 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 9 | 6 | 15 | | 1999 | 6 | 5 | 11 | | 2000 | 8 | 2 | 10 | | 2001 | 4 | 5 | 9 | | 2002 | 9 | 6 | 15 | | 2003 | 7 | 4 | 11 | | 2004 | 13 | 9 | 22 | | 2005 | 13 | 10 | 23 | | 2006 | 16 | 13 | 29 | | 2007 | 14 | 13 | 27 | | 2008 | 17 | 7 | 24 | | 2009 | 17 | 6 | 23 | | 2010 | 12 | 14 | 26 | | 2011 | 19 | 10 | 29 | | 2012 | 15 | 15 | 30 | | 2013 | 20 | 9 | 29 | | 2014 | 31 | 13 | 44 | | 2015 | 19 | 12 | 31 | | 2016 | 14 | 14 | 28 | | 2017 | 16 | 15 | 31 | | 2018 | 10 | 8 | 18 | | 2019 | 17 | 13 | 30 | | 2020 | 11 | 8 | 19 | | 2021 | 17 | 16 | 33 | | 2022 | 3 | 10 | 13 | | 2023 | 2 | 9 | 11 | | 2024 | 5 | 8 | 13 | | 2025 | 9 | 8 | 17 | | 2026 | 8 | 6 | 14 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Maeda K, Campbell PL, Wu Q, Tsou PS, Cooney LA, Mao-Draayer Y, Fox DA, Gurrea-Rubio M. Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation. Front Immunol. 2026; 17:1918840.
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Haskins K, Delong T, DiLisio JE, Baker RL. Hybrid Insulin Peptides as Antigens and Tolerogens for Pathogenic T Cells in Autoimmune Diabetes. Immunol Rev. 2026 Aug; 341(1):e70142.
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Wenzlau JM, Mangold K, Nicholson K, Dang M, Hohenstein AC, Douglas KS, DiLisio JE, Powell R, Delong T, Haskins K, Baker RL. A novel region of the insulin B9-23 sequence is targeted by a HIP-reactive diabetogenic T cell clone. Front Immunol. 2026; 17:1837267.
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King HAD, Subra C, Tourtellott E, Swafford I, Basu S, Rossman M, Phillips L, Obarorakpor N, Ding S, Ferrari MG, Beck Z, Lewitus E, Bai H, Dong M, Slike BM, Kim D, Dussupt V, Mendez-Rivera L, Eisel N, Zhang L, Williams LD, Tomaras GD, Finzi A, Matyas GR, Krebs SJ, Rolland M, Rao M, Paquin-Proulx D, Bolton DL. Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates. J Virol. 2026 Aug 18; 100(8):e0038926.
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Freeman ML, Fitzgerald W, Clagett BM, O'Hare KA, Jonnalagadda V, Wilson BM, Margolis L, Wu K, Tassiopoulos K, Shive CL, Erlandson KM. Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion. J Infect Dis. 2026 Jun 16; 233(6):995-1004.
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Moeser MJ, Council OD, Long N, Kincer L, Dennis AM, Eron J, Wohl D, Farel CE, Dittmer DP, Pluta L, Nelson J, Mohammadi A, Etemad B, Li JZ, McGann H, Smit E, Clement M, Yau T, Menezes P, Bowman NM, Zhou S, Joseph SB. A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage. J Infect Dis. 2026 Jun 16; 233(6):1005-1014.
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Falta MT, Raza M, Nevienski CJ, Brunetti TM, Fu R, Tucker RM, Gaballa JM, Minhajuddin F, Alula KM, Dinarello A, Mack DG, Martin AK, Onyiah JC, Yarnell M, Francis P, Fry TJ, Maier LA, Fontenot AP, Dinarello CA, Atif SM. Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell-treated mice. JCI Insight. 2026 Jul 22; 11(14).
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Bader CS, Killian S, Iliopoulou BP, Chen PI, Pathak S, Le CT, Villar-Prados A, Ji X, Jensen KP, Negrin RS, Meyer EH. Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy. Blood. 2026 05 21; 147(21):2489-2502.
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Buckley DJ, Zahedi S, Canizales A, Cuellar NE, Bogale K, Smith KA, Terrebonne KJ, Sharma S, Joseph B, Greaney JL, Trott DW. CD8+ T cells contribute to arterial aging in mice. J Immunol. 2026 Apr 15; 215(4).
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Zarrella KM, Sheridan RM, Ware BC, Davenport BJ, da Silva MOL, Vyshenska D, Martin AU, May NA, Fish ER, Weiskopf D, Hesselberth JR, Streblow DN, Greninger AL, Morrison TE. Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice. Nat Microbiol. 2026 May; 11(5):1302-1317.
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