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Mark L Dell'Acqua

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations
Phone303/724-3616
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PHARM General Operations


    Collapse Research 
    Collapse research activities and funding
    R01MH123700     (DELL'ACQUA, MARK L)Apr 1, 2021 - Jan 31, 2026
    NIH
    L-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription Coupling
    Role: Principal Investigator
    R01NS110383     (BAYER, K. ULRICH ;DELL'ACQUA, MARK L ;KENNEDY, MATTHEW J)Sep 30, 2018 - Jun 30, 2024
    NIH
    Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunction
    Role: Principal Investigator
    R21NS094453     (DELL'ACQUA, MARK L)Jul 1, 2016 - Jun 30, 2019
    NIH
    Amyloid Beta Postsynaptic Signaling through AKAP-anchored Calcineurin
    Role: Principal Investigator
    R01MH102338     (DELL'ACQUA, MARK L)Dec 1, 2013 - Nov 30, 2019
    NIH
    Mechanisms of Neuronal Calcineurin-NFAT Synapse-to-Nucleus Signaling
    Role: Principal Investigator
    R01MH080291     (DELL'ACQUA, MARK L)Aug 1, 2007 - Jul 31, 2015
    NIH
    AKAP Anchored PKA and Calcineurin Regulation of Neuronal L-type Calcium Channels
    Role: Principal Investigator
    R01NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Mar 31, 2024
    NIH
    Regulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic Signaling
    Role: Principal Investigator
    R56NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Apr 30, 2015
    NIH
    Regulation of AKAP79 Postsynaptic Targeting and Signaling
    Role: Principal Investigator
    T32GM007635     (DELL'ACQUA, MARK L)Jul 1, 1978 - Jun 30, 2024
    NIH
    Predoctoral Training Grant in Pharmacology
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PMID: 38168421.
      View in: PubMed
    2. Simmons SC, Flerlage WJ, Langlois LD, Shepard RD, Bouslog C, Thomas EH, Gouty KM, Sanderson JL, Gouty S, Cox BM, Dell'Acqua ML, Nugent FS. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv. 2023 Dec 07. PMID: 38106086.
      View in: PubMed
    3. Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep; 621(7977):146-153. PMID: 37648853.
      View in: PubMed
    4. Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 07 25; 16(795):eade5892. PMID: 37490545.
      View in: PubMed
    5. Lucero EM, Freund RK, Smith A, Johnson NR, Dooling B, Sullivan E, Prikhodko O, Ahmed MM, Bennett DA, Hohman TJ, Dell'Acqua ML, Chial HJ, Potter H. Increased KIF11/kinesin-5 expression offsets Alzheimer A?-mediated toxicity and cognitive dysfunction. iScience. 2022 Nov 18; 25(11):105288. PMID: 36304124.
      View in: PubMed
    6. Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 Dec 01; 220:109271. PMID: 36162529.
      View in: PubMed
    7. Chen X, Crosby KC, Feng A, Purkey AM, Aronova MA, Winters CA, Crocker VT, Leapman RD, Reese TS, Dell'Acqua ML. Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines. Front Synaptic Neurosci. 2022; 14:1004154. PMID: 36186623.
      View in: PubMed
    8. Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022; 14:852227. PMID: 35463850.
      View in: PubMed
    9. Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR. Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity. Cell Rep. 2021 12 21; 37(12):110142. PMID: 34936876.
      View in: PubMed
    10. Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-? Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov-Dec; 8(6). PMID: 34789478.
      View in: PubMed
    11. Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ?-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors. Cell Rep. 2021 10 05; 37(1):109786. PMID: 34610314.
      View in: PubMed
    12. Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell'Acqua ML, Diamond JS, Camp CR, Perszyk RE, Yuan H, Traynelis SF. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacol Rev. 2021 10; 73(4):298-487. PMID: 34753794.
      View in: PubMed
    13. Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic ?-cells. J Biol Chem. 2021 Jan-Jun; 296:100442. PMID: 33617875.
      View in: PubMed
    14. Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 06 23; 31(12):107785. PMID: 32579917.
      View in: PubMed
    15. Purkey AM, Dell'Acqua ML. Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity. Front Synaptic Neurosci. 2020; 12:8. PMID: 32292336.
      View in: PubMed
    16. Dittmer PJ, Dell'Acqua ML, Sather WA. Synaptic crosstalk conferred by a zone of differentially regulated Ca2+ signaling in the dendritic shaft adjoining a potentiated spine. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13611-13620. PMID: 31209051.
