 Protein Binding
"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
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| MeSH Number(s) |
G02.111.679 G03.808
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 16 | 16 | | 1997 | 1 | 15 | 16 | | 1998 | 0 | 21 | 21 | | 1999 | 0 | 13 | 13 | | 2000 | 0 | 28 | 28 | | 2001 | 0 | 38 | 38 | | 2002 | 0 | 48 | 48 | | 2003 | 0 | 37 | 37 | | 2004 | 1 | 45 | 46 | | 2005 | 0 | 65 | 65 | | 2006 | 0 | 63 | 63 | | 2007 | 0 | 52 | 52 | | 2008 | 1 | 60 | 61 | | 2009 | 0 | 61 | 61 | | 2010 | 0 | 68 | 68 | | 2011 | 1 | 91 | 92 | | 2012 | 0 | 92 | 92 | | 2013 | 2 | 85 | 87 | | 2014 | 0 | 69 | 69 | | 2015 | 2 | 64 | 66 | | 2016 | 0 | 92 | 92 | | 2017 | 0 | 77 | 77 | | 2018 | 2 | 77 | 79 | | 2019 | 0 | 65 | 65 | | 2020 | 0 | 70 | 70 | | 2021 | 2 | 40 | 42 | | 2022 | 0 | 20 | 20 | | 2023 | 0 | 17 | 17 | | 2024 | 11 | 39 | 50 | | 2025 | 0 | 48 | 48 | | 2026 | 0 | 30 | 30 |
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Below are the most recent publications written about "Protein Binding" by people in Profiles.
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Peter JA, Weiser TA, Niswander LA, Batey RT, Wuttke DS. MeCP2 MBD-ID module: a unified DNA/RNA binding interface disrupted in Rett syndrome. Nucleic Acids Res. 2026 Sep 22; 54(18).
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Friedman AJ, Fox JM, Shirts MR. Improving Sampling of Binding Free Energy Differences between Covalently Bound Ligands in Alternate Binding Pockets Using MT-REXEE. J Chem Theory Comput. 2026 Aug 11; 22(15):7788-7800.
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Clements CM, Roney MSI, Shellman YG. SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics. Int J Mol Sci. 2026 Aug 06; 27(15).
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Selvakumar P, Swartz KJ, Fernández-Mariño AI. Nanobody regulation of C-type inactivation in Kv1.3 channels. Nat Commun. 2026 08 04; 17(1).
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Wilhelm FM, Pluhackova K, Janetzko J, Masureel M, Marsh E, Hudspeth J, Gaßner W, Schertler GFX, Kobilka BK, Müller DJ. Factors modulating the assembly of human ß2-adrenergic receptor-ß-arrestin complexes. Nat Struct Mol Biol. 2026 Aug; 33(8):1158-1170.
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Lee E, Redzic JS, Sarkar S, Rivkin D, Gordon B, Saviola AJ, Maroney SP, Thorstenson JC, Hansen KC, Horswill AR, Hamelberg D, Eisenmesser E. N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases. Sci Adv. 2026 07 24; 12(30):eaeh5197.
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Kuang Z, Kosmyna B, Li X, Tang Z, Shi S, Lambert K, Zhang W, Giovinazzo J, Effenberger KA, Sierra J, Ying L, Barraza SJ, Li W, Wang J, Trotta CR, Zhao R. The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function. Nat Commun. 2026 Jul 16; 17(1).
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Gaurav N, Ebert LK, Lachance C, Selvam K, Chen RW, Qin W, Pozharskaia V, Chi C, Côté V, Cox KL, Fuchs HA, Musselman CA, Leonhardt H, Morral N, Song K, Poirier MG, Côté J, Schermer B, Kutateladze TG. Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex. Nat Commun. 2026 Jul 11; 17(1).
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Kotz J, Martz EJ, Nelson M, Savoie N, Schmitt L, States J, Holton N, Guillen D, Kasinath V, Hansen K, Johnson AM. Physical interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression. Cell Rep. 2026 Jul 28; 45(7):117564.
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McAllister RA, Stiegler AL, Chari K, Chari M, Bhattacharyya M, Gupta K. Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation. Proc Natl Acad Sci U S A. 2026 Jul 07; 123(27):e2528109123.
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