 Mutation
"Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
| Descriptor ID |
D009154
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| MeSH Number(s) |
G05.365.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mutation".
Below are MeSH descriptors whose meaning is more specific than "Mutation".
This graph shows the total number of publications written about "Mutation" by people in this website by year, and whether "Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 9 | 14 | | 1996 | 4 | 14 | 18 | | 1997 | 6 | 18 | 24 | | 1998 | 15 | 19 | 34 | | 1999 | 3 | 24 | 27 | | 2000 | 10 | 28 | 38 | | 2001 | 7 | 40 | 47 | | 2002 | 12 | 41 | 53 | | 2003 | 12 | 50 | 62 | | 2004 | 11 | 55 | 66 | | 2005 | 7 | 55 | 62 | | 2006 | 10 | 59 | 69 | | 2007 | 31 | 51 | 82 | | 2008 | 29 | 54 | 83 | | 2009 | 19 | 64 | 83 | | 2010 | 20 | 68 | 88 | | 2011 | 26 | 64 | 90 | | 2012 | 29 | 74 | 103 | | 2013 | 33 | 83 | 116 | | 2014 | 39 | 93 | 132 | | 2015 | 41 | 76 | 117 | | 2016 | 40 | 110 | 150 | | 2017 | 31 | 110 | 141 | | 2018 | 46 | 98 | 144 | | 2019 | 40 | 111 | 151 | | 2020 | 29 | 82 | 111 | | 2021 | 25 | 108 | 133 | | 2022 | 5 | 112 | 117 | | 2023 | 2 | 87 | 89 | | 2024 | 23 | 60 | 83 | | 2025 | 10 | 32 | 42 |
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Below are the most recent publications written about "Mutation" by people in Profiles.
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Tap WD, Cote GM, Burris H, Gore L, Elias A, Beeram M, Conley AP, Gianolio DA, Qu Z, Pandya S, Trent JC. Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Long-term Safety and Clinical Activity in Patients with Conventional Chondrosarcoma. Clin Cancer Res. 2025 Jun 03; 31(11):2108-2114.
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Lim EL, DeGregori J. The Nature and Nurture of Carcinogenesis. Cancer Discov. 2025 Jun 03; 15(6):1090-1092.
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Montani D, McLaughlin VV, Gibbs JSR, Gomberg-Maitland M, Hoeper MM, Preston IR, Souza R, Waxman AB, Escribano Subias P, Feldman J, Meyer GM, Olsson KM, Coulet F, Manimaran S, Zhao Y, Lau A, de Oliveira Pena J, Badesch DB, Humbert M. Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR). Am J Respir Crit Care Med. 2025 Jun; 211(6):1028-1037.
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Fritts RK, Ebmeier CC, Copley SD. Transcriptomic and proteomic ramifications of segmental amplification in Escherichia coli. Proc Natl Acad Sci U S A. 2025 May 20; 122(20):e2422424122.
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McMahon C, Raddi MG, Mohan S, Santini V. New Approvals in Low- and Intermediate-Risk Myelodysplastic Syndromes. Am Soc Clin Oncol Educ Book. 2025 Jun; 45(3):e473654.
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Soupir A, Ospina OE, Hampton O, Churchman M, Radmacher M, Hedges D, McKean D, Agius P, Zeeshan S, Seligson ND, Pollock R, Liebner D, Chen JL, Tinoco G, Salhia B, McCarter M, Wilky BA, Miller BJ, Cavnar MJ, Groundland JS, Schneider BP, Riedlinger G, Edge SB, Moskaluk CA, Cardona K, Naqash AR, Gonzalez RJ, Mullinax JE, Joyce DM, Binitie O, Douglas Letson G, Naghavi AO, Druta M, Reed DR, Siegel EM, Teer JK, Fridley BL, Brohl AS. Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes. Nat Commun. 2025 May 06; 16(1):4206.
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Lawson-Michod KA, Marks JR, Collin LJ, Nix DA, Davidson NR, Huff CD, Yu Y, Atkinson A, Johnson CE, Salas LA, Peres LC, Greene CS, Schildkraut JM, Doherty JA. Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals. Cancer Res. 2025 May 02; 85(9):1725-1737.
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Rai M, Li H, Policastro RA, Pepin R, Zentner GE, Nemkov T, D'Alessandro A, Tennessen JM. Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3. PLoS Genet. 2025 May; 21(5):e1011690.
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Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Sarosiek K, Hughes PE, Hata AN. LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers. Nat Commun. 2025 May 02; 16(1):4112.
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Barsouk A, Elghawy O, Watts A, Reed-Guy L, Tompkins W, Chandrasekhara K, Grady CB, Iams W, Sun F, Liu G, Patel D, Nieva JJ, Marrone KA, Velcheti V, Liu SV, Patil T, Weiss J, Schwartzman W, Villaruz LC, Hermann A, Aisner DL, Hwang WT, Camidge DR, Sun L, Singh AP, Cohen RB, Aggarwal C, Langer CJ, Marmarelis ME. Osimertinib vs. Afatinib in 1L therapy of atypical EGFR-mutated metastatic non-small cell lung cancer (mNSCLC): A multi-institution, real-world survival analysis. Lung Cancer. 2025 May; 203:108551.
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