 Neurofilament Proteins
"Neurofilament Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
| Descriptor ID |
D016900
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| MeSH Number(s) |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".
Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".
This graph shows the total number of publications written about "Neurofilament Proteins" by people in this website by year, and whether "Neurofilament Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 2 | 1 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 3 | 0 | 3 | | 2025 | 1 | 5 | 6 |
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Below are the most recent publications written about "Neurofilament Proteins" by people in Profiles.
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Vugmeyster L, Frazier B, Fu R, Ostrovsky D. Multi-mode water dynamics in hydration shells of villin headpiece subdomain protein in the solid state using deuterium and oxygen-17 NMR spectroscopy. J Chem Phys. 2025 Jul 14; 163(2).
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Garcia-Cordero I, Vargas-Gonzalez JC, Hadian M, Bayram E, Rodriguez-Porcel F, Couto B, Iyer J, Golbe LI, Stephen CD, Pantelyat A, Dale ML, McFarland N, Xie T, Swan M, Kang K, Gunzler D, Wills AM, Boxer A, Litvan I, Lang A, Tartaglia MC. Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70485.
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Janas AM, Miller KR, Ceschin R, Mourani PM, Ruzas CM, Bennett TD, Fink EL, Maddux AB. Early Blood Biomarkers and MRI Injury After Cardiac Arrest: Secondary Analysis of the 2017-2020 Personalized Outcomes After Child Cardiac Arrest Study. Pediatr Crit Care Med. 2025 Jul 01; 26(7):e915-e923.
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Memel M, Staffaroni AM, Ilan-Gala I, Castro JG, Kornak J, Tartaglia CM, Saloner R, VandeBunte AM, Paolillo EW, Cadwallader CJ, Chen C, Gorno-Tempini ML, Mandelli M, Apostolova L, Graff-Radford N, Litvan I, Bayram E, Pressman PS, Miyagawa T, Mackenzie I, Goldman J, Darby RR, Appleby BS, Petrucelli L, Gendron T, Heuer HW, Forseberg LK, Rojas JC, Boeve BF, Brushaber N, Domoto-Reilly K, Ghoshal N, Lapid M, Pascual B, Lee S, Ramos EM, Ramanan V, Rademakers R, Rascovsky K, Pantelyat A, Masdeu JC, Snyder A, Boxer AL, Rosen HJ, Casaletto K. Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia. Alzheimers Dement. 2025 Apr; 21(4):e14630.
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Sanchez E, Coughlan GT, Wilkinson T, Ramirez J, Mirza SS, Baril AA, Dilliott AA, Frank A, Lang AE, Hassan A, Pollock BG, Scott CJM, Marras C, Fischer CE, Seitz D, Andriuta D, Dowlatshahi D, Grimes DA, Tang-Wai DF, Sahlas DJ, Rogaeva EA, Finger E, Robinson JF, Tan K, Binns MA, Tartaglia MC, Borrie MJ, Strong MJ, Ozzoude M, Nanayakkara ND, Goncalves RA, Bartha R, Hegele RA, Farhan SMK, Black SE, Kumar S, Symons SP, Haddad SMH, Pasternak SH, Arnott SR, Rajji TK, Steeves T, Swardfager W, Ashton NJ, Kvartsberg H, Zetterberg H, Munoz DP, Masellis M. Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases. Neurology. 2025 04 08; 104(7):e213438.
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Schoeps VA, Bhargava P, Virupakshaiah A, Ladakis DC, Moseley C, Chong J, Aaen G, Graves JS, Benson L, Gorman MP, Rensel M, Abrams A, Mar S, Lotze TE, Chitnis T, Waldman A, Krupp L, Rodriguez M, Tillema JM, Rose J, Schreiner T, Qureshi F, Peterson S, Barcellos LF, Casper TC, Newman J, Borkowski K, Waubant E. Distinct plasma lipids predict axonal injury and multiple sclerosis activity. J Neurol Neurosurg Psychiatry. 2025 Jan 16; 96(2):150-157.
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Kammeyer R, Chapman K, Furniss A, Hsieh E, Fuhlbrigge R, Ogbu EA, Boackle S, Zell J, Nair KV, Borko TL, Cooper JC, Bennett JL, Piquet AL. Blood-based biomarkers of neuronal and glial injury in active major neuropsychiatric systemic lupus erythematosus. Lupus. 2024 Sep; 33(10):1116-1129.
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Kocik VI, Dengler BA, Rizzo JA, Ma Moran M, Willis AM, April MD, Schauer SG. A Narrative Review of Existing and Developing Biomarkers in Acute Traumatic Brain Injury for Potential Military Deployed Use. Mil Med. 2024 May 18; 189(5-6):e1374-e1380.
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Trifilio E, Bottari S, McQuillan LE, Barton DJ, Lamb DG, Robertson C, Rubenstein R, Wang KK, Wagner AK, Williamson JB. Temporal Profile of Serum Neurofilament Light (NF-L) and Heavy (pNF-H) Level Associations With 6-Month Cognitive Performance in Patients With Moderate-Severe Traumatic Brain Injury. J Head Trauma Rehabil. 2024 Nov-Dec 01; 39(6):E470-E480.
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Wang KKW, Barton DJ, McQuillan LE, Kobeissy F, Cai G, Xu H, Yang Z, Trifilio E, Williamson JB, Rubenstein R, Robertson CS, Wagner AK. Parallel Cerebrospinal Fluid and Serum Temporal Profile Assessment of Axonal Injury Biomarkers Neurofilament-Light Chain and Phosphorylated Neurofilament-Heavy Chain: Associations With Patient Outcome in Moderate-Severe Traumatic Brain Injury. J Neurotrauma. 2024 07; 41(13-14):1609-1627.
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