Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
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MeSH Number(s) |
G02.111.820 G04.835
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Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 17 | 13 | 30 | 1995 | 19 | 25 | 44 | 1996 | 15 | 24 | 39 | 1997 | 21 | 31 | 52 | 1998 | 21 | 29 | 50 | 1999 | 21 | 30 | 51 | 2000 | 18 | 36 | 54 | 2001 | 19 | 28 | 47 | 2002 | 13 | 33 | 46 | 2003 | 28 | 56 | 84 | 2004 | 54 | 77 | 131 | 2005 | 35 | 80 | 115 | 2006 | 44 | 85 | 129 | 2007 | 36 | 76 | 112 | 2008 | 35 | 89 | 124 | 2009 | 48 | 88 | 136 | 2010 | 58 | 93 | 151 | 2011 | 51 | 109 | 160 | 2012 | 45 | 141 | 186 | 2013 | 57 | 147 | 204 | 2014 | 61 | 157 | 218 | 2015 | 54 | 133 | 187 | 2016 | 35 | 116 | 151 | 2017 | 43 | 109 | 152 | 2018 | 32 | 127 | 159 | 2019 | 42 | 123 | 165 | 2020 | 25 | 101 | 126 | 2021 | 24 | 74 | 98 | 2022 | 5 | 40 | 45 | 2023 | 5 | 30 | 35 | 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Obara CJ, Nixon-Abell J, Moore AS, Riccio F, Hoffman DP, Shtengel G, Xu CS, Schaefer K, Pasolli HA, Masson JB, Hess HF, Calderon CP, Blackstone C, Lippincott-Schwartz J. Motion of VAPB molecules reveals ER-mitochondria contact site subdomains. Nature. 2024 Feb; 626(7997):169-176.
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Sottnik JL, Shackleford MT, Robinson SK, Villagomez FR, Bahnassy S, Oesterreich S, Hu J, Madak-Erdogan Z, Riggins RB, Corr BR, Cook LS, Trevi?o LS, Bitler BG, Sikora MJ. WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers. Cancer Res Commun. 2024 Jan 17; 4(1):134-151.
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Kanai SM, Clouthier DE. Endothelin signaling in development. Development. 2023 Dec 15; 150(24).
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Robinson CJ, Thiagarajan L, Maynard R, Aruketty M, Herrera J, Dingle L, Reid A, Wong J, Cao H, Dooley J, Liston A, M?llhaupt D, Hiebert P, Hiebert H, Kurinna S. Release of miR-29 Target Laminin C2 Improves Skin Repair. Am J Pathol. 2024 Feb; 194(2):195-208.
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Ruebel ML, Borengasser SJ, Zhong Y, Kang P, Faske J, Shankar K. Maternal Exercise Prior to and during Gestation Induces Sex-Specific Alterations in the Mouse Placenta. Int J Mol Sci. 2023 Nov 17; 24(22).
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Shull LC, Artinger KB. Epigenetic regulation of craniofacial development and disease. Birth Defects Res. 2024 Jan; 116(1):e2271.
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Kramer AC, Jansson T, Bale TL, Powell TL. Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism. Development. 2023 10 15; 150(20).
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Chalkley ML, Mersfelder RB, Sundberg M, Armstrong LC, Sahin M, Ihrie RA, Ess KC. Non-canonical functions of a mutant TSC2 protein in mitotic division. PLoS One. 2023; 18(10):e0292086.
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Zhang H, Zhu Y, Suehiro Y, Mitani S, Xue D. AMPK-FOXO-IP3R signaling pathway mediates neurological and developmental defects caused by mitochondrial DNA mutations. Proc Natl Acad Sci U S A. 2023 09 05; 120(36):e2302490120.
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Li J, Malouf C, Miles LA, Willis MB, Pietras EM, King KY. Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells. Exp Hematol. 2023 11; 127:8-13.
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