 Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
| Descriptor ID |
D046988
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| MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
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| Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- Proteasome
- 20S Proteasome
- Proteasome, 20S
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
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Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 2000 | 0 | 6 | 6 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 4 | 4 | | 2004 | 1 | 4 | 5 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 5 | 6 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 4 | 5 | | 2009 | 4 | 2 | 6 | | 2010 | 4 | 2 | 6 | | 2011 | 2 | 6 | 8 | | 2012 | 0 | 8 | 8 | | 2013 | 1 | 2 | 3 | | 2014 | 1 | 4 | 5 | | 2015 | 0 | 6 | 6 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 3 | 3 | | 2018 | 2 | 1 | 3 | | 2019 | 3 | 0 | 3 | | 2020 | 2 | 2 | 4 | | 2022 | 3 | 4 | 7 | | 2023 | 0 | 2 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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Das E, Le L, Sokolova V, Orth JD, Park S. Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome. Nat Commun. 2025 Apr 09; 16(1):3358.
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Schaunaman N, Cervantes D, Ferrington DA, Chu HW. Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness. Front Immunol. 2025; 16:1501898.
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Brown MT, McMurray MA. Stepwise order in protein complex assembly: approaches and emerging themes. Open Biol. 2025 Jan; 15(1):240283.
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Schaunaman N, Nichols T, Cervantes D, Hartsoe P, Ferrington DA, Chu HW. The Effect of a TLR3 Agonist on Airway Allergic Inflammation and Viral Infection in Immunoproteasome-Deficient Mice. Viruses. 2024 08 29; 16(9).
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Kelley ME, Berman AY, Stirling DR, Cimini BA, Han Y, Singh S, Carpenter AE, Kapoor TM, Way GP. High-content microscopy reveals a morphological signature of bortezomib resistance. Elife. 2023 09 27; 12.
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Ludwig MP, Galbraith MD, Eduthan NP, Hill AA, Clay MR, Tellez CM, Wilky BA, Elias A, Espinosa JM, Sullivan KD. Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway. Cancer Res. 2023 08 01; 83(15):2543-2556.
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Zegallai HM, Abu-El-Rub E, Mejia EM, Sparagna GC, Cole LK, Marshall AJ, Hatch GM. Tafazzin deficiency attenuates anti-cluster of differentiation 40 and interleukin-4 activation of mouse B lymphocytes. Cell Tissue Res. 2022 Dec; 390(3):429-439.
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Jim?nez-Segura R, Rosi?ol L, Cibeira MT, Fern?ndez de Larrea C, Tovar N, Rodr?guez-Lobato LG, Blad? E, Moreno DF, Oliver-Cald?s A, Blad? J. Paraskeletal and extramedullary plasmacytomas in multiple myeloma at diagnosis and at first relapse: 50-years of experience from an academic institution. Blood Cancer J. 2022 09 16; 12(9):135.
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Reed CH, Buhr TJ, Tystahl AC, Bauer EE, Clark PJ, Valentine RJ. The effects of voluntary binge-patterned ethanol ingestion and daily wheel running on signaling of muscle protein synthesis and degradation in female mice. Alcohol. 2022 11; 104:45-52.
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Hogrel G, Marino-Puertas L, Laurent S, Ibrahim Z, Cov?s J, Girard E, Gabel F, Fenel D, Daugeron MC, Clouet-d'Orval B, Basta T, Flament D, Franzetti B. Characterization of a small tRNA-binding protein that interacts with the archaeal proteasome complex. Mol Microbiol. 2022 07; 118(1-2):16-29.
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