC-GM-CSF
- Colony-Stimulating Factor, Granulocyte-Macrophage
- Colony Stimulating Factor, Granulocyte Macrophage
- CSF-GM
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Below are MeSH descriptors whose meaning is more general than "Granulocyte-Macrophage Colony-Stimulating Factor".
Below are MeSH descriptors whose meaning is more specific than "Granulocyte-Macrophage Colony-Stimulating Factor".
This graph shows the total number of publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte-Macrophage Colony-Stimulating Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1994 | 0 | 4 | 4 | | 1995 | 2 | 3 | 5 | | 1996 | 0 | 1 | 1 | | 1998 | 0 | 4 | 4 | | 1999 | 1 | 1 | 2 | | 2000 | 0 | 2 | 2 | | 2002 | 3 | 0 | 3 | | 2003 | 1 | 2 | 3 | | 2004 | 1 | 6 | 7 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 0 | 2 | | 2007 | 1 | 1 | 2 | | 2008 | 3 | 2 | 5 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 1 | 2 | | 2011 | 0 | 3 | 3 | | 2012 | 1 | 3 | 4 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 3 | 0 | 3 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 2 | 3 | | 2021 | 2 | 0 | 2 | | 2022 | 1 | 3 | 4 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in Profiles.
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VanBuren JM, Hall M, Zuppa AF, Mourani PM, Carcillo J, Dean JM, Watt K, Holubkov R. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study. Pediatr Crit Care Med. 2023 Dec 01; 24(12):e635-e646.
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Stonedahl S, Leser JS, Clarke P, Potter H, Boyd TD, Tyler KL. Treatment with Granulocyte-Macrophage Colony-Stimulating Factor Reduces Viral Titers in the Brains of West Nile Virus-Infected Mice and Improves Survival. J Virol. 2023 03 30; 97(3):e0180522.
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Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022; 13:1072720.
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Lerman BJ, Li Y, Carlowicz C, Granger M, Cash T, Sadanand A, Somers K, Ranavaya A, Weiss BD, Choe M, Foster JH, Pinto N, Morgenstern DA, Rafael MS, Streby KA, Zeno RN, Mody R, Yazdani S, Desai AV, Macy ME, Shusterman S, Federico SM, Bagatell R. Progression-Free Survival and Patterns of Response in Patients With Relapsed High-Risk Neuroblastoma Treated With Irinotecan/Temozolomide/Dinutuximab/Granulocyte-Macrophage Colony-Stimulating Factor. J Clin Oncol. 2023 01 20; 41(3):508-516.
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Ahmed MM, Wang AC, Elos M, Chial HJ, Sillau S, Solano DA, Coughlan C, Aghili L, Anton P, Markham N, Adame V, Gardiner KJ, Boyd TD, Potter H. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice. Neurobiol Dis. 2022 06 15; 168:105694.
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Li Y, Qi X, Zhao D, Urban JF, Huang H. IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression. Cell Immunol. 2022 04; 374:104498.
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Ataya A, Knight V, Carey BC, Lee E, Tarling EJ, Wang T. The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front Immunol. 2021; 12:752856.
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Barqawi AB, Rodrigues Pessoa R, Crawford ED, Al-Musawi M, MacDermott T, O'Donell C, Kendl RM. Boosting immune response with GM-CSF optimizes primary cryotherapy outcomes in the treatment of prostate cancer: a prospective randomized clinical trial. Prostate Cancer Prostatic Dis. 2021 09; 24(3):750-757.
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Delaney C, Davizon-Castillo P, Allawzi A, Posey J, Gandjeva A, Neeves K, Tuder RM, Di Paola J, Stenmark KR, Nozik ES. Platelet activation contributes to hypoxia-induced inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 03 01; 320(3):L413-L421.
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Potter H, Boyd TD, Clarke P, Pelak VS, Tyler KL. Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19. F1000Res. 2020; 9:345.
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