Mice, Knockout
"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
|
MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1995 | 0 | 2 | 2 | 1996 | 0 | 12 | 12 | 1997 | 0 | 13 | 13 | 1998 | 1 | 18 | 19 | 1999 | 1 | 15 | 16 | 2000 | 0 | 30 | 30 | 2001 | 0 | 40 | 40 | 2002 | 0 | 41 | 41 | 2003 | 0 | 47 | 47 | 2004 | 1 | 60 | 61 | 2005 | 2 | 69 | 71 | 2006 | 0 | 72 | 72 | 2007 | 0 | 71 | 71 | 2008 | 0 | 77 | 77 | 2009 | 2 | 92 | 94 | 2010 | 0 | 95 | 95 | 2011 | 0 | 97 | 97 | 2012 | 0 | 99 | 99 | 2013 | 0 | 121 | 121 | 2014 | 0 | 105 | 105 | 2015 | 0 | 100 | 100 | 2016 | 0 | 90 | 90 | 2017 | 0 | 81 | 81 | 2018 | 0 | 92 | 92 | 2019 | 0 | 77 | 77 | 2020 | 0 | 96 | 96 | 2021 | 0 | 75 | 75 | 2022 | 0 | 24 | 24 | 2023 | 0 | 19 | 19 | 2024 | 18 | 26 | 44 | 2025 | 2 | 21 | 23 |
To return to the timeline, click here.
Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
-
Wei Z, Boateng NKK, Schmitt LR, Cline H, Fernandes Fonseca MT, Newberry A, Taylor A, Adelmeijer J, Poole LG, Stravitz RT, Lee WM, Lisman T, Hansen KC, Luyendyk JP. Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver. Blood. 2025 May 22; 145(21):2507-2517.
-
Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES. Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia. Am J Physiol Lung Cell Mol Physiol. 2025 Jun 01; 328(6):L885-L900.
-
Gong J, Chan KS, Rajesh A, Droho S, Lavine JA. Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):43.
-
Strand R, Orlicky DJ, Chen Y. Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice. Biochem Biophys Res Commun. 2025 06 20; 766:151900.
-
Riccardi V, Viscomi CF, Sandri M, D'Alessandro A, Dzieciatkowska M, Stephenson D, Federti E, Hermann A, Salviati L, Siciliano A, Andolfo I, Alper SL, Ceolan J, Iolascon A, Vattemi G, Danek A, Walker RH, Mensch A, Otto M, Deschauer M, Armbrust M, Beninca' C, Salari V, Fabene P, Peikert K, De Franceschi L. Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy. Acta Neuropathol Commun. 2025 Apr 24; 13(1):83.
-
Posey JN, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik ES, Delaney C. Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension. Blood Adv. 2025 Apr 08; 9(7):1571-1584.
-
Hara N, Raclawska DS, Morgan LE, NeeDell JC, Dao L, Kato A, Jaramillo AM, Hume PS, Holguin F, Janssen WJ, Vladar EK, Evans CM. Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction. Am J Respir Cell Mol Biol. 2025 Apr; 72(4):408-417.
-
Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC. The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection. Nat Commun. 2025 Mar 25; 16(1):2923.
-
Schaunaman N, Cervantes D, Ferrington DA, Chu HW. Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness. Front Immunol. 2025; 16:1501898.
-
Rajesh A, Gong J, Chan KS, Viniak R, Droho S, Kachar D, Strauss JY, Wang AL, Lavine JA. The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice. J Neuroinflammation. 2025 Mar 07; 22(1):70.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|