 Transcriptional Activation
"Transcriptional Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
| Descriptor ID |
D015533
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| MeSH Number(s) |
G05.308.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Transcriptional Activation".
Below are MeSH descriptors whose meaning is more specific than "Transcriptional Activation".
This graph shows the total number of publications written about "Transcriptional Activation" by people in this website by year, and whether "Transcriptional Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 3 | 4 | | 1996 | 1 | 2 | 3 | | 1997 | 3 | 5 | 8 | | 1998 | 3 | 2 | 5 | | 1999 | 2 | 5 | 7 | | 2000 | 0 | 6 | 6 | | 2001 | 2 | 5 | 7 | | 2002 | 3 | 6 | 9 | | 2003 | 4 | 9 | 13 | | 2004 | 4 | 9 | 13 | | 2005 | 2 | 9 | 11 | | 2006 | 4 | 11 | 15 | | 2007 | 2 | 6 | 8 | | 2008 | 3 | 11 | 14 | | 2009 | 3 | 12 | 15 | | 2010 | 3 | 8 | 11 | | 2011 | 2 | 5 | 7 | | 2012 | 3 | 6 | 9 | | 2013 | 5 | 15 | 20 | | 2014 | 3 | 3 | 6 | | 2015 | 2 | 5 | 7 | | 2016 | 2 | 6 | 8 | | 2017 | 4 | 7 | 11 | | 2018 | 9 | 5 | 14 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 5 | 5 | | 2022 | 2 | 1 | 3 | | 2023 | 0 | 4 | 4 | | 2024 | 2 | 3 | 5 | | 2025 | 3 | 2 | 5 |
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Below are the most recent publications written about "Transcriptional Activation" by people in Profiles.
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Palacio M, Taatjes DJ. Real-time visualization of reconstituted transcription reveals RNAPII activation mechanisms at single promoters. Cell Rep. 2025 Sep 23; 44(9):116251.
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Becht DC, Biswas S, Xu C, Xuan H, Khalil M, Cai L, Musselman CA, Liu X, Affar EB, Shi X, Wang GG, Kutateladze TG. Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300. Biochem J. 2025 Jul 02; 482(13):955-968.
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Nagel M, Taatjes DJ. Regulation of RNA polymerase II transcription through re-initiation and bursting. Mol Cell. 2025 May 15; 85(10):1907-1919.
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Itkin T, Houghton S, Schreiner R, Lin Y, Badwe CR, Voisin V, Murison A, Seyedhassantehrani N, Kaufmann KB, Garcia-Prat L, Booth GT, Geng F, Liu Y, Gomez-Salinero JM, Shieh JH, Redmond D, Xiang JZ, Josefowicz SZ, Trapnell C, Pietras EM, Spencer JA, Levine R, Xiao W, Zangi L, Hadland B, Dick JE, Xie SZ, Rafii S. Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing. Nat Immunol. 2025 Mar; 26(3):378-390.
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Hartman GD, Muniyandi A, Sishtla K, Kpenu EK, Miller WP, Kaplan BA, Kim LA, Liu S, Wan J, Qi X, Boulton ME, Kelley MR, Corson TW. Ref-1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF-1a. FASEB J. 2025 Feb 15; 39(3):e70348.
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Zhao L, Nakajima R, Zhou Y, Shirasawa M, Fikriyanti M, Kamiya Y, Toh H, Komori H, Iwanaga R, Bradford AP, Nishitani H, Kurayoshi K, Araki K, Ohtani K. The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2. Biomolecules. 2024 Oct 25; 14(11).
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Shirasawa M, Nakajima R, Zhou Y, Zhao L, Fikriyanti M, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1. Genes (Basel). 2024 Aug 15; 15(8).
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Hyder U, Challa A, Thornton M, Nandu T, Kraus WL, D'Orso I. KAP1 negatively regulates RNA polymerase II elongation kinetics to activate signal-induced transcription. Nat Commun. 2024 Jul 12; 15(1):5859.
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Hayati RF, Nakajima R, Zhou Y, Shirasawa M, Zhao L, Fikriyanti M, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1. Genes (Basel). 2024 May 27; 15(6).
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Randolph K, Hyder U, Challa A, Perez E, D'Orso I. Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation. Viruses. 2024 01 13; 16(1).
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