 RNA, Messenger
"RNA, Messenger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
| Descriptor ID |
D012333
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| MeSH Number(s) |
D13.444.735.544
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| Concept/Terms |
mRNA, Polyadenylated- mRNA, Polyadenylated
- RNA, Messenger, Polyadenylated
- Messenger RNA, Polyadenylated
- Polyadenylated Messenger RNA
- RNA, Polyadenylated Messenger
- Polyadenylated mRNA
- Poly(A)+ mRNA
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Below are MeSH descriptors whose meaning is more general than "RNA, Messenger".
Below are MeSH descriptors whose meaning is more specific than "RNA, Messenger".
This graph shows the total number of publications written about "RNA, Messenger" by people in this website by year, and whether "RNA, Messenger" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 35 | 41 | | 1996 | 2 | 42 | 44 | | 1997 | 5 | 42 | 47 | | 1998 | 10 | 48 | 58 | | 1999 | 4 | 39 | 43 | | 2000 | 4 | 48 | 52 | | 2001 | 7 | 53 | 60 | | 2002 | 11 | 70 | 81 | | 2003 | 8 | 76 | 84 | | 2004 | 14 | 64 | 78 | | 2005 | 7 | 69 | 76 | | 2006 | 10 | 78 | 88 | | 2007 | 9 | 67 | 76 | | 2008 | 13 | 57 | 70 | | 2009 | 14 | 51 | 65 | | 2010 | 12 | 52 | 64 | | 2011 | 15 | 51 | 66 | | 2012 | 20 | 53 | 73 | | 2013 | 12 | 48 | 60 | | 2014 | 17 | 45 | 62 | | 2015 | 10 | 66 | 76 | | 2016 | 17 | 50 | 67 | | 2017 | 11 | 50 | 61 | | 2018 | 11 | 41 | 52 | | 2019 | 19 | 24 | 43 | | 2020 | 14 | 41 | 55 | | 2021 | 14 | 26 | 40 | | 2022 | 2 | 60 | 62 | | 2023 | 2 | 38 | 40 | | 2024 | 12 | 23 | 35 | | 2025 | 10 | 9 | 19 |
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Below are the most recent publications written about "RNA, Messenger" by people in Profiles.
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Cheng LY, Ripin N, Cech TR, Parker R. DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs. Nucleic Acids Res. 2025 Sep 23; 53(18).
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Joseph RA, Haley RM, Padilla MS, Ricciardi AS, Yamagata HM, Mitchell MJ. Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair. Nano Lett. 2025 Oct 01; 25(39):14348-14355.
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Gu W, Langlois AWR, Giratallah H, Claw KG, Prasad B, Thummel KE, Tyndale RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacol Res Perspect. 2025 Aug; 13(4):e70149.
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Parks KR, Moodie Z, Allen MA, Yen C, Furch BD, MacPhee KJ, Ozorowski G, Heptinstall J, Hahn WO, Zheng Z, Lu H, Grant S, Domin E, Duff MO, Seese A, Marini-Macouzet C, Ballweber-Fleming L, Lee WH, Cottrell CA, Liguori A, Georgeson E, Alavi N, Kubitz M, Phelps N, Seaton KE, Cohen KW, Anderson MA, Mondal K, Laufer DS, Kublin JG, Ward AB, Hyrien O, De Rosa SC, Himansu S, Leav B, Reuter C, Tomaras GD, Montefiori D, Walsh SR, Frank I, Sobieszczyk ME, Goepfert PA, Stephenson KE, Baden LR, Van Tieu H, Keefer MC, Clark J, Riddler SA, Schief WR, McElrath MJ. Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial. Sci Transl Med. 2025 Jul 30; 17(809):eady6831.
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Martinez A, Stemm-Wolf AJ, Sheridan RM, Taliaferro JM, Pearson CG. The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication. J Cell Biol. 2025 Aug 04; 224(8).
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Witt KC, Dziulko A, An J, Pekovic F, Cheng AX, Liu GY, Lee OV, Turner DJ, Lari A, Gaidt MM, Chavez R, Fattinger SA, Abraham P, Dhaliwal H, Lee AY, Kotov DI, Coscoy L, Glaunsinger BA, Valkov E, Chuong EB, Vance RE. SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity. Nature. 2025 Jul; 643(8074):1372-1380.
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Palo MZ, Ha B, Lapointe CP, Alvarado C, Janetzko J, Carette JE, Puglisi JD, Puglisi EV. Conserved long-range interactions are required for stable folding of orthoflaviviral genomic RNA. Nucleic Acids Res. 2025 Jun 06; 53(11).
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Aunins EA, Phan AT, Alameh MG, Dwivedi G, Cruz-Morales E, Christian DA, Tam Y, Bunkofske ME, Peñafiel AZ, O'Dea KM, Merolle M, Furey C, Scott P, Vonderheide RH, Hensley SE, Kedl RM, Weissman D, Hunter CA. An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses. Sci Immunol. 2025 06 06; 10(108):eads1328.
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Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Lau R, Pitzalis C, Lewis MJ, Holers VM. Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation. Sci Rep. 2025 Jun 04; 15(1):19633.
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Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cortázar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Coban-Akdemir ZH, Jagannathan S. Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay. Cell Genom. 2025 Jul 09; 5(7):100882.
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