      View in: PubMed
    17. Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756. PMID: 31091162.
      View in: PubMed
    18. Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA, Dell'Acqua ML. Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma. Cell Rep. 2019 03 26; 26(13):3537-3550.e4. PMID: 30917310.
      View in: PubMed
    19. Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019 03 19; 26(12):3284-3297.e3. PMID: 30893601.
      View in: PubMed
    20. Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 01; 95(1):20-32. PMID: 30404891.
      View in: PubMed
    21. Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 10 23; 25(4):974-987.e4. PMID: 30355502.
      View in: PubMed
    22. Tonn Eisinger KR, Woolfrey KM, Swanson SP, Schnell SA, Meitzen J, Dell'Acqua M, Mermelstein PG. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. J Biol Chem. 2018 10 12; 293(41):15901-15911. PMID: 30158247.
      View in: PubMed
    23. Dell'Acqua ML, Woolfrey KM. FRETting over postsynaptic PKC signaling. Nat Neurosci. 2018 08; 21(8):1021-1022. PMID: 30013172.
      View in: PubMed
    24. Sanderson JL, Scott JD, Dell'Acqua ML. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors. J Neurosci. 2018 03 14; 38(11):2863-2876. PMID: 29440558.
      View in: PubMed
    25. Wild AR, Dell'Acqua ML. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2018 05; 185:99-121. PMID: 29262295.
      View in: PubMed
    26. Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology. 2018 05; 43(6):1395-1404. PMID: 29317777.
      View in: PubMed
    27. Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 02 02; 293(5):1551-1567. PMID: 29196604.
      View in: PubMed
    28. Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 04 11; 19(2):321-334. PMID: 28402855.
      View in: PubMed
    29. Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 08; 93(3):646-660.e5. PMID: 28132827.
      View in: PubMed
    30. Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 08 03; 627:1-6. PMID: 27233215.
      View in: PubMed
    31. Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ?-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May; 89(5):552-9. PMID: 26957206.
      View in: PubMed
    32. Nieves-Cintr?n M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 04; 291(10):4912. PMID: 26945093.
      View in: PubMed
    33. Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca??-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 02; 89(5):1000-15. PMID: 26938443.
      View in: PubMed
    34. Nieves-Cintr?n M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40. PMID: 26724383.
      View in: PubMed
    35. Woolfrey KM, Dell'Acqua ML. Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity. J Biol Chem. 2015 Nov 27; 290(48):28604-12. PMID: 26453308.
      View in: PubMed
    36. Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015; 10(8):e0135113. PMID: 26263173.
      View in: PubMed
    37. Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015 May 29; 290(22):14107-19. PMID: 25882844.
      View in: PubMed
    38. Nieves-Cintr?n M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20; 290(12):7918-29. PMID: 25670860.
      View in: PubMed
    39. Woolfrey KM, Sanderson JL, Dell'Acqua ML. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. J Neurosci. 2015 Jan 14; 35(2):442-56. PMID: 25589740.
      View in: PubMed
    40. Murphy JG, Sanderson JL, Gorski JA, Scott JD, Catterall WA, Sather WA, Dell'Acqua ML. AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Rep. 2014 Jun 12; 7(5):1577-1588. PMID: 24835999.
      View in: PubMed
    41. Dittmer PJ, Dell'Acqua ML, Sather WA. Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A. Cell Rep. 2014 Jun 12; 7(5):1410-1416. PMID: 24835998.
      View in: PubMed
    42. Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16. PMID: 24681156.
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    43. Coultrap SJ, Freund RK, O'Leary H, Sanderson JL, Roche KW, Dell'Acqua ML, Bayer KU. Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13; 6(3):431-7. PMID: 24485660.
      View in: PubMed
    44. Nystoriak MA, Nieves-Cintr?n M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672.
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    45. Oliveria SF, Dittmer PJ, Youn DH, Dell'Acqua ML, Sather WA. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels. J Neurosci. 2012 Oct 31; 32(44):15328-37. PMID: 23115171.
      View in: PubMed
    46. Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell'Acqua ML. AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors. J Neurosci. 2012 Oct 24; 32(43):15036-52. PMID: 23100425.
      View in: PubMed
    47. Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. PMID: 22940692.
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    48. Keith DJ, Sanderson JL, Gibson ES, Woolfrey KM, Robertson HR, Olszewski K, Kang R, El-Husseini A, Dell'acqua ML. Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. J Neurosci. 2012 May 23; 32(21):7119-36. PMID: 22623657.
