 Up-Regulation
"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
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| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
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| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 6 | 7 | | 1999 | 1 | 4 | 5 | | 2000 | 0 | 4 | 4 | | 2001 | 2 | 9 | 11 | | 2002 | 4 | 20 | 24 | | 2003 | 1 | 16 | 17 | | 2004 | 3 | 22 | 25 | | 2005 | 2 | 27 | 29 | | 2006 | 5 | 27 | 32 | | 2007 | 4 | 28 | 32 | | 2008 | 4 | 17 | 21 | | 2009 | 2 | 26 | 28 | | 2010 | 2 | 23 | 25 | | 2011 | 8 | 27 | 35 | | 2012 | 9 | 31 | 40 | | 2013 | 3 | 27 | 30 | | 2014 | 2 | 23 | 25 | | 2015 | 5 | 21 | 26 | | 2016 | 2 | 26 | 28 | | 2017 | 2 | 20 | 22 | | 2018 | 5 | 24 | 29 | | 2019 | 2 | 26 | 28 | | 2020 | 4 | 18 | 22 | | 2021 | 5 | 7 | 12 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 3 | 2 | 5 | | 2025 | 0 | 6 | 6 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Hoyt-Miggelbrink AM, Waibl Polania J, Wachsmuth L, Lorrey S, Mohan A, Hardigan A, Blandford E, Lerner E, Wilkinson D, Hotchkiss KM, Cook S, Hemmers S, Patel A, Ayasoufi K, Fecci P. Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity. Clin Cancer Res. 2026 Feb 17; 32(4):782-800.
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Owaki A, Kaseda S, Tanigawa S, Miike K, Sannomiya Y, Tsuhako H, Sato R, Mizumoto K, Horizono J, Kumabe R, Tokuyasu M, Fujiwara Y, Takeo T, Araki K, Davenport B, Lennon R, Shuto T, Nishinakamura R, Suico MA, Kai H. Protective role of early Tnfsf15 upregulation in limiting glomerular injury and proteinuria in experimental Alport Syndrome. J Pharmacol Sci. 2026 Mar; 160(3):158-166.
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Gutierrez VA, Beede-James KF, Martin LE, Zumpano KT, Kay KE, Medler KF, Torregrossa AM. Functional bitter taste signaling and stimulus intensity influence diet-induced salivary protein upregulation. Appetite. 2026 Apr 01; 219:108418.
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Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.
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Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T. Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2026 Jan 01; 330(1):H124-H136.
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Roth R, Häckh M, Schnick T, Rommel C, Koentges C, Bugger H, Domisch C, Bristow MR, Ambardekar AV, McKinsey TA, Gilsbach R, Hein L, Preissl S. Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors. Epigenetics. 2025 Dec; 20(1):2506625.
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Dylla L, Reisz JA, Poisson SN, Herson PS, Sansing LH, Monte AA. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection: Kynurenine and post-stroke infection. J Stroke Cerebrovasc Dis. 2025 May; 34(5):108268.
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Voss DM, Kral AJ, Sim G, Utama R, Lin KT, Cizmeciyan C, Schafer B, Cunniff PJ, Vakoc CR, Caruthers MH, Mishra L, Krainer AR. PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma. J Biol Chem. 2025 04; 301(4):108345.
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Iacono G, Abay A, Murillo JSG, Aglialoro F, Yagci N, Varga E, Bijlsma T, Sohler J, Fu K, Reisz JA, Argabright A, D'Alessandro A, Svendsen AF, von Lindern M, van den Akker E. Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression. Sci Rep. 2024 12 04; 14(1):30157.
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Lind HT, Hall SC, Strait AA, Goon JB, Aleman JD, Chen SMY, Karam SD, Young CD, Wang JH, Wang XJ. MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-ß in squamous cell carcinomas with enhanced CD8 T cell memory-driven response. Cancer Lett. 2025 Jan 01; 608:217347.
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