 RNA Precursors
"RNA Precursors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.
| Descriptor ID |
D012322
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| MeSH Number(s) |
D13.400.730 D13.444.735.640
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| Concept/Terms |
RNA Precursor- RNA Precursor
- Precursor, RNA
- Precursor RNA
- RNA, Precursor
Primary RNA Transcript- Primary RNA Transcript
- RNA Transcript, Primary
- Transcript, Primary RNA
- Primary Transcript, RNA
- RNA Primary Transcript
- Transcript, RNA Primary
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Below are MeSH descriptors whose meaning is more general than "RNA Precursors".
Below are MeSH descriptors whose meaning is more specific than "RNA Precursors".
This graph shows the total number of publications written about "RNA Precursors" by people in this website by year, and whether "RNA Precursors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 1 | 2 | | 1996 | 2 | 1 | 3 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 2 | 3 | | 2004 | 2 | 0 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 1 | 3 | | 2008 | 2 | 1 | 3 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 2 | 4 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 3 | 4 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "RNA Precursors" by people in Profiles.
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Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337.
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Shenasa H, Bentley DL. Pre-mRNA splicing and its cotranscriptional connections. Trends Genet. 2023 09; 39(9):672-685.
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Lee FFY, Alper S. Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling. Front Immunol. 2022; 13:1023567.
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Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308.
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Walter ND, Born SEM, Robertson GT, Reichlen M, Dide-Agossou C, Ektnitphong VA, Rossmassler K, Ramey ME, Bauman AA, Ozols V, Bearrows SC, Schoolnik G, Dolganov G, Garcia B, Musisi E, Worodria W, Huang L, Davis JL, Nguyen NV, Nguyen HV, Nguyen ATV, Phan H, Wilusz C, Podell BK, Sanoussi ND, de Jong BC, Merle CS, Affolabi D, McIlleron H, Garcia-Cremades M, Maidji E, Eshun-Wilson F, Aguilar-Rodriguez B, Karthikeyan D, Mdluli K, Bansbach C, Lenaerts AJ, Savic RM, Nahid P, V?squez JJ, Voskuil MI. Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens. Nat Commun. 2021 05 18; 12(1):2899.
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Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021 04 15; 12(1):2259.
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Saldi T, Riemondy K, Erickson B, Bentley DL. Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing. Mol Cell. 2021 04 15; 81(8):1789-1801.e5.
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De Bortoli F, Espinosa S, Zhao R. DEAH-Box RNA Helicases in Pre-mRNA Splicing. Trends Biochem Sci. 2021 03; 46(3):225-238.
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Shenasa H, Movassat M, Forouzmand E, Hertel KJ. Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly. RNA. 2020 10; 26(10):1389-1399.
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Lee FF, Davidson K, Harris C, McClendon J, Janssen WJ, Alper S. NF-?B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages. J Biol Chem. 2020 05 01; 295(18):6236-6248.
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