 STAT1 Transcription Factor
"STAT1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.
| Descriptor ID |
D050794
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| MeSH Number(s) |
D12.644.360.024.303.500.500 D12.644.360.024.342.100 D12.776.157.057.061.500.500 D12.776.157.057.186.100 D12.776.260.513.249.500 D12.776.476.024.386.500.500 D12.776.476.024.430.100 D12.776.930.354.249.500 D12.776.930.840.100
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| Concept/Terms |
STAT1 Transcription Factor- STAT1 Transcription Factor
- Transcription Factor, STAT1
- Transcription Factor STAT91
- Gamma-Activated Factor, 91 kDa
- Gamma Activated Factor, 91 kDa
- STAT-91 Transcription Factor
- STAT 91 Transcription Factor
- Transcription Factor, STAT-91
- STAT-91 Protein
- STAT 91 Protein
- STAT91 Transcription Factor
- Transcription Factor, STAT91
- STAT1 Protein
- Signal Transducer and Activator of Transcription 1
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Below are MeSH descriptors whose meaning is more general than "STAT1 Transcription Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
- STAT1 Transcription Factor [D12.644.360.024.303.500.500]
- STAT Transcription Factors [D12.644.360.024.342]
- STAT1 Transcription Factor [D12.644.360.024.342.100]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
- STAT1 Transcription Factor [D12.776.157.057.061.500.500]
- STAT Transcription Factors [D12.776.157.057.186]
- STAT1 Transcription Factor [D12.776.157.057.186.100]
- DNA-Binding Proteins [D12.776.260]
- Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
- STAT1 Transcription Factor [D12.776.260.513.249.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
- STAT1 Transcription Factor [D12.776.476.024.386.500.500]
- STAT Transcription Factors [D12.776.476.024.430]
- STAT1 Transcription Factor [D12.776.476.024.430.100]
- Transcription Factors [D12.776.930]
- Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
- STAT1 Transcription Factor [D12.776.930.354.249.500]
- STAT Transcription Factors [D12.776.930.840]
- STAT1 Transcription Factor [D12.776.930.840.100]
Below are MeSH descriptors whose meaning is more specific than "STAT1 Transcription Factor".
This graph shows the total number of publications written about "STAT1 Transcription Factor" by people in this website by year, and whether "STAT1 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 3 | 4 | | 2011 | 3 | 2 | 5 | | 2012 | 1 | 1 | 2 | | 2013 | 2 | 3 | 5 | | 2014 | 2 | 2 | 4 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "STAT1 Transcription Factor" by people in Profiles.
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Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F. Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. PLoS Pathog. 2023 06; 19(6):e1011185.
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Kaviany S, Bartkowiak T, Dulek DE, Khan YW, Hayes MJ, Schaefer SG, Ye X, Dahunsi DO, Connelly JA, Irish JM, Rathmell JC. Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. Immunohorizons. 2022 Jul 15; 6(7):447-464.
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Roach CM, Bidne KL, Romoser MR, Ross JW, Baumgard LH, Keating AF. Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts. J Anim Sci. 2022 Jul 01; 100(7).
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Knitz MW, Darragh LB, Bickett TE, Bhatia S, Bukkapatnam S, Gadwa J, Piper M, Corbo S, Nguyen D, Van Court B, Oweida A, Karam SD. Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2022 May; 71(5):1049-1061.
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Ptacek J, Hawtin RE, Sun D, Louie B, Evensen E, Mittleman BB, Cesano A, Cavet G, Bingham CO, Cofield SS, Curtis JR, Danila MI, Raman C, Furie RA, Genovese MC, Robinson WH, Levesque MC, Moreland LW, Nigrovic PA, Shadick NA, O'Dell JR, Thiele GM, Clair EWS, Striebich CC, Hale MB, Khalili H, Batliwalla F, Aranow C, Mackay M, Diamond B, Nolan GP, Gregersen PK, Bridges SL. Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity. PLoS One. 2021; 16(1):e0244187.
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Hu J, Zhang L, Liechty C, Zgheib C, Hodges MM, Liechty KW, Xu J. Long Noncoding RNA GAS5 Regulates Macrophage Polarization and Diabetic Wound?Healing. J Invest Dermatol. 2020 08; 140(8):1629-1638.
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Walrath T, Malizia RA, Zhu X, Sharp SP, D'Souza SS, Lopez-Soler R, Parr B, Kartchner B, Lee EC, Stain SC, Iwakura Y, O'Connor W. IFN-? and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G479-G489.
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Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P. Transcriptional Responses to IFN-? Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Mol Cell. 2019 11 07; 76(3):485-499.e8.
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McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFN? Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018; 9:2210.
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Patel ZH, Lu X, Miller D, Forney CR, Lee J, Lynch A, Schroeder C, Parks L, Magnusen AF, Chen X, Pujato M, Maddox A, Zoller EE, Namjou B, Brunner HI, Henrickson M, Huggins JL, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Pons-Estel BA, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarc?n GS, Martin J, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vil? LM, Petri M, Scofield RH, Kimberly RP, Edberg JC, Ramsey-Goldman R, Bang SY, Lee HS, Bae SC, Boackle SA, Cunninghame Graham D, Vyse TJ, Merrill JT, Niewold TB, Ainsworth HC, Silverman ED, Weisman MH, Wallace DJ, Raj P, Guthridge JM, Gaffney PM, Kelly JA, Alarc?n-Riquelme ME, Langefeld CD, Wakeland EK, Kaufman KM, Weirauch MT, Harley JB, Kottyan LC. A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet. 2018 07 01; 27(13):2392-2404.
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