Heterozygote
"Heterozygote" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An individual having different alleles at one or more loci regarding a specific character.
| Descriptor ID |
D006579
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| MeSH Number(s) |
G05.380.383
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| Concept/Terms |
Genetic Carriers- Genetic Carriers
- Carrier, Genetic
- Genetic Carrier
- Carriers, Genetic
|
Below are MeSH descriptors whose meaning is more general than "Heterozygote".
Below are MeSH descriptors whose meaning is more specific than "Heterozygote".
This graph shows the total number of publications written about "Heterozygote" by people in this website by year, and whether "Heterozygote" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 6 | 6 | | 2001 | 1 | 5 | 6 | | 2002 | 2 | 2 | 4 | | 2003 | 1 | 4 | 5 | | 2004 | 1 | 7 | 8 | | 2005 | 0 | 6 | 6 | | 2006 | 1 | 7 | 8 | | 2007 | 2 | 8 | 10 | | 2008 | 0 | 11 | 11 | | 2009 | 1 | 5 | 6 | | 2010 | 0 | 5 | 5 | | 2011 | 2 | 9 | 11 | | 2012 | 1 | 8 | 9 | | 2013 | 2 | 7 | 9 | | 2014 | 4 | 13 | 17 | | 2015 | 3 | 12 | 15 | | 2016 | 2 | 12 | 14 | | 2017 | 1 | 13 | 14 | | 2018 | 1 | 6 | 7 | | 2019 | 3 | 6 | 9 | | 2020 | 2 | 11 | 13 | | 2021 | 1 | 7 | 8 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 3 | 8 | 11 | | 2025 | 0 | 9 | 9 | | 2026 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Heterozygote" by people in Profiles.
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Nicholls SJ, Nelson AJ, Ditmarsch M, Kastelein JJP, Ballantyne CM, Ray KK, Navar AM, Nissen SE, Goldberg AC, Brunham LR, Wuerdeman E, Neild AL, Kling D, Hsieh A, Butters J, Ference BA, Laufs U, Banach M, Mehran R, Catapano AL, Szarek M, Balinskaite V, Davidson MH. Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial. Nat Med. 2026 Mar; 32(3):1052-1060.
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Haanpää MK, Haldeman-Englert CR, Hietala M, Tanverdi MS, Koty PP, Brightman D, Dosunmu E, Tibrewal S, Kaur S, Kaur A, Verma RK, de Alba Campomanes AG, Utz V, Slavotinek AM, Curry C. Nance-Horan Syndrome: Further Delineation of the Affected Male and the Female Carrier Phenotypes. Am J Med Genet A. 2026 Mar; 200(3):642-652.
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Geba GP, Mohammadi KA, Damask A, Paulding C, Lotta LA, Hindy G, Pordy R, Manvelian G, Shapiro MD, Bittner VA, Bhatt DL, Szarek M, Schwartz GG, Steg PG, Fazio S. Effect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial. J Am Heart Assoc. 2025 Sep 02; 14(17):e041190.
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Wilder AP, Shier DM, King SND, Dudchenko O, Funk ER, Misuraca A, Houck ML, Miller WB, Curry CJ, Fronczek J, Khan R, Weisz D, Fisher RN, Lieberman Aiden E, Ryder OA, Steiner CC. Fitness benefits of genetic rescue despite chromosomal differences in an endangered pocket mouse. Science. 2025 Aug 21; 389(6762):835-839.
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van Peer SE, Treger TD, Wegert J, Hol JA, Le Gall J, Jakkula EE, Kamihara J, Mullen EA, Graf N, Behjati S, Al-Saadi R, Duncan C, Schienda J, de Putter R, Brzezinski J, Verschuur A, Michaeli O, Ortiz MV, Herkert JC, Armstrong R, Waanders E, Kuiper RP, van den Heuvel-Eibrink MM, Gessler M, Jongmans MCJ. Wilms tumor characteristics in children with heterozygous germline DIS3L2 variants. Genet Med. 2025 Sep; 27(9):101478.
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Montani D, McLaughlin VV, Gibbs JSR, Gomberg-Maitland M, Hoeper MM, Preston IR, Souza R, Waxman AB, Escribano Subias P, Feldman J, Meyer GM, Olsson KM, Coulet F, Manimaran S, Zhao Y, Lau A, de Oliveira Pena J, Badesch DB, Humbert M. Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR). Am J Respir Crit Care Med. 2025 Jun; 211(6):1028-1037.
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Gigli M, Stolfo D, Barbati G, Graw S, Chen SN, Merlo M, Medo K, Gregorio C, Dal Ferro M, Paldino A, Perotto M, Peter van Tintelen J, Te Riele ASJM, Baas AF, Wilde AM, Amin AS, Houweling AC, Elliott P, Cannie D, Michels M, Schoonvelde SAC, Prasad S, Tayal PU, Yazdani M, Morris-Rosendahl D, Garcia-Pavia P, Cabrera-Romero E, Bauce B, Pilichou K, Fatkin D, Johnson R, Judge DP, Foil KL, Heymans S, Verdonschot JAJ, Stroeks SLVM, Lakdawala NK, Anisha P, O'Neill M, Shoemaker MB, Roden DM, Calkins H, James CA, Murray B, Parikh VN, Ashley EA, Reuter C, Imazio M, Canepa M, Ameri P, Song J, Sinagra G, Taylor MRG, Mestroni L. Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants. JAMA Cardiol. 2025 Apr 01; 10(4):359-369.
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Yamazaki S, Kaneko S, Shimbo A, Irabu H, Ogino R, Miyamoto T, Izawa K, Segawa Y, Kakizaki J, Mori M, Shimizu M. Overlapping Aicardi-Goutières and Singleton-Merten syndromes with a heterozygous gain-of-function mutation in IFIH1 mimicking juvenile idiopathic arthritis. Immunol Med. 2025 Sep; 48(3):256-260.
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Gasperetti A, Carrick RT, Protonotarios A, Murray B, Laredo M, van der Schaaf I, Lekanne RH, Syrris P, Cannie D, Tichnell C, Cappelletto C, Gigli M, Medo K, Saguner AM, Duru F, Gilotra NA, Zimmerman S, Hylind R, Abrams DJ, Lakdawala NK, Cadrin-Tourigny J, Targetti M, Olivotto I, Graziosi M, Cox M, Biagini E, Charron P, Casella M, Tondo C, Yazdani M, Ware JS, Prasad SK, Calò L, Smith ED, Helms AS, Hespe S, Ingles J, Tandri H, Ader F, Peretto G, Peters S, Horton A, Yao J, Dittmann S, Schulze-Bahr E, Qureshi M, Young K, Carruth ED, Haggerty C, Parikh VN, Taylor M, Mestroni L, Wilde A, Sinagra G, Merlo M, Gandjbakhch E, van Tintelen JP, Te Riele ASJM, Elliott PM, Calkins H, James CA. Clinical features and outcomes in carriers of pathogenic desmoplakin variants. Eur Heart J. 2025 Jan 21; 46(4):362-376.
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Üzen R, Bayram F, Dursun H, Kardas F, Cakir M, Sohel MMH, Cucer N, Eken A, Donmez-Altuntas H. Tumor Suppressor and Oncogenic miRNA Expressions in Patients with Type I Gaucher Disease and Carriers. Microrna. 2025; 14(3):246-253.
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