      View in: PubMed
    49. Li H, Pink MD, Murphy JG, Stein A, Dell'Acqua ML, Hogan PG. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol. 2012 Feb 19; 19(3):337-45. PMID: 22343722.
      View in: PubMed
    50. Brandao KE, Dell'Acqua ML, Levinson SR. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons. J Comp Neurol. 2012 Jan 01; 520(1):81-99. PMID: 21674494.
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    51. Sanderson JL, Dell'Acqua ML. AKAP signaling complexes in regulation of excitatory synaptic plasticity. Neuroscientist. 2011 Jun; 17(3):321-36. PMID: 21498812.
      View in: PubMed
    52. Lin L, Sun W, Kung F, Dell'Acqua ML, Hoffman DA. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011 Jan 26; 31(4):1323-32. PMID: 21273417.
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    53. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872.
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    54. Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 04; 285(23):17930-7. PMID: 20353941.
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    55. Clapp P, Gibson ES, Dell'acqua ML, Hoffman PL. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther. 2010 Mar; 332(3):720-9. PMID: 20008487.
      View in: PubMed
    56. Robertson HR, Gibson ES, Benke TA, Dell'Acqua ML. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. J Neurosci. 2009 Jun 17; 29(24):7929-43. PMID: 19535604.
      View in: PubMed
    57. Oliveria SF, Dell'Acqua ML, Sather WA. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron. 2007 Jul 19; 55(2):261-75. PMID: 17640527.
      View in: PubMed
    58. Horne EA, Dell'Acqua ML. Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression. J Neurosci. 2007 Mar 28; 27(13):3523-34. PMID: 17392468.
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    59. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol. 2007 Feb 12; 176(4):521-33. PMID: 17296797.
      View in: PubMed
    60. Altamura C, Dell'Acqua ML, Moessner R, Murphy DL, Lesch KP, Persico AM. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex. 2007 Jun; 17(6):1394-401. PMID: 16905592.
      View in: PubMed
    61. Smith KE, Gibson ES, Dell'Acqua ML. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci. 2006 Mar 01; 26(9):2391-402. PMID: 16510716.
      View in: PubMed
    62. Dell'Acqua ML, Smith KE, Gorski JA, Horne EA, Gibson ES, Gomez LL. Regulation of neuronal PKA signaling through AKAP targeting dynamics. Eur J Cell Biol. 2006 Jul; 85(7):627-33. PMID: 16504338.
      View in: PubMed
    63. Gorski JA, Gomez LL, Scott JD, Dell'Acqua ML. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell. 2005 Aug; 16(8):3574-90. PMID: 15930126.
      View in: PubMed
    64. Uhlik MT, Abell AN, Johnson NL, Sun W, Cuevas BD, Lobel-Rice KE, Horne EA, Dell'Acqua ML, Johnson GL. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol. 2003 Dec; 5(12):1104-10. PMID: 14634666.
      View in: PubMed
    65. Oliveria SF, Gomez LL, Dell'Acqua ML. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003 Jan 06; 160(1):101-12. PMID: 12507994.
      View in: PubMed
    66. Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD. Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem. 2002 Dec 13; 277(50):48796-802. PMID: 12354762.
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    67. Gomez LL, Alam S, Smith KE, Horne E, Dell'Acqua ML. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci. 2002 Aug 15; 22(16):7027-44. PMID: 12177200.
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    68. Scott JD, Dell'Acqua ML, Fraser ID, Tavalin SJ, Lester LB. Coordination of cAMP signaling events through PKA anchoring. Adv Pharmacol. 2000; 47:175-207. PMID: 10582087.
      View in: PubMed
    69. Dell'Acqua ML, Faux MC, Thorburn J, Thorburn A, Scott JD. Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J. 1998 Apr 15; 17(8):2246-60. PMID: 9545238.
      View in: PubMed
    70. Gao T, Yatani A, Dell'Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 1997 Jul; 19(1):185-96. PMID: 9247274.
      View in: PubMed
    71. Dell'Acqua ML, Scott JD. Protein kinase A anchoring. J Biol Chem. 1997 May 16; 272(20):12881-4. PMID: 9190362.
      View in: PubMed
    72. Hausken ZE, Dell'Acqua ML, Coghlan VM, Scott JD. Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs. J Biol Chem. 1996 Nov 15; 271(46):29016-22. PMID: 8910553.
      View in: PubMed
    73. Dell'Acqua ML, Carroll RC, Peralta EG. Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway. J Biol Chem. 1993 Mar 15; 268(8):5676-85. PMID: 8449930.
      View in: PubMed
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