 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 15 | 22 | 37 | | 1997 | 17 | 29 | 46 | | 1998 | 20 | 30 | 50 | | 1999 | 16 | 23 | 39 | | 2000 | 13 | 28 | 41 | | 2001 | 19 | 34 | 53 | | 2002 | 17 | 45 | 62 | | 2003 | 24 | 57 | 81 | | 2004 | 49 | 73 | 122 | | 2005 | 32 | 70 | 102 | | 2006 | 47 | 79 | 126 | | 2007 | 37 | 73 | 110 | | 2008 | 34 | 93 | 127 | | 2009 | 46 | 82 | 128 | | 2010 | 55 | 97 | 152 | | 2011 | 55 | 116 | 171 | | 2012 | 48 | 143 | 191 | | 2013 | 61 | 148 | 209 | | 2014 | 62 | 158 | 220 | | 2015 | 58 | 143 | 201 | | 2016 | 38 | 116 | 154 | | 2017 | 47 | 121 | 168 | | 2018 | 34 | 135 | 169 | | 2019 | 43 | 135 | 178 | | 2020 | 30 | 116 | 146 | | 2021 | 25 | 89 | 114 | | 2022 | 8 | 45 | 53 | | 2023 | 5 | 33 | 38 | | 2024 | 35 | 59 | 94 | | 2025 | 26 | 87 | 113 | | 2026 | 16 | 42 | 58 |
To return to the timeline, click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Ziogas IA, Conover KR, Dobrinskikh E, Al-Juboori SI, Gromer KD, Malladi P, Wright CJ, Sokol RJ, Andrews T, Taylor SA. Spatial transcriptomics supports a role for SOX4-driven signaling throughout the disease course of biliary atresia. Hepatol Commun. 2026 Aug 01; 10(8).
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Kolora LD, Melendez-Suchi C, Butler V, Han L, Almeida M, Shankar K, Adams DJ, Iyer S. IRE1 signaling in osteoprogenitors augments ß-catenin activity and physiologic bone accrual. J Bone Miner Res. 2026 Jul 24; 41(8):890-902.
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Gong S, Adler J, Zhu Y, Szeto C, Lin L, Rauffenbart C, Torres-Herraez A, Asher WB, Javitch JA, Ford CP. Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning. Sci Adv. 2026 Jul 24; 12(30):eaee6579.
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Lin HK, Blake DA, Freeman R, Chen Y, Kim J, Johnson AM, Wells K, Mudigonda A, Liu W, Yadav P, Zeng F, Muhuri A, Min K, Sarkar S, Wang Y, Goyal S, Roberts RC, Christensen E, Ward AB, Heller B, Chun P, Dougan J, Porter CC, Barwick BG, Paulos CM, Yang L, Patgiri A, Thomas SN, Waller EK, Rafiq S. Modulating the VIP-VIPR pathway reprograms CAR T cells for superior antitumor efficacy in preclinical cancer models. Sci Transl Med. 2026 Jul 22; 18(859):eadt9565.
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Diba P, Levasseur PR, Newton SD, Koh KMS, Arneson-Wissink PC, Zhu X, Pham P, Mendez H, Whitcomb L, Sattler A, Woodward WR, Habecker BA, Marks DL, Grossberg AJ. Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart. J Physiol. 2026 Aug; 604(15):6281-6301.
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Hoff FW, Zeidner JF, Torlapati G, Nicolet D, Mrózek K, Huang Y, Li A, Welkie RL, Swords RT, Traer E, Stein EM, Lin TL, Baer MR, Duong VH, Blum WG, Arellano ML, Stock W, Odenike O, Olin RL, Smith CC, Schiller GJ, Curran EK, Chan O, McMahon C, Hochman M, Sahasrabudhe K, Foucar C, Gonzalez-Lugo J, Knick Ragon B, Handa SV, Heerema NA, Chen T, Martycz M, Stefanos M, Marcus SG, Rosenberg L, Druker BJ, Levine RL, Burd A, Yocum AO, Borate UM, Mims AS, Eisfeld AK, Byrd JC, Madanat YF. Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA. Am J Hematol. 2026 Sep; 101(9):2246-2257.
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McAllister RA, Stiegler AL, Chari K, Chari M, Bhattacharyya M, Gupta K. Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation. Proc Natl Acad Sci U S A. 2026 Jul 07; 123(27):e2528109123.
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Janssen WJ, Lapinig M, Wynn E, Aguilar M, Mould KJ, Hume PS, McClendon JD, Lee FFY, Moore CM, Alper S. Alternative splicing of toll-like receptor pathway mRNAs in lung immune cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2026 Aug 01; 331(2):L155-L164.
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A Turner J, D'Antonio M, Montane HN, MacBeth M, Katsnelson E, Robinson WA, Tobin RP, Couts KL, Markovic SN, Torres RM. Targeting liver metastases in uveal melanoma: ATX-LPA mediated immunosuppression and novel therapeutic approaches. Front Immunol. 2026; 17:1829486.
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McDougle DR, Moon JJ, Fox DA. Myeloid-Derived Suppressor Cells in Inflammatory Arthritis. Int J Mol Sci. 2026 Jun 14; 27(12).
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