 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 16 | 21 | 37 | | 1996 | 15 | 22 | 37 | | 1997 | 16 | 29 | 45 | | 1998 | 21 | 29 | 50 | | 1999 | 16 | 25 | 41 | | 2000 | 13 | 32 | 45 | | 2001 | 21 | 37 | 58 | | 2002 | 17 | 50 | 67 | | 2003 | 25 | 57 | 82 | | 2004 | 49 | 71 | 120 | | 2005 | 32 | 76 | 108 | | 2006 | 47 | 82 | 129 | | 2007 | 33 | 70 | 103 | | 2008 | 36 | 91 | 127 | | 2009 | 46 | 85 | 131 | | 2010 | 54 | 92 | 146 | | 2011 | 50 | 115 | 165 | | 2012 | 47 | 142 | 189 | | 2013 | 59 | 144 | 203 | | 2014 | 62 | 159 | 221 | | 2015 | 56 | 143 | 199 | | 2016 | 37 | 114 | 151 | | 2017 | 47 | 117 | 164 | | 2018 | 34 | 139 | 173 | | 2019 | 43 | 134 | 177 | | 2020 | 30 | 112 | 142 | | 2021 | 26 | 86 | 112 | | 2022 | 8 | 42 | 50 | | 2023 | 5 | 33 | 38 | | 2024 | 35 | 57 | 92 | | 2025 | 17 | 50 | 67 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Nishida-Aoki N, Zhu S, Chan M, Kang Y, Fujita M, Jiang X, McCabe M, Vaz JM, Davidson NE, Ghajar CM, Hansen K, Welm AL, Pillarisetty VG, Gujral TS. Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts. Cell Rep Med. 2025 Oct 21; 6(10):102357.
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Mulkearns-Hubert EE, Hajdari N, Hong ES, Jacobs AP, Gaboriau A, Giltner S, Tannish G, Kay KE, Wang SZ, LaViolette PS, Silver DJ, Hubert CG, Dhawan A, Lathia JD. Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis. Cell Rep. 2025 Sep 23; 44(9):116303.
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Scharf G, Davidson CR, Ustiyan V, Falkenberg LG, Adavalli A, Meeker JD, Morgan H, Ostmann AJ, Hudock KM, Brewington JJ, Clancy JP, Kramer EL. TGF-ß induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. Am J Physiol Lung Cell Mol Physiol. 2025 Oct 01; 329(4):L470-L479.
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Nangia V, Ashraf H, Marikar N, Passanisi VJ, Ill CR, Spencer SL. MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells. Sci Signal. 2025 Sep 02; 18(902):eadw3231.
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Albert GK, Cao P, Davila E. Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity. Front Immunol. 2025; 16:1617773.
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Liu H, Yu L, Majerciak V, Meyer TJ, Yi M, Johnson PF, Cam M, Lowy DR, Zheng ZM. The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells. Elife. 2025 Aug 29; 13.
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Julian CG. Beyond blood flow: the multifaceted role of AMPK in regulating fetal growth at high altitudes. Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21; 380(1933):20240173.
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de Castro LL, Gomes da Rosa B, Peixoto-Rodrigues MC, Revoredo Vicentino AR, Fraga-Junior VdS, Cascabulho CM, Diniz LP, Benjamim CF, Bracko O, Scharfstein J, Adesse D. Toxoplasma gondii impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation. Microbiol Spectr. 2025 Oct 07; 13(10):e0107425.
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Zhou X, Moreira S, Restelli C, Wang H, Jahangiri S, Aryal S, Tsao E, Zhang P, Niu M, Kumar H, Balde Z, Vujovic A, Liu L, Wong N, Arruda A, Minden MD, Zhou Y, Ravi B, Qi J, Li C, Hope KJ, Lu R. Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models. Sci Transl Med. 2025 Aug 06; 17(810):eadn5400.
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Singh N, Ali M, Biswal P, Jaiswal A, Mishra D, Agarwal R, Zaidi R, Singh RP. Inhibition of Growth and Survival of Head and Neck Cancer Cells by Silibinin Involves the Down-Regulation of Erk1/2, AKT and STAT3 Signaling. Mol Carcinog. 2025 Oct; 64(10):1735-1750.
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