 Dizocilpine Maleate
"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
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| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 1 | 3 | | 2016 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 06; 135:343-354.
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Novick AM, Mears M, Forster GL, Lei Y, Tejani-Butt SM, Watt MJ. Adolescent social defeat alters N-methyl-D-aspartic acid receptor expression and impairs fear learning in adulthood. Behav Brain Res. 2016 May 01; 304:51-9.
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Timic Stamenic T, Joksimovic S, Biawat P, Stankovic T, Markovic B, Cook JM, Savic MM. Negative modulation of a5 GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. J Psychopharmacol. 2015 Sep; 29(9):1013-24.
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Allen RM, Mandt BH, Jaskunas J, Hackley A, Shickedanz A, Bergkamp D. Continuous exposure to dizocilpine facilitates the acquisition and escalation of cocaine consumption in male Sprague-Dawley rats. Drug Alcohol Depend. 2015 Feb 01; 147:137-43.
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Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek JC, Strnad F, Traystman RJ, Herson PS. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. Neuroscience. 2015 Jan 22; 284:555-565.
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Jones KS, Corbin JG, Huntsman MM. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia. PLoS One. 2014; 9(10):e109303.
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Allen RM. Continuous exposure to dizocilpine facilitates escalation of cocaine consumption in male Sprague-Dawley rats. Drug Alcohol Depend. 2014 Jan 01; 134:38-43.
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Nguyen CD, Costa AC, Cios KJ, Gardiner KJ. Machine learning methods predict locomotor response to MK-801 in mouse models of down syndrome. J Neurogenet. 2011 Mar; 25(1-2):40-51.
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Ford CP, Phillips PE, Williams JT. The time course of dopamine transmission in the ventral tegmental area. J Neurosci. 2009 Oct 21; 29(42):13344-52.
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Sanderson JL, Donald Partridge L, Valenzuela CF. Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder. Neuropharmacology. 2009 Feb; 56(2):541-55.
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