 Autophagy
"Autophagy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The segregation and degradation of cytoplasmic constituents by AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.
| Descriptor ID |
D001343
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| MeSH Number(s) |
G04.146.399 G04.417.350.091
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| Concept/Terms |
Autophagy- Autophagy
- Autophagies
- Macro-autophagy
- Macro autophagy
- Macro-autophagies
- Autophagy, Cellular
- Autophagies, Cellular
- Cellular Autophagies
- Cellular Autophagy
- Macroautophagy
- Macroautophagies
- Autophagocytosis
Programmed Cell Death, Type II- Programmed Cell Death, Type II
- Autophagic Cell Death
- Autophagic Cell Deaths
- Cell Death, Autophagic
- Cell Deaths, Autophagic
- Death, Autophagic Cell
- Deaths, Autophagic Cell
- Autophagic Programmed Cell Death
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Below are MeSH descriptors whose meaning is more general than "Autophagy".
Below are MeSH descriptors whose meaning is more specific than "Autophagy".
This graph shows the total number of publications written about "Autophagy" by people in this website by year, and whether "Autophagy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 2 | 4 | | 2010 | 1 | 2 | 3 | | 2011 | 4 | 3 | 7 | | 2012 | 5 | 4 | 9 | | 2013 | 11 | 6 | 17 | | 2014 | 14 | 6 | 20 | | 2015 | 3 | 3 | 6 | | 2016 | 10 | 3 | 13 | | 2017 | 8 | 6 | 14 | | 2018 | 8 | 4 | 12 | | 2019 | 10 | 6 | 16 | | 2020 | 6 | 4 | 10 | | 2021 | 7 | 3 | 10 | | 2022 | 2 | 7 | 9 | | 2023 | 0 | 6 | 6 | | 2024 | 4 | 3 | 7 | | 2025 | 4 | 4 | 8 |
To return to the timeline, click here.
Below are the most recent publications written about "Autophagy" by people in Profiles.
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Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T. Evidence that mitochondria in macrophages are destroyed by microautophagy. Nat Commun. 2025 Aug 30; 16(1):8123.
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Matthews AM, Whiteley AM. UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential. Biochem Soc Trans. 2025 Aug 29; 53(4):823-833.
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Peddaboina C, Iannucci J, Tobin RP, Shapiro LA, Newell Rogers MK. Autophagy Differentially Influences Toll-like Receptor 9 and B Cell-Receptor-Mediated B Cell Expansion, Expression of Major Histocompatibility Class II Proteins, and Antigenic Peptide Presentation. Int J Mol Sci. 2025 Jun 24; 26(13).
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Martin TG, Langer SJ, Crocini C, Chung E, Leinwand LA. Activation of FoxO1 prevents and reverses cardiac hypertrophy from diverse stimuli. J Mol Cell Cardiol. 2025 Aug; 205:62-67.
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Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNF-a impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation. J Clin Invest. 2025 Aug 01; 135(15).
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Riccardi V, Viscomi CF, Sandri M, D'Alessandro A, Dzieciatkowska M, Stephenson D, Federti E, Hermann A, Salviati L, Siciliano A, Andolfo I, Alper SL, Ceolan J, Iolascon A, Vattemi G, Danek A, Walker RH, Mensch A, Otto M, Deschauer M, Armbrust M, Beninca' C, Salari V, Fabene P, Peikert K, De Franceschi L. Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy. Acta Neuropathol Commun. 2025 04 24; 13(1):83.
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Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC. The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection. Nat Commun. 2025 Mar 25; 16(1):2923.
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Wang S, Xue D. Asymmetric partitioning of persistent paternal mitochondria during cell divisions safeguards embryo development and mitochondrial inheritance. Dev Cell. 2025 Jun 23; 60(12):1730-1750.e10.
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Martin TG, Hunt DR, Langer SJ, Tan Y, Ebmeier CC, Leinwand LA. Regression of postprandial cardiac hypertrophy in burmese pythons is mediated by FoxO1. Proc Natl Acad Sci U S A. 2024 Oct 08; 121(41):e2408719121.
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Atwood D, He Z, Miyazaki M, Hailu F, Klawitter J, Edelstein CL. Early treatment with 2-deoxy-d-glucose reduces proliferative proteins in the kidney and slows cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease (PKD). Cell Signal. 2024 11; 123:111351.
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