 Cellular Senescence
"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
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| MeSH Number(s) |
G04.043
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| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
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Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 3 | 5 | | 2008 | 1 | 3 | 4 | | 2009 | 3 | 1 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 3 | 6 | | 2013 | 5 | 4 | 9 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 4 | 6 | | 2016 | 6 | 3 | 9 | | 2017 | 3 | 0 | 3 | | 2018 | 3 | 5 | 8 | | 2019 | 7 | 3 | 10 | | 2020 | 3 | 1 | 4 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 2 | 3 | | 2023 | 2 | 6 | 8 | | 2024 | 4 | 4 | 8 | | 2025 | 13 | 1 | 14 | | 2026 | 1 | 3 | 4 |
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Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
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Mahoney SA, Mazan-Mamczarz K, Tsitsipatis D, VanDongen NS, Henry-Smith C, Okereke AN, Munk R, Darvish S, Murray KO, De S, Gorospe M, Seals DR, Rossman MJ, Herman AB, Clayton ZS. Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. Aging Cell. 2026 May; 25(5):e70500.
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Darrah MA, Mahoney SA, Venkatasubramanian R, VanDongen NS, Ludwig KR, Seals DR, Rossman MJ, Clayton ZS. Fisetin Supplementation Attenuates Premature Vascular Aging Induced by Doxorubicin via Suppression of Cellular Senescence and Mitochondrial Oxidative Stress. Aging Cell. 2026 May; 25(5):e70535.
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Redente EF, Song T, Javkhlan N, Edelman BL, Foster DG, Wilson JA, Chakraborty S, Cooley JC, Gaurav R, Saguthi S, Seibold MA, Blumhagen RZ, Schwartz DA, Yang IV, Matsuda J, Bridges JP, Zemans RL, Tuder RM, Riches DWH. Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition. Nat Commun. 2026 Feb 28; 17(1).
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Ghosh S, Devereaux MW, Anderson AL, Anderson CC, D'Alessandro A, Orlicky DJ, Sokol RJ. Dietary Lauric Acid Suppresses Inflammation, Cholestasis, Hepatocyte Injury, and Senescence in 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced Inflammatory Cholangiopathy. Cell Mol Gastroenterol Hepatol. 2026; 20(5):101731.
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Singer J, Chow L, Ammons D, Sabino I, Impastato R, Dow S, Pezzanite LM. Senescence-associated gene pathways are differentially expressed in equine aging-related osteoarthritis. Am J Vet Res. 2026 Apr 01; 87(4).
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Fernandez B, Passanisi VJ, Ashraf HM, Spencer SL. Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy. Nat Commun. 2025 Dec 23; 17(1):169.
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Tufa DM, Hoffmeyer E, Schaller KL, Kooiman B, Woods E, Wang D, Jones D, Hall S, Cruz JC, Verneris MR. Innate lymphoid cells prevent graft-versus-host disease via IL-9-driven T-cell senescence. Blood. 2025 Nov 27; 146(22):2656-2669.
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Walrath TM, Evans MR, Meza Monge K, Najarro KM, Orlicky DJ, Idrovo JP, McMahan RH, Kovacs EJ. Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice. Am J Physiol Gastrointest Liver Physiol. 2026 01 01; 330(1):G1-G9.
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Singh P, Venkatasubramanian R, Mahoney SA, Darrah MA, Ludwig KR, Zhang A, Kaneshiro K, Najera LE, Wimer L, Shanmugam MM, Morazan E, Galligan JJ, Trujillo MN, Sarpong R, Seals DR, Kapahi P, Clayton ZS. Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence. Aging (Albany NY). 2025 11 14; 17(11):2717-2743.
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Venkatasubramanian R, Mahoney SA, Hutton DA, VanDongen NS, Brunt VE, Greenberg NT, Longtine AG, Brandt L, Beyer AM, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment. Am J Physiol Heart Circ Physiol. 2025 12 01; 329(6):H1672-H1683.
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