 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 15 | 22 | 37 | | 1997 | 17 | 29 | 46 | | 1998 | 20 | 29 | 49 | | 1999 | 16 | 23 | 39 | | 2000 | 14 | 28 | 42 | | 2001 | 20 | 34 | 54 | | 2002 | 16 | 48 | 64 | | 2003 | 24 | 56 | 80 | | 2004 | 49 | 73 | 122 | | 2005 | 32 | 71 | 103 | | 2006 | 46 | 81 | 127 | | 2007 | 37 | 73 | 110 | | 2008 | 34 | 95 | 129 | | 2009 | 46 | 82 | 128 | | 2010 | 53 | 97 | 150 | | 2011 | 55 | 118 | 173 | | 2012 | 50 | 144 | 194 | | 2013 | 63 | 150 | 213 | | 2014 | 63 | 160 | 223 | | 2015 | 58 | 145 | 203 | | 2016 | 38 | 117 | 155 | | 2017 | 47 | 122 | 169 | | 2018 | 34 | 137 | 171 | | 2019 | 43 | 138 | 181 | | 2020 | 30 | 118 | 148 | | 2021 | 25 | 90 | 115 | | 2022 | 8 | 46 | 54 | | 2023 | 5 | 33 | 38 | | 2024 | 35 | 59 | 94 | | 2025 | 26 | 87 | 113 | | 2026 | 12 | 32 | 44 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Shaw SC, Jamil TL, Heslop G, Fleck JT, Johnson W, Lorenz BP, Drigot Z, Harris JK, Gitomer SA, Clark SE. Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection. Cell Rep Med. 2026 Jun 16; 7(6):102846.
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Liu Y, Carter JM, Ma Y, Deshmukh SK, Sledge GW, Balko JM, Kachergus JM, Shi J, Gregory M, Gong J, Joensuu H, Perez EA, Stover D, Carey L, Sikov WM, Leon-Ferre R, Knutson KL, Boughey JC, Ingle JN, Kalari KR, Couch FJ, Asmann YW, Goetz MP, Thompson EA, Chumsri S. Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. J Immunother Cancer. 2026 Jun 03; 14(6).
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Magno JC, Guo J, Hall SC, Liu J, Albert GK, Carter JD, Davalos AS, Cao P, Bangar A, Drigot Z, Hudson H, Geluck T, Nevala WK, Markovic SN, Wilky BA, Davila E. Engineering T Cells with a Tumor-Reactive Chimeric T-cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses. Cancer Res. 2026 Jun 01; 86(11):2688-2702.
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Balolia A, Arena KA, Shahood A, Russom H, Tran LN, Winkler CC, O'Rourke R, Vue TY, Sagerström CG, Appel BH, Franco SJ. Ascl1 promotes OPC specification across species and central nervous system regions and its gliogenic function is regulated by phosphorylation. Dev Biol. 2026 Aug; 536:184-201.
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Malyshkina A, Solar M, Balasubramaniyan N, Zheng L, McCulley DJ, Morro M, Seymour C, Sajti E, Orlicky DJ, Sosa A, Smith BJ, Wright CJ. TLR9-mediated innate immune signaling contributes to acetaminophen-induced injury in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2026 Jul 01; 331(1):L16-L33.
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Owen MC, Li DY, Shin H, Gu W, Parvathaneni A, Kadyrov FF, Wang X, Sticco-Ivins M, Bonnici G, Nelson SL, Dun H, Hyacinth S, Giangrasso SC, Chou C, Lin CY, Cain MT, Pedroza A, Dalal A, Sallam K, Boyd J, Woo J, Amrute JM, Cheng P, Lavine KJ, Kopecky BJ. Single-cell and spatial transcriptomics identify immune-stromal interactions in cardiac allograft vasculopathy. Nat Cardiovasc Res. 2026 May; 5(5):439-455.
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Park C, Yang Z, Nashef A, Gim J, Bahn S, Kim GH, Zhang K, Cathala L, Hong S, Im Y, Lee SH, Lee K, Kim MS, Arnold DB, Lee KJ, Christie JM, Kim JS. Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits. Nat Neurosci. 2026 Jun; 29(6):1425-1438.
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Francis EC, Boyle KE, Gyllenhammer LE, Dabelea D, Jansson T, Perng W. Placental insulin-mTOR and stress-inflammatory signaling patterns are associated with childhood adiposity. BMC Med. 2026 May 08; 24(1).
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Yang Y, Atkins CL, Fan Y, Hou L, Zhao J, Gao J, Wen Y, Moreno NF, Huang X, Bishehsari F, Czopik AK, Colgan SP, Purnak T, Summa KC, Cong Y, Jacobsen EA, Ju C. Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis. Proc Natl Acad Sci U S A. 2026 May 12; 123(19):e2525334123.
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Yu B, Suehiro Y, Johnson BJ, Lee ES, Li D, Huang Y, Johnson J, Ou G, DeGregori J, Mitani S, Xue D. Cathepsin B protease mediates high population density-induced mutagenesis to drive genome evolution and competitive growth. Nat Commun. 2026 May 04; 17(1).
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