 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 15 | 20 | 35 | | 1997 | 17 | 29 | 46 | | 1998 | 20 | 30 | 50 | | 1999 | 16 | 23 | 39 | | 2000 | 13 | 28 | 41 | | 2001 | 18 | 34 | 52 | | 2002 | 17 | 46 | 63 | | 2003 | 23 | 56 | 79 | | 2004 | 49 | 73 | 122 | | 2005 | 32 | 71 | 103 | | 2006 | 45 | 79 | 124 | | 2007 | 37 | 74 | 111 | | 2008 | 34 | 93 | 127 | | 2009 | 46 | 82 | 128 | | 2010 | 55 | 95 | 150 | | 2011 | 54 | 116 | 170 | | 2012 | 49 | 143 | 192 | | 2013 | 62 | 145 | 207 | | 2014 | 62 | 158 | 220 | | 2015 | 58 | 145 | 203 | | 2016 | 40 | 114 | 154 | | 2017 | 47 | 123 | 170 | | 2018 | 34 | 138 | 172 | | 2019 | 43 | 134 | 177 | | 2020 | 29 | 118 | 147 | | 2021 | 25 | 90 | 115 | | 2022 | 8 | 45 | 53 | | 2023 | 5 | 33 | 38 | | 2024 | 36 | 58 | 94 | | 2025 | 26 | 90 | 116 | | 2026 | 22 | 67 | 89 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Kantaputra P, Guven Y, Bunpiem N, Cochran K, Qiu T, Brooks EC, Kangvonkit P, Arayasantiwong S, Ngamphiw C, Tongsima S, Sompoprungroat P, Sengtae N, Chintakanon K, Ngaohiranpat S, Leetanakul C, Arold ST, Kalayci T, Kawasaki K, Ohazama A, Brugmann SA, Tucker AS. C2CD3 links tooth patterning to evolutionary tooth loss in birds and dental anomalies across vertebrates. Proc Natl Acad Sci U S A. 2026 Nov 03; 123(44):e2603057123.
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Hirose K, Chen X, Kalyanaraman C, Waddingham MT, Nakamura M, Zhang F, Chen C, Yao S, Chang S, Yu H, Wang J, Barca E, Nakano H, Hsu A, Khyeam S, Gonzalez Ortega S, Tajima K, Yoneshiro T, Zhang H, Padmanabhan A, Kajimura S, Haldar S, Nakano A, Murai M, Fujihara Y, Otsu K, Quinzii CM, Jacobson MP, Hu G, Pearson JT, Huang GN. A muscle-enriched mitochondrial protein regulates postnatal heart growth through mitonuclear ubiquinone-PPAR signaling. Proc Natl Acad Sci U S A. 2026 Oct 20; 123(42):e2619615123.
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Donson AM, Griesinger AM, Chapman RJ, Grundy RG, Kilday JP, Ramaswamy V, Levy JMM, Kaufman ML, Amani V, Sundheimer JK, Pajtler KW, Foreman NK, Ritzmann TA. Chromosome 6q mediated loss of LATS1 tumour suppression as a targetable mechanism of ultra-high-risk posterior fossa A ependymoma. Acta Neuropathol. 2026 Oct 13; 152(1).
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Li L, Liu S, Lei Z, Macaluso J, Guo S, MacPhail K, Mroz MM, Restrepo CI, Yang IY, Maier LA. Immune regulation by CD55 in chronic beryllium disease. Am J Respir Cell Mol Biol. 2026 Oct 01; 74(10):1431-1439.
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Li W, Grieshober L, Gertz J, Ivich A, Doherty JA, Greene CS, Hicks SC. Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics. Genome Res. 2026 Oct 01; 36(10):2011-2026.
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Guo K, Dillon SM, Meneses EC, Barrett BS, Norman A, Mickens KL, Morrison JH, Dittmer U, Sutter K, Poeschla EM, Kechris K, Wilson CC, Santiago ML. Interferome profiling in the blood links IFNa5-Mucin-1 axis to HIV-1 pathogenesis. J Virol. 2026 Oct 20; 100(10):e0108926.
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McColl ER, Kumar D, Jones BR, Marks N, Diveley E, Karvas R, Theunissen TW, Kelly JC, Mysorekar IU. Placental trophoblasts exhibit iron dysregulation and ferroptosis signaling associated with SARS-CoV-2 restriction. Cell Rep. 2026 Oct 27; 45(10):118040.
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Li J, Karoor V, Frump AL, Zhao H, Liang S, Woodcock CC, Petrache I, Dai Z, Lahm T. Sexually Dimorphic Role of Estrogen Receptor a in Preserving Right Ventricular Endothelial Integrity. Arterioscler Thromb Vasc Biol. 2026 Nov; 46(11):e325390.
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Sasse SK, Kadiyala V, Chen M, Weaver MR, McCain SC, Gupta A, Panettieri RA, Gerber AN. Multiomics analysis of glucocorticoid receptor cross talk with type I and type II inflammatory signaling in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2026 Nov 01; 331(5):L455-L473.
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Nadorp B, Lasry A, Loghavi S, Patel R, Mansour H, Rovatti PE, Kelly BJ, Walker CJ, Buss J, Boateng I, Al-Santli W, Ciantra Z, Austin R, Desai H, Abaza H, Procell L, Patel T, Kaffenberger B, Wijeratne S, Guillamot M, Velegraki M, Chiriboga LA, Li Z, Pollyea DA, McMahon CM, Shanaah A, Byrd JC, Esteller M, Papapetrou EP, Tsirigos A, Mims AS, Mardis ER, Aifantis I, Eisfeld AK. RAS Pathway Activation and Microenvironmental Adaptation as Hallmarks of Myeloid Sarcoma. Blood Cancer Discov. 2026 Sep 03; 7(5):759-773.
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