 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 9 | 6 | 15 | | 1999 | 6 | 5 | 11 | | 2000 | 8 | 2 | 10 | | 2001 | 4 | 5 | 9 | | 2002 | 9 | 6 | 15 | | 2003 | 7 | 4 | 11 | | 2004 | 12 | 8 | 20 | | 2005 | 13 | 10 | 23 | | 2006 | 16 | 12 | 28 | | 2007 | 14 | 13 | 27 | | 2008 | 16 | 7 | 23 | | 2009 | 17 | 6 | 23 | | 2010 | 12 | 15 | 27 | | 2011 | 19 | 10 | 29 | | 2012 | 15 | 15 | 30 | | 2013 | 19 | 9 | 28 | | 2014 | 32 | 15 | 47 | | 2015 | 16 | 12 | 28 | | 2016 | 14 | 14 | 28 | | 2017 | 17 | 14 | 31 | | 2018 | 10 | 8 | 18 | | 2019 | 19 | 14 | 33 | | 2020 | 11 | 7 | 18 | | 2021 | 16 | 15 | 31 | | 2022 | 3 | 11 | 14 | | 2023 | 1 | 12 | 13 | | 2024 | 5 | 9 | 14 | | 2025 | 9 | 8 | 17 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Mann BT, Sanz M, Chitrakar A, Langlands K, Siegel M, Soriano-Sarabia N. Ex vivo-expanded allogeneic Vd2 T cells specifically reduce reservoirs of HIV-1 following latency reversal. JCI Insight. 2026 Mar 23; 11(6).
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Lenkala D, Kohler J, McCarthy B, Nelson M, Bakker NAM, de Boer R, Jackson EK, Sheen JHF, Hannes S, Esaulova E, Stewart K, Gottstein C, Attanasio J, Brown FD, Hymson S, Meda S, van Zon M, Scheij S, Voogd R, Raud B, Xu Z, Borgers JSW, Rohaan MW, Balogh KN, Poran A, Rooney M, Dong JZ, Srouji JR, Juneja VR, Arieta CM, Nijenhuis CM, Nuijen B, DeMario M, Manson K, Schumacher TNM, Gaynor RB, Haanen JB, van den Berg JH, van Buuren MM. NEO-STIM advances personalized neoantigen-specific adoptive T cell therapy. Nat Commun. 2026 Feb 05; 17(1).
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Groegler J, Mangold K, Nicholson K, Dang M, Wenzlau J, Beard KS, Hohenstein A, Powell R, Baker R, Haskins K, Matsuda J, Delong T. Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice. Diabetes. 2026 Jan 01; 75(1):115-123.
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Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.
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Mickael C, Kumar R, Fonseca Balladares DC, Nolan K, Lee MH, Kassa B, Menezes TCF, Lau-Xiao A, Sahota A, Sanders L, Tuscan K, Gandjeva A, Cautivo KM, Molofsky A, Graham BB. Role of conventional dendritic cells in schistosomiasis-induced pulmonary hypertension. Clin Sci (Lond). 2025 Oct 14; 139(20).
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He Z, Glass MC, Venkatesan P, Feser ML, Lazaro L, Okada LY, Tran NTT, He YD, Zaim SR, Bennett CE, Ravisankar P, Dornisch EM, Ferrannini AC, Arishi NA, Asamoah AG, Barzideh S, Becker LA, Bemis EA, Buckner JH, Collora CE, Criley MAL, Demoruelle MK, Fleischer CL, Garber J, Genge PC, Gong Q, Graybuck LT, Gustafson CE, Hattel BC, Hernandez V, Heubeck AT, Kawelo EK, Krishnan U, Kuan EL, Kuhn KA, LaFrance CM, Lee KJ, Li R, Lord C, Mettey RR, Moss L, Musgrove B, Nguyen KH, Ochoa A, Parthasarathy V, Pebworth MP, Pedrick C, Peng T, Phalen CG, Reading J, Roll CR, Seifert JA, Siedschlag MD, Speake C, Striebich CC, Stuckey TJ, Swanson EG, Takada H, Thai T, Thomson ZJ, Trieu N, Tsaltskan V, Wang W, Weiss MDA, Westermann A, Zhang F, Boyle DL, Goldrath AW, Bumol TF, Li XJ, Holers VM, Skene PJ, Savage AK, Firestein GS, Deane KD, Torgerson TR, Gillespie MA. Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation. Sci Transl Med. 2025 Sep 24; 17(817):eadt7214.
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Slack SD, Esquinca E, Arehart CH, Boorgula MP, Szczesny B, Romero A, Campbell M, Chavan S, Rafaels N, Watson H, Landis RC, Hansel NN, Rotimi CN, Olopade CO, Figueiredo CA, Ober C, Liu AH, Kenny EE, Kammers K, Ruczinski I, Taub MA, Daya M, Gignoux CR, Kechris K, Barnes KC, Mathias RA, Johnson RK. Prediction and characterization of genetically regulated expression of asthma tissues from African-ancestry populations. J Allergy Clin Immunol. 2026 Jan; 157(1):253-261.
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Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, Pant S, O'Reilly EM. Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results. Nat Med. 2025 Nov; 31(11):3648-3653.
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Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025 09; 645(8080):496-506.
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Jaquish A, Phung E, Gong X, Baldominos P, Galván-Peña S, Magill I, Bursulaya I, Marina E, Bertrand K, Chambers C, Muñoz-Rojas AR, Agudo J, Mathis D, Benoist C, Ramanan D. Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis. Nat Immunol. 2025 Aug; 26(8):1411-1422.
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