 Caffeine
"Caffeine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
| Descriptor ID |
D002110
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| MeSH Number(s) |
D03.132.960.175 D03.633.100.759.758.824.175
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caffeine".
Below are MeSH descriptors whose meaning is more specific than "Caffeine".
This graph shows the total number of publications written about "Caffeine" by people in this website by year, and whether "Caffeine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1996 | 1 | 1 | 2 | | 1997 | 2 | 1 | 3 | | 1998 | 0 | 1 | 1 | | 2000 | 1 | 1 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 3 | 1 | 4 | | 2010 | 0 | 4 | 4 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 4 | 5 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 1 | 3 | | 2015 | 2 | 1 | 3 | | 2016 | 3 | 0 | 3 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 2 | 3 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caffeine" by people in Profiles.
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Strickland JC, Tilton HE, Patton NM, Vandrey R, Austin Zamarripa C, Spindle TR, Lee DC, Bergeria CL, Wolinsky D, Klawitter J, Sempio C, Campos-Palomino J, Christians U, Feldner MT, Irons JG, Bonn-Miller MO. Effect of caffeine and cannabidiol (CBD) co-administration on ?9-tetrahydrocannabinol (?9-THC) subjective effects, performance impairment, and pharmacokinetics. Neuropsychopharmacology. 2025 Nov; 50(12):1827-1835.
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Sturm H, Basalely A, Singer P, Castellanos L, Frank R, Sethna CB. Caffeine intake and cardiometabolic risk factors in adolescents in the United States. Pediatr Res. 2025 Apr; 97(5):1650-1658.
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Murray KO, Brant JO, Spradlin RA, Thome T, Laitano O, Ryan TE, Riva A, Kladde MP, Clanton TL. Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice. Am J Physiol Regul Integr Comp Physiol. 2024 02 01; 326(2):R160-R175.
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Barley BK, Gao C, Luster T, Porro A, Parizi-Robinson M, Quigley D, Zinke P, Scullin MK. Chronotype in college science students is associated with behavioral choices and can fluctuate across a semester. Chronobiol Int. 2023 06 03; 40(6):710-724.
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Weiss ST, Veach LJ, McGill W, Brent J. Rates and types of urine drug screen false negative results compared with confirmatory toxicology testing in major trauma patients. Clin Toxicol (Phila). 2022 10; 60(10):1122-1129.
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Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 05 18; 9(10):e015785.
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D'Alessandro A, Fu X, Reisz JA, Kanias T, Page GP, Stone M, Kleinman S, Zimring JC, Busch M. Stored RBC metabolism as a function of caffeine levels. Transfusion. 2020 06; 60(6):1197-1211.
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Mandell EW, Kratimenos P, Abman SH, Steinhorn RH. Drugs for the Prevention and Treatment of Bronchopulmonary Dysplasia. Clin Perinatol. 2019 06; 46(2):291-310.
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Arnold MR, Williams PH, McArthur JA, Archuleta AR, O'Neill CE, Hassell JE, Smith DG, Bachtell RK, Lowry CA. Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems. Neuropharmacology. 2019 04; 148:257-271.
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Lawther AJ, Flavell A, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior. Neuroscience. 2018 10 15; 390:88-103.
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