 STAT1 Transcription Factor
"STAT1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.
| Descriptor ID |
D050794
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| MeSH Number(s) |
D12.644.360.024.303.500.500 D12.644.360.024.342.100 D12.776.157.057.061.500.500 D12.776.157.057.186.100 D12.776.260.513.249.500 D12.776.476.024.386.500.500 D12.776.476.024.430.100 D12.776.930.354.249.500 D12.776.930.840.100
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| Concept/Terms |
STAT1 Transcription Factor- STAT1 Transcription Factor
- Transcription Factor, STAT1
- Transcription Factor STAT91
- Gamma-Activated Factor, 91 kDa
- Gamma Activated Factor, 91 kDa
- STAT-91 Transcription Factor
- STAT 91 Transcription Factor
- Transcription Factor, STAT-91
- STAT-91 Protein
- STAT 91 Protein
- STAT91 Transcription Factor
- Transcription Factor, STAT91
- STAT1 Protein
- Signal Transducer and Activator of Transcription 1
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Below are MeSH descriptors whose meaning is more general than "STAT1 Transcription Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
- STAT1 Transcription Factor [D12.644.360.024.303.500.500]
- STAT Transcription Factors [D12.644.360.024.342]
- STAT1 Transcription Factor [D12.644.360.024.342.100]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
- STAT1 Transcription Factor [D12.776.157.057.061.500.500]
- STAT Transcription Factors [D12.776.157.057.186]
- STAT1 Transcription Factor [D12.776.157.057.186.100]
- DNA-Binding Proteins [D12.776.260]
- Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
- STAT1 Transcription Factor [D12.776.260.513.249.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
- STAT1 Transcription Factor [D12.776.476.024.386.500.500]
- STAT Transcription Factors [D12.776.476.024.430]
- STAT1 Transcription Factor [D12.776.476.024.430.100]
- Transcription Factors [D12.776.930]
- Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
- STAT1 Transcription Factor [D12.776.930.354.249.500]
- STAT Transcription Factors [D12.776.930.840]
- STAT1 Transcription Factor [D12.776.930.840.100]
Below are MeSH descriptors whose meaning is more specific than "STAT1 Transcription Factor".
This graph shows the total number of publications written about "STAT1 Transcription Factor" by people in this website by year, and whether "STAT1 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 3 | 4 | | 2011 | 3 | 2 | 5 | | 2012 | 1 | 1 | 2 | | 2013 | 2 | 3 | 5 | | 2014 | 2 | 2 | 4 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 | | 2024 | 0 | 1 | 1 | | 2025 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "STAT1 Transcription Factor" by people in Profiles.
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Souto EP, Gong P, Landua JD, Rajaram Srinivasan R, Ganesan A, Dobrolecki LE, Purdy SC, Pan X, Zeosky M, Chung A, Yi SS, Ford HL, Lewis MT. Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor-Initiating Cells Characterized by IFN/STAT1 Activity. Cancer Res. 2025 Apr 15; 85(8):1390-1409.
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Han AL, Vinod Paul K, Rao S, Brechbuhl HM, Sartorius CA, Ramachandran S, Kabos P. Estradiol (E2) concentration shapes the chromatin binding landscape of estrogen receptor alpha. J Biol Chem. 2025 Jul; 301(7):108499.
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Pardy RD, Walzer KA, Wallbank BA, Byerly JH, O'Dea KM, Cohn IS, Haskins BE, Roncaioli JL, Smith EJ, Buenconsejo GY, Striepen B, Hunter CA. Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-? on parasite restriction. PLoS Pathog. 2024 May; 20(5):e1011820.
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Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F. Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. PLoS Pathog. 2023 06; 19(6):e1011185.
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Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. Elife. 2023 04 24; 12.
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Kaviany S, Bartkowiak T, Dulek DE, Khan YW, Hayes MJ, Schaefer SG, Ye X, Dahunsi DO, Connelly JA, Irish JM, Rathmell JC. Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. Immunohorizons. 2022 07 15; 6(7):447-464.
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Roach CM, Bidne KL, Romoser MR, Ross JW, Baumgard LH, Keating AF. Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts. J Anim Sci. 2022 Jul 01; 100(7).
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Arbelaez CA, Palle P, Charaix J, Bettelli E. STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation. JCI Insight. 2022 06 22; 7(12).
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Knitz MW, Darragh LB, Bickett TE, Bhatia S, Bukkapatnam S, Gadwa J, Piper M, Corbo S, Nguyen D, Van Court B, Oweida A, Karam SD. Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2022 May; 71(5):1049-1061.
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Ptacek J, Hawtin RE, Sun D, Louie B, Evensen E, Mittleman BB, Cesano A, Cavet G, Bingham CO, Cofield SS, Curtis JR, Danila MI, Raman C, Furie RA, Genovese MC, Robinson WH, Levesque MC, Moreland LW, Nigrovic PA, Shadick NA, O'Dell JR, Thiele GM, Clair EWS, Striebich CC, Hale MB, Khalili H, Batliwalla F, Aranow C, Mackay M, Diamond B, Nolan GP, Gregersen PK, Bridges SL. Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity. PLoS One. 2021; 16(1):e0244187.
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