 Down-Regulation
"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
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| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
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| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 3 | 4 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 4 | 4 | | 1998 | 1 | 3 | 4 | | 1999 | 0 | 3 | 3 | | 2000 | 2 | 7 | 9 | | 2001 | 3 | 8 | 11 | | 2002 | 0 | 13 | 13 | | 2003 | 2 | 14 | 16 | | 2004 | 6 | 13 | 19 | | 2005 | 2 | 18 | 20 | | 2006 | 4 | 21 | 25 | | 2007 | 1 | 17 | 18 | | 2008 | 4 | 20 | 24 | | 2009 | 2 | 20 | 22 | | 2010 | 6 | 22 | 28 | | 2011 | 6 | 18 | 24 | | 2012 | 5 | 18 | 23 | | 2013 | 5 | 16 | 21 | | 2014 | 0 | 16 | 16 | | 2015 | 5 | 15 | 20 | | 2016 | 3 | 18 | 21 | | 2017 | 5 | 30 | 35 | | 2018 | 0 | 11 | 11 | | 2019 | 2 | 15 | 17 | | 2020 | 1 | 9 | 10 | | 2021 | 2 | 8 | 10 | | 2022 | 1 | 5 | 6 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 3 | 3 | | 2025 | 1 | 4 | 5 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Singh N, Ali M, Biswal P, Jaiswal A, Mishra D, Agarwal R, Zaidi R, Singh RP. Inhibition of Growth and Survival of Head and Neck Cancer Cells by Silibinin Involves the Down-Regulation of Erk1/2, AKT and STAT3 Signaling. Mol Carcinog. 2025 Oct; 64(10):1735-1750.
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Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNF-a impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation. J Clin Invest. 2025 Aug 01; 135(15).
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Jeffrey DA, Dockstader K, Revoredo Vicentino A, Slavov DB, Miyamoto SD, Stauffer BL, Sucharov CC. Muscle-specific isoforms of FXR1 are necessary for miR-1-mediated repression of connexin 43 and are downregulated in pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2025 Jun 01; 328(6):H1380-H1390.
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Ravi P, Jasuja H, Sarkar D, Vahidi Pashaki B, Gaikwad HK, Vahidi Pashaki P, Katti DR, Shetty K, Katti KS. Rhodiola crenulata induces apoptosis in bone metastatic breast cancer cells via activation of caspase-9 and downregulation of MtMP activity. Sci Rep. 2025 Mar 18; 15(1):9341.
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Agraval H, Gao J, Schaunaman N, Hua H, Vandivier RW, Numata M, Day BJ, Chu HW. Toll-Interacting Protein Down-Regulation by Cigarette Smoke Exposure Impairs Human Lung Defense against Influenza A Virus Infection. Am J Pathol. 2025 Jun; 195(6):1124-1140.
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Wright RS, Raal FJ, Koenig W, Landmesser U, Leiter LA, Vikarunnessa S, Lesogor A, Maheux P, Talloczy Z, Zang X, Schwartz GG, Ray KK. Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial. Cardiovasc Res. 2024 10 14; 120(12):1400-1410.
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Santos-Cortez RLP, Gomez HZ, Elling CL, Mayher L, Diala OR, Gardner C, Willford K, Zamora VC, Agyepong A, Lee NK, Green KK, Darr OA, Wine TM, Francom CR, Larson ED, Gitomer SA, Schell AE, Frank DN, Friedman NR, Herrmann BW. APOBR Is Downregulated in EBV+ Tonsils of Children with Obstructive Sleep-Disordered Breathing. Genes (Basel). 2024 Oct 14; 15(10).
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Fiske BE, Getahun A. Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help. J Immunol. 2024 Apr 01; 212(7):1150-1160.
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Ravindran Menon D, Hammerlindl H, Gimenez G, Hammerlindl S, Zuegner E, Torrano J, Bordag N, Emran AA, Giam M, Denil S, Pavelka N, Tan AC, Sturm RA, Haass NK, Rancati G, Herlyn M, Magnes C, Eccles MR, Fujita M, Schaider H. H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase. Drug Resist Updat. 2023 Nov; 71:100993.
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Tyagi A, Musa M, Labeikovsky W, Pugazhenthi S. Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome. Sci Rep. 2022 11 17; 12(1):19808.
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