 Interleukin-1 Receptor-Associated Kinases
"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.
| Descriptor ID |
D053592
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| MeSH Number(s) |
D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
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| Concept/Terms |
Interleukin-1 Receptor-Associated Kinases- Interleukin-1 Receptor-Associated Kinases
- Interleukin 1 Receptor Associated Kinases
- Kinases, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinases, Interleukin-1
- IRAK Kinases
- Kinases, IRAK
- IL-1 Receptor-Associated Kinase
- IL 1 Receptor Associated Kinase
- Kinase, IL-1 Receptor-Associated
- Receptor-Associated Kinase, IL-1
- Interleukin-1 Receptor-Associated Kinase
- Interleukin 1 Receptor Associated Kinase
- Kinase, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinase, Interleukin-1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".
This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 3 | 3 | | 2019 | 2 | 0 | 2 | | 2020 | 1 | 2 | 3 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.
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Ho TC, LaMere MW, Kawano H, Byun DK, LaMere EA, Chiu YC, Chen C, Wang LJ, Wang J, Ramdas B, Dokholyan NV, Calvi LM, Liesveld JL, Jordan CT, Singh RK, Kapur R, Becker MW. Targeting IL-1/IRAK1/4 signaling in acute myeloid leukemia stem cells following treatment and relapse. Leukemia. 2026 Feb; 40(2):293-303.
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Geng D, Chen J, Sanchez A, Davalos SA, Wilcox P, Gonzales-Rivera D, Couts K, Tobin R, Robinson W, Nielsen AJ, Guo J, McCarter M, Crump L, Tsujimoto K, Wilky BA, Davila E. Melanoma leverages innate immune IRAK-M signaling to limit metastasis through PTPN22-Induced signaling repression. Cancer Lett. 2026 Feb 28; 639:218172.
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Hook JS, Matheis AD, Kavanaugh JS, Horswill AR, Moreland JG. Role for IRAK-4 and p38 in Neutrophil Signaling in Response to Bacterial Lipoproteins from Staphylococcus aureus. Inflammation. 2025 Aug; 48(4):1704-1715.
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Wang Q, Notay K, Downey GP, McCulloch CA. The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation. Cell Rep. 2020 06 30; 31(13):107781.
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Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol. 2020 06 12; 3(1):306.
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Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Amin MA, Zomorrodi RK, Arami S, Gonzalez M, Rao V, Zanotti B, Fox DA, Sweiss N, Shahrara S. IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion. Cell Mol Immunol. 2021 09; 18(9):2199-2210.
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Zhang Y, Diao N, Lee CK, Chu HW, Bai L, Li L. Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses. Mol Ther. 2020 01 08; 28(1):89-99.
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Dakhama A, Al Mubarak R, Pavelka N, Voelker D, Seibold M, Ledford JG, Kraft M, Li L, Chu HW. Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus. J Innate Immun. 2020; 12(1):103-115.
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Berman R, Downey GP, Dakhama A, Day BJ, Chu HW. Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling. Toxicol Sci. 2018 Dec 01; 166(2):345-353.
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Ito Y, Schaefer N, Sanchez A, Francisco D, Alam R, Martin RJ, Ledford JG, Stevenson C, Jiang D, Li L, Kraft M, Chu HW. Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice. J Innate Immun. 2018; 10(2):106-118.
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