 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 15 | 20 | 35 | | 1997 | 17 | 29 | 46 | | 1998 | 20 | 30 | 50 | | 1999 | 16 | 23 | 39 | | 2000 | 13 | 28 | 41 | | 2001 | 18 | 34 | 52 | | 2002 | 17 | 45 | 62 | | 2003 | 23 | 56 | 79 | | 2004 | 49 | 73 | 122 | | 2005 | 32 | 71 | 103 | | 2006 | 45 | 79 | 124 | | 2007 | 37 | 74 | 111 | | 2008 | 34 | 93 | 127 | | 2009 | 46 | 82 | 128 | | 2010 | 55 | 95 | 150 | | 2011 | 54 | 116 | 170 | | 2012 | 49 | 143 | 192 | | 2013 | 62 | 145 | 207 | | 2014 | 61 | 157 | 218 | | 2015 | 58 | 145 | 203 | | 2016 | 40 | 114 | 154 | | 2017 | 47 | 121 | 168 | | 2018 | 34 | 138 | 172 | | 2019 | 43 | 134 | 177 | | 2020 | 29 | 118 | 147 | | 2021 | 25 | 89 | 114 | | 2022 | 8 | 45 | 53 | | 2023 | 5 | 33 | 38 | | 2024 | 36 | 58 | 94 | | 2025 | 26 | 88 | 114 | | 2026 | 18 | 53 | 71 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Sharma JR, Singh V, Kandhari K, Agraval H. From smoke to stemness: Mechanisms of cancer stem cell induction by cigarette smoke. Biochim Biophys Acta Rev Cancer. 2026 Oct; 1881(5):189700.
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Follmer ML, Payne SL, George LF, Calderon J, Ozekin Y, Bates EA. Botulinum toxin dysregulates calcium activity and prevents Dpp/BMP secretion from epithelial cells in the developing fly wing. Dev Biol. 2026 Nov; 539:149-161.
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Safford HC, Geisler HC, Thatte AS, Liao KC, Poirier A, Padilla M, Yamagata HM, Agrawal A, Murray AM, Hamilton AG, Swingle KL, Fitzgerald E, Chalom O, Wan Y, Mitchell MJ. Enhancing Lipid Nanoparticle-Mediated Circular RNA and mRNA Expression in the Placenta through Inhibition of IFNAR-JAK-STAT Signaling. Nano Lett. 2026 08 26; 26(33):10980-10991.
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da Silva RA, Parween S, Howell A, Hayden S, Roberson PA, Peji A, Gil CD, Vergara MN. The peptide Ac2-26 preserves mitochondrial function and neuronal survival in human retinal cells and organoids under hyperglycemic and inflammatory stress. Biomed Pharmacother. 2026 Oct; 203:119849.
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Maeda K, Campbell PL, Wu Q, Tsou PS, Cooney LA, Mao-Draayer Y, Fox DA, Gurrea-Rubio M. Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation. Front Immunol. 2026; 17:1918840.
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Rivera TC, Schweitzer KS, Cornell C, Nall J, Egersdorf N, Moeder C, Cooney RA, Vladar EK, Groshong SD, Downey GP, Bridges JP, Bowen R, Chu HW, Petrache I. E-cigarette exposure triggers distal lung cell injury, persistent lung stress response, and antiviral immune suppression. JCI Insight. 2026 Sep 22; 11(18).
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Clements CM, Roney MSI, Shellman YG. SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics. Int J Mol Sci. 2026 Aug 06; 27(15).
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Contreras-Zárate MJ, Jaramillo-Gómez JA, Marquez-Ortiz RA, Pham TC, Koliavas SN, Ormond DR, Navarro AC, Nemenoff RA, Camidge DR, Cittelly DM. Targeting Wild-type NTRK in NTRK Fusion-Negative Lung Cancer Decreases Brain Metastases. Cancer Res Commun. 2026 Aug 01; 6(8):1850-1861.
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Wilhelm FM, Pluhackova K, Janetzko J, Masureel M, Marsh E, Hudspeth J, Gaßner W, Schertler GFX, Kobilka BK, Müller DJ. Factors modulating the assembly of human ß2-adrenergic receptor-ß-arrestin complexes. Nat Struct Mol Biol. 2026 Aug; 33(8):1158-1170.
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Ziogas IA, Conover KR, Dobrinskikh E, Al-Juboori SI, Gromer KD, Malladi P, Wright CJ, Sokol RJ, Andrews T, Taylor SA. Spatial transcriptomics supports a role for SOX4-driven signaling throughout the disease course of biliary atresia. Hepatol Commun. 2026 Aug 01; 10(8).
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