 Protein Isoforms
"Protein Isoforms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
| Descriptor ID |
D020033
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| MeSH Number(s) |
D12.776.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Isoforms".
Below are MeSH descriptors whose meaning is more specific than "Protein Isoforms".
This graph shows the total number of publications written about "Protein Isoforms" by people in this website by year, and whether "Protein Isoforms" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 1 | 5 | 6 | | 2000 | 2 | 11 | 13 | | 2001 | 1 | 13 | 14 | | 2002 | 1 | 10 | 11 | | 2003 | 2 | 12 | 14 | | 2004 | 0 | 12 | 12 | | 2005 | 2 | 16 | 18 | | 2006 | 0 | 16 | 16 | | 2007 | 0 | 5 | 5 | | 2008 | 1 | 17 | 18 | | 2009 | 0 | 13 | 13 | | 2010 | 1 | 10 | 11 | | 2011 | 3 | 9 | 12 | | 2012 | 0 | 19 | 19 | | 2013 | 1 | 8 | 9 | | 2014 | 0 | 8 | 8 | | 2015 | 1 | 13 | 14 | | 2016 | 1 | 6 | 7 | | 2017 | 1 | 7 | 8 | | 2018 | 4 | 7 | 11 | | 2019 | 0 | 12 | 12 | | 2020 | 2 | 3 | 5 | | 2021 | 1 | 5 | 6 | | 2022 | 0 | 6 | 6 | | 2023 | 0 | 10 | 10 | | 2024 | 2 | 7 | 9 | | 2025 | 0 | 4 | 4 | | 2026 | 0 | 4 | 4 |
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Below are the most recent publications written about "Protein Isoforms" by people in Profiles.
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Sun C, Zhao J, Li N, Yao X, Wang Y, Kim CH, Bok J, Peng AW, Xu Z. Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice. Proc Natl Acad Sci U S A. 2026 Apr 21; 123(16):e2531564123.
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Li S, Jun S, Kim YR, Gogineni A, Lee F, Kim CH, Kim UK, Peng AW, Shin JB. A regulatory axis for tonotopic MYO7A expression in cochlear hair cells. Proc Natl Acad Sci U S A. 2026 Apr 14; 123(15):e2519742123.
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Witmer NH, Hoeger JM, McLendon JM, Stein CS, Yoon JY, Wang L, Berezhnaya E, Elrod JW, Knollmann BC, London B, Boudreau RL. Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism. Circ Res. 2026 Apr 24; 138(9):e326973.
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Bui S, Reineberg A, Jones D, Na CL, Kitzmiller J, Rodriguez LR, Murthy A, Iyer S, Cooper C, Chroneos R, Tomer Y, Mulugeta S, Weaver TE, Kotton DN, Alysandratos KD, Whitsett JA, Beers MF. Divergent pathways of surfactant protein C maturation for disease-associated isoforms. J Biol Chem. 2026 Mar; 302(3):111252.
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Neumann A, Prekeris R. Checking in with EPLIN: EPLINa as a regulator of integrin trafficking. Dev Cell. 2025 Nov 17; 60(22):3000-3001.
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Nguyen VT, Chandler C, Strang JE, Astridge DD, Reigan P. RiSKs in Computational Modeling of Isoform-Selective RSK Inhibitors. J Chem Inf Model. 2025 Aug 25; 65(16):8411-8425.
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Han Y, Binti S, Wennersten SA, Pandi B, Ng DC, Lau E, Lam MP. A ratiometric catalog of protein isoform shifts in the cardiac fetal gene program. JCI Insight. 2025 Sep 23; 10(18).
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Jeffrey DA, Dockstader K, Revoredo Vicentino A, Slavov DB, Miyamoto SD, Stauffer BL, Sucharov CC. Muscle-specific isoforms of FXR1 are necessary for miR-1-mediated repression of connexin 43 and are downregulated in pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2025 Jun 01; 328(6):H1380-H1390.
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Chakravarty D, Vedula P, Coffin M, Chen L, Sterling S, Peshkova AD, Suzuki A, Zhao L, Patra K, Assenmacher CA, Radaelli E, Levine M, Litvinov RI, Abrams CS, Fowler VM, Kashina A. ß-actin function in platelets and red blood cells can be performed by ?-actin and is therefore independent of actin isoform protein sequence. Mol Biol Cell. 2025 Feb 01; 36(2):ar18.
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Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen LL, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. Cell. 2024 Dec 26; 187(26):7621-7636.e19.
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