 Protein Binding
"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
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| MeSH Number(s) |
G02.111.679 G03.808
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 17 | 17 | | 1997 | 1 | 16 | 17 | | 1998 | 0 | 21 | 21 | | 1999 | 0 | 12 | 12 | | 2000 | 0 | 28 | 28 | | 2001 | 0 | 39 | 39 | | 2002 | 0 | 50 | 50 | | 2003 | 0 | 37 | 37 | | 2004 | 1 | 44 | 45 | | 2005 | 0 | 66 | 66 | | 2006 | 0 | 65 | 65 | | 2007 | 0 | 53 | 53 | | 2008 | 1 | 62 | 63 | | 2009 | 0 | 63 | 63 | | 2010 | 0 | 67 | 67 | | 2011 | 1 | 91 | 92 | | 2012 | 0 | 89 | 89 | | 2013 | 2 | 87 | 89 | | 2014 | 0 | 72 | 72 | | 2015 | 2 | 66 | 68 | | 2016 | 0 | 93 | 93 | | 2017 | 0 | 78 | 78 | | 2018 | 3 | 81 | 84 | | 2019 | 0 | 65 | 65 | | 2020 | 0 | 75 | 75 | | 2021 | 2 | 42 | 44 | | 2022 | 0 | 21 | 21 | | 2023 | 0 | 17 | 17 | | 2024 | 10 | 39 | 49 | | 2025 | 0 | 49 | 49 | | 2026 | 0 | 22 | 22 |
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Below are the most recent publications written about "Protein Binding" by people in Profiles.
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Lee E, Redzic JS, Sarkar S, Rivkin D, Gordon B, Saviola AJ, Maroney SP, Thorstenson JC, Hansen KC, Horswill A, Hamelberg D, Eisenmesser E. N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases. Sci Adv. 2026 Jul 24; 12(30):eaeh5197.
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Kotz J, Martz EJ, Nelson M, Savoie N, Schmitt L, States J, Holton N, Guillen D, Kasinath V, Hansen K, Johnson AM. Physical interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression. Cell Rep. 2026 Jul 28; 45(7):117564.
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McAllister RA, Stiegler AL, Chari K, Chari M, Bhattacharyya M, Gupta K. Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation. Proc Natl Acad Sci U S A. 2026 Jul 07; 123(27):e2528109123.
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Van Gundy T, Schneider C, Ebmeier CC, Chambers GZ, Cramer NA, Chambers KM, Drecktrah D, Hyde JA, Skare JT, Marconi RT, Samuels DS, Lybecker MC. Identification of proteins exhibiting in vitro RNA chaperone activity through gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi. RNA Biol. 2026 Dec; 23(1):1-23.
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Lee YH, Rinn JL, Hwang T. Protocol for massively parallel RNA assay combined with immunoprecipitation for high-throughput analysis of RNA-protein interactions in cells. STAR Protoc. 2026 Jun 19; 7(2):104624.
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Li X, Li J, Shi S, Kuang Z, Srivastava P, Issaian A, Bevers S, Wagley ME, D'Alessandro A, Zhao R. U1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast. Nucleic Acids Res. 2026 Jun 08; 54(11).
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Yang D, Wang X, Liu J, Gong Y, Nair P, Sun J, Qian X, Cui J, Zeng H, Dong A, Harding RJ, Burgess-Brown N, Beyett TS, Song D, Krause HM, Diamond ML, Bolhuis DL, Brown NG, Arrowsmith CH, Edwards AM, Halabelian L, Peng H. High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds. Proc Natl Acad Sci U S A. 2026 Jun 23; 123(25):e2515940123.
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Mead EH, Batz KC, Shih KH, Fleming IR, Tesdahl CD, Lizardos L, Armendariz JR, Hannan JP, Hickey AM, Leyk A, Erbse AH, Falke JJ. COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3K?RBD Frequently Generate Affinity Increases. Biochemistry. 2026 06 02; 65(11):1749-1754.
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Larsen ME, Barker CM, Vargas RS, Coultrap SJ, Bayer KU. The CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding. Mol Pharmacol. 2026 May-Jun; 108(5-6):100127.
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Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich KJ, Erbse AH, Kasinath V, Cech TR. RNA-induced PRC2 inhibition depends on the sequence of bound RNA. Nat Commun. 2026 Apr 23; 17(1).
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