 Hypoxia-Inducible Factor 1, alpha Subunit
"Hypoxia-Inducible Factor 1, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
| Descriptor ID |
D051795
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| MeSH Number(s) |
D12.776.260.103.625.750 D12.776.930.125.625.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hypoxia-Inducible Factor 1, alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Hypoxia-Inducible Factor 1, alpha Subunit".
This graph shows the total number of publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in this website by year, and whether "Hypoxia-Inducible Factor 1, alpha Subunit" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 6 | 6 | | 2005 | 1 | 0 | 1 | | 2006 | 4 | 2 | 6 | | 2007 | 4 | 6 | 10 | | 2008 | 3 | 4 | 7 | | 2009 | 5 | 1 | 6 | | 2010 | 4 | 2 | 6 | | 2011 | 4 | 5 | 9 | | 2012 | 5 | 1 | 6 | | 2013 | 7 | 6 | 13 | | 2014 | 6 | 5 | 11 | | 2015 | 2 | 3 | 5 | | 2016 | 8 | 3 | 11 | | 2017 | 3 | 0 | 3 | | 2018 | 4 | 4 | 8 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 2 | 3 | | 2021 | 5 | 2 | 7 | | 2022 | 0 | 6 | 6 | | 2023 | 0 | 4 | 4 | | 2024 | 2 | 0 | 2 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Profiles.
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Sun X, Yegambaram M, Lu Q, Garcia Flores AE, Pokharel MD, Soto J, Aggarwal S, Wang T, Fineman JR, Black SM. Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2. Redox Biol. 2025 Apr; 81:103529.
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Heidarian Y, Fasteen TD, Mungcal L, Buddika K, Mahmoudzadeh NH, Nemkov T, D'Alessandro A, Tennessen JM. Hypoxia-inducible factor 1a is required to establish the larval glycolytic program in Drosophila melanogaster. Mol Metab. 2025 Mar; 93:102106.
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Kadyrov FF, Koenig AL, Amrute JM, Dun H, Li W, Weinheimer CJ, Nigro JM, Kovacs A, Bredemeyer AL, Yang S, Das S, Penna VR, Parvathaneni A, Lai L, Hartmann N, Kopecky BJ, Kreisel D, Lavine KJ. Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury. Nat Cardiovasc Res. 2024 Nov; 3(11):1337-1355.
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Ryan S, Crowe L, Almeida Cruz SN, Galbraith MD, O'Brien C, Hammer JA, Bergin R, Kellett SK, Markey GE, Benson TM, Fagan O, Espinosa JM, Conlon N, Donohoe CL, McKiernan S, Hogan AE, McNamee EN, Furuta GT, Menard-Katcher C, Masterson JC. Metabolic dysfunction mediated by HIF-1a contributes to epithelial differentiation defects in eosinophilic esophagitis. J Allergy Clin Immunol. 2024 Dec; 154(6):1472-1488.
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Ornelas A, Welch N, Countess JA, Zhou L, Wang RX, Dowdell AS, Colgan SP. Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers. Gut Microbes. 2023 12; 15(2):2267706.
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Zhang J, Sharma D, Dinabandhu A, Sanchez J, Applewhite B, Jee K, Deshpande M, Flores-Bellver M, Hu MW, Guo C, Salman S, Hwang Y, Anders NM, Rudek MA, Qian J, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice. J Clin Invest. 2023 07 03; 133(13).
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Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 07; 69(1):73-86.
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Guo C, Deshpande M, Niu Y, Kachwala I, Flores-Bellver M, Megarity H, Nuse T, Babapoor-Farrokhran S, Ramada M, Sanchez J, Inamdar N, Johnson TV, Canto-Soler MV, Montaner S, Sodhi A. HIF-1a accumulation in response to transient hypoglycemia may worsen diabetic eye disease. Cell Rep. 2023 01 31; 42(1):111976.
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Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 12 22; 7(24).
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Liao Y, Luo Z, Lin Y, Chen H, Chen T, Xu L, Orgurek S, Berry K, Dzieciatkowska M, Reisz JA, D'Alessandro A, Zhou W, Lu QR. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death Dis. 2022 11 09; 13(11):943.
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