 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
|
| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
|
| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
|
Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 9 | 6 | 15 | | 1999 | 6 | 5 | 11 | | 2000 | 8 | 2 | 10 | | 2001 | 4 | 5 | 9 | | 2002 | 9 | 6 | 15 | | 2003 | 7 | 4 | 11 | | 2004 | 13 | 9 | 22 | | 2005 | 13 | 10 | 23 | | 2006 | 16 | 11 | 27 | | 2007 | 14 | 13 | 27 | | 2008 | 16 | 7 | 23 | | 2009 | 17 | 6 | 23 | | 2010 | 12 | 15 | 27 | | 2011 | 19 | 10 | 29 | | 2012 | 15 | 15 | 30 | | 2013 | 21 | 9 | 30 | | 2014 | 32 | 15 | 47 | | 2015 | 17 | 12 | 29 | | 2016 | 14 | 14 | 28 | | 2017 | 17 | 14 | 31 | | 2018 | 10 | 9 | 19 | | 2019 | 19 | 14 | 33 | | 2020 | 11 | 8 | 19 | | 2021 | 17 | 16 | 33 | | 2022 | 3 | 11 | 14 | | 2023 | 2 | 10 | 12 | | 2024 | 5 | 9 | 14 | | 2025 | 9 | 8 | 17 | | 2026 | 4 | 4 | 8 |
To return to the timeline, click here.
Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
-
Haskins K, Delong T, DiLisio JE, Baker RL. Hybrid Insulin Peptides as Antigens and Tolerogens for Pathogenic T Cells in Autoimmune Diabetes. Immunol Rev. 2026 Aug; 341(1):e70142.
-
Freeman ML, Fitzgerald W, Clagett BM, O'Hare KA, Jonnalagadda V, Wilson BM, Margolis L, Wu K, Tassiopoulos K, Shive CL, Erlandson KM. Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion. J Infect Dis. 2026 Jun 16; 233(6):995-1004.
-
Buckley DJ, Zahedi S, Canizales A, Cuellar NE, Bogale K, Smith KA, Terrebonne KJ, Sharma S, Joseph B, Greaney JL, Trott DW. CD8+ T cells contribute to arterial aging in mice. J Immunol. 2026 Apr 15; 215(4).
-
Zarrella KM, Sheridan RM, Ware BC, Davenport BJ, da Silva MOL, Vyshenska D, Martin AU, May NA, Fish ER, Weiskopf D, Hesselberth JR, Streblow DN, Greninger AL, Morrison TE. Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice. Nat Microbiol. 2026 May; 11(5):1302-1317.
-
DiLisio JE, Beard KS, Neef T, Miller SD, Wenzlau JM, Nakayama M, D'Antonio MA, Jamison BL, Nicholson KS, Baker RL, Brunetti TM, Gapin L, Haskins K. Antigen-specific immunotherapy with a CD4+ T cell neoepitope restrains CD8+ T cell differentiation in murine pancreatic islet grafts. Nat Commun. 2026 Mar 24; 17(1).
-
Mickens KL, Dillon SM, Guo K, Wilson CC, Santiago ML. Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence. Curr HIV/AIDS Rep. 2026 Feb 16; 23(1):5.
-
Mann BT, Sanz M, Chitrakar A, Langlands K, Siegel M, Soriano-Sarabia N. Ex vivo-expanded allogeneic Vd2 T cells specifically reduce reservoirs of HIV-1 following latency reversal. JCI Insight. 2026 Mar 23; 11(6).
-
Lenkala D, Kohler J, McCarthy B, Nelson M, Bakker NAM, de Boer R, Jackson EK, Sheen JHF, Hannes S, Esaulova E, Stewart K, Gottstein C, Attanasio J, Brown FD, Hymson S, Meda S, van Zon M, Scheij S, Voogd R, Raud B, Xu Z, Borgers JSW, Rohaan MW, Balogh KN, Poran A, Rooney M, Dong JZ, Srouji JR, Juneja VR, Arieta CM, Nijenhuis CM, Nuijen B, DeMario M, Manson K, Schumacher TNM, Gaynor RB, Haanen JB, van den Berg JH, van Buuren MM. NEO-STIM advances personalized neoantigen-specific adoptive T cell therapy. Nat Commun. 2026 Feb 05; 17(1).
-
Groegler J, Mangold K, Nicholson K, Dang M, Wenzlau J, Beard KS, Hohenstein A, Powell R, Baker R, Haskins K, Matsuda J, Delong T. Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice. Diabetes. 2026 01 01; 75(1):115-123.
-
Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|