 Cellular Senescence
"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
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| MeSH Number(s) |
G04.043
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| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
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Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 | | 1997 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 2 | 3 | | 2003 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 2 | 4 | | 2008 | 1 | 2 | 3 | | 2009 | 3 | 2 | 5 | | 2010 | 4 | 2 | 6 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 2 | 5 | | 2013 | 5 | 4 | 9 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 5 | 7 | | 2016 | 6 | 3 | 9 | | 2017 | 1 | 0 | 1 | | 2018 | 3 | 3 | 6 | | 2019 | 7 | 3 | 10 | | 2020 | 2 | 1 | 3 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 2 | 3 | | 2023 | 2 | 5 | 7 | | 2024 | 4 | 2 | 6 | | 2025 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
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Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy MK, Bruce J, Leblanc L, Hadjou Y, Georgeault S, Fricot A, Roussel C, Stephenson D, Casimir M, Sissoko A, Paye F, Dokmak S, Ndour PA, Roingeard P, Gautier EF, Spitalnik SL, Hermine O, Buffet PA, D'Alessandro A, Amireault P. Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance. J Clin Invest. 2025 May 01; 135(9).
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Gross PS, Dur?n-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.
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Srour E, Martin N, Drullion C, De Schutter C, Giroud J, Pioger A, Desl? J, Saas L, Nassour J, Th?ry J, Decanter G, Penel N, Vercamer C, Salazar-Cardozo C, Abbadie C, Pluquet O. Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes. Aging (Albany NY). 2024 Nov 18; 16(21):13201-13224.
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Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Sim?es-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024 Nov 07; 31(11):1574-1590.e11.
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Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Vollmer A, Karns R, Sacma M, Nemkov T, D'Alessandro A, Geiger H. Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment. Aging Cell. 2024 Oct; 23(10):e14324.
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Smart M, Moreno DF, Acar M. Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs. Cell Syst. 2024 Aug 21; 15(8):676-678.
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Cooksley G, Nam MH, Nahomi RB, Rankenberg J, Smith AJO, Wormstone YM, Wormstone IM, Nagaraj RH. Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts. Aging Cell. 2024 Oct; 23(10):e14249.
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Prince EW, Apps JR, Jeang J, Chee K, Medlin S, Jackson EM, Dudley R, Limbrick D, Naftel R, Johnston J, Feldstein N, Prolo LM, Ginn K, Niazi T, Smith A, Kilburn L, Chern J, Leonard J, Lam S, Hersh DS, Gonzalez-Meljem JM, Amani V, Donson AM, Mitra SS, Bandopadhayay P, Martinez-Barbera JP, Hankinson TC. Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis. Neuro Oncol. 2024 06 03; 26(6):1109-1123.
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Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 03; 23(3):e14060.
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Nassour J, Przetocka S, Karlseder J. Telomeres as hotspots for innate immunity and inflammation. DNA Repair (Amst). 2024 Jan; 133:103591.
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