 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 3 | 3 | 6 | | 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 9 | 6 | 15 | | 1999 | 6 | 5 | 11 | | 2000 | 9 | 2 | 11 | | 2001 | 4 | 5 | 9 | | 2002 | 9 | 6 | 15 | | 2003 | 8 | 4 | 12 | | 2004 | 11 | 8 | 19 | | 2005 | 13 | 10 | 23 | | 2006 | 15 | 12 | 27 | | 2007 | 14 | 14 | 28 | | 2008 | 17 | 7 | 24 | | 2009 | 18 | 6 | 24 | | 2010 | 13 | 15 | 28 | | 2011 | 20 | 11 | 31 | | 2012 | 15 | 16 | 31 | | 2013 | 18 | 9 | 27 | | 2014 | 32 | 16 | 48 | | 2015 | 16 | 12 | 28 | | 2016 | 12 | 14 | 26 | | 2017 | 17 | 14 | 31 | | 2018 | 9 | 8 | 17 | | 2019 | 19 | 14 | 33 | | 2020 | 11 | 6 | 17 | | 2021 | 15 | 15 | 30 | | 2022 | 3 | 11 | 14 | | 2023 | 1 | 11 | 12 | | 2024 | 5 | 9 | 14 | | 2025 | 6 | 6 | 12 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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He Z, Glass MC, Venkatesan P, Feser ML, Lazaro L, Okada LY, Tran NTT, He YD, Zaim SR, Bennett CE, Ravisankar P, Dornisch EM, Ferrannini AC, Arishi NA, Asamoah AG, Barzideh S, Becker LA, Bemis EA, Buckner JH, Collora CE, Criley MAL, Demoruelle MK, Fleischer CL, Garber J, Genge PC, Gong Q, Graybuck LT, Gustafson CE, Hattel BC, Hernandez V, Heubeck AT, Kawelo EK, Krishnan U, Kuan EL, Kuhn KA, LaFrance CM, Lee KJ, Li R, Lord C, Mettey RR, Moss L, Musgrove B, Nguyen KH, Ochoa A, Parthasarathy V, Pebworth MP, Pedrick C, Peng T, Phalen CG, Reading J, Roll CR, Seifert JA, Siedschlag MD, Speake C, Striebich CC, Stuckey TJ, Swanson EG, Takada H, Thai T, Thomson ZJ, Trieu N, Tsaltskan V, Wang W, Weiss MDA, Westermann A, Zhang F, Boyle DL, Goldrath AW, Bumol TF, Li XJ, Holers VM, Skene PJ, Savage AK, Firestein GS, Deane KD, Torgerson TR, Gillespie MA. Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation. Sci Transl Med. 2025 Sep 24; 17(817):eadt7214.
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Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025 Sep; 645(8080):496-506.
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Panja S, Zaman LA, Zhang C, Patel M, Gorantla S, Dash PK, Gendelman HE. Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV-1 Proviral DNA Excision. Adv Healthc Mater. 2025 Sep; 14(25):e2501190.
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Mann BT, Sanz M, Clohosey ML, Langlands K, Chitrakar A, Moreno-Soriano C, Vitalle J, Iannone MA, Ruiz-Mateos E, Deleage C, Siegel M, Soriano-Sarabia N. Dual role of circulating and mucosal Vd1 T cells in the control of and contribution to persistent HIV-1 infection. Nat Commun. 2025 Jul 01; 16(1):5817.
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Lanzar ZR, Aldridge DL, Jayaraman B, Haskins B, Howard CA, Arana K, Bunkofske ME, Mulka K, Pardy RD, Byerly J, Striepen B, Lupardus P, Hunter CA. De-coupling immune parameters and toxicity associated with IL-12 agonism. Cell Rep. 2025 Jun 24; 44(6):115840.
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Hohenstein AC, Gallegos JB, Dang M, Groegler J, Broncucia H, Tensun FA, Waugh K, Dong F, James EA, Speake C, Steck AK, Rewers MJ, Gottlieb PA, Haskins K, Delong T, Baker RL. Novel T-Cell Reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Individuals. Diabetes. 2025 Jun 01; 74(6):933-942.
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Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 May 22; 10(10).
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Teng KWW, Khoo WH, Ho NCW, Yang SJ, Wilson DC, Chua E, Ho SWS. Diving Deep: Profiling Exhausted T Cells in the Tumor Microenvironment Using Spectral Flow Cytometry. Cytometry A. 2025 Apr; 107(4):271-280.
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Jia X, Wenzlau JM, Zhang C, Dong F, Waugh K, Leslie RD, Rewers MJ, Michels AW, Yu L. Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes. Diabetes. 2025 Apr 01; 74(4):544-553.
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Molina PA, Edell CJ, Dunaway LS, Kellum CE, Muir RQ, Jennings MS, Colson JC, De Miguel C, Rhoads MK, Buzzelli AA, Harrington LE, Meza-Perez S, Randall TD, Botta D, Müller DN, Pollock DM, Maynard CL, Pollock JS. Aryl Hydrocarbon Receptor Activation Promotes Effector CD4+ T Cell Homeostasis and Restrains Salt-Sensitive Hypertension. Function (Oxf). 2025 Mar 24; 6(2).
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