 RNA, Messenger
"RNA, Messenger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
| Descriptor ID |
D012333
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| MeSH Number(s) |
D13.444.735.544
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| Concept/Terms |
mRNA, Polyadenylated- mRNA, Polyadenylated
- RNA, Messenger, Polyadenylated
- Messenger RNA, Polyadenylated
- Polyadenylated Messenger RNA
- RNA, Polyadenylated Messenger
- Polyadenylated mRNA
- Poly(A)+ mRNA
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Below are MeSH descriptors whose meaning is more general than "RNA, Messenger".
Below are MeSH descriptors whose meaning is more specific than "RNA, Messenger".
This graph shows the total number of publications written about "RNA, Messenger" by people in this website by year, and whether "RNA, Messenger" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 31 | 37 | | 1996 | 1 | 40 | 41 | | 1997 | 3 | 42 | 45 | | 1998 | 10 | 44 | 54 | | 1999 | 4 | 39 | 43 | | 2000 | 4 | 45 | 49 | | 2001 | 5 | 50 | 55 | | 2002 | 13 | 70 | 83 | | 2003 | 8 | 74 | 82 | | 2004 | 14 | 66 | 80 | | 2005 | 6 | 68 | 74 | | 2006 | 10 | 79 | 89 | | 2007 | 9 | 65 | 74 | | 2008 | 13 | 55 | 68 | | 2009 | 12 | 48 | 60 | | 2010 | 12 | 49 | 61 | | 2011 | 15 | 48 | 63 | | 2012 | 20 | 52 | 72 | | 2013 | 11 | 46 | 57 | | 2014 | 15 | 45 | 60 | | 2015 | 9 | 60 | 69 | | 2016 | 17 | 42 | 59 | | 2017 | 9 | 45 | 54 | | 2018 | 11 | 40 | 51 | | 2019 | 14 | 19 | 33 | | 2020 | 13 | 41 | 54 | | 2021 | 11 | 21 | 32 | | 2022 | 2 | 51 | 53 | | 2023 | 1 | 33 | 34 | | 2024 | 5 | 14 | 19 | | 2025 | 3 | 4 | 7 |
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Below are the most recent publications written about "RNA, Messenger" by people in Profiles.
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Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Lau R, Pitzalis C, Lewis MJ, Holers VM. Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation. Sci Rep. 2025 Jun 04; 15(1):19633.
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Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, Doymaz A, Wu J, Anderson KS, Gazzo A, Pareja F, Yamaguchi TN, Vougiouklakis T, Ahmed-Seghir S, Steinberg P, Neiman-Golden A, Azeroglu B, Gomez-Aguilar J, da Silva EM, Hussain S, Higginson D, Boutros PC, Riaz N, Reis-Filho JS, Powell SN, Sfeir A. RNA transcripts serve as a template for double-strand break repair in human cells. Nat Commun. 2025 May 10; 16(1):4349.
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Forouzanfar F, Moreno DF, Plassard D, Furst A, Oliveira KA, Reina-San-Martin B, Tora L, Molina N, Mendoza M. Gene-specific transcript buffering revealed by perturbation of coactivator complexes. Sci Adv. 2025 Mar 21; 11(12):eadr1492.
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Du X, Nakanishi H, Yamada T, Sin Y, Minegishi K, Motohashi N, Aoki Y, Itaka K. Polyplex Nanomicelle-Mediated Pgc-1a4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice. Adv Sci (Weinh). 2025 Apr; 12(16):e2409065.
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Loughran G, Andreev DE, Terenin IM, Namy O, Mikl M, Yordanova MM, McManus CJ, Firth AE, Atkins JF, Fraser CS, Ignatova Z, Iwasaki S, Kufel J, Larsson O, Leidel SA, Mankin AS, Mariotti M, Tanenbaum ME, Topisirovic I, V?zquez-Laslop N, Viero G, Caliskan N, Chen Y, Clark PL, Dinman JD, Farabaugh PJ, Gilbert WV, Ivanov P, Kieft JS, M?hlemann O, Sachs MS, Shatsky IN, Sonenberg N, Steckelberg AL, Willis AE, Woodside MT, Valasek LS, Dmitriev SE, Baranov PV. Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR). Nat Struct Mol Biol. 2025 Mar; 32(3):418-430.
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Bresalier RS, Shaheen NJ, Hernandez M, Buttar N, Marcon N, Wani S, Muthusamy R, Falk G, Johnson TT, Yan P, Huo X, Castille TA, Della'Zanna G, Richmond E, Jack Lee J, Brown P, Souza R. Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation. Dig Dis Sci. 2025 Mar; 70(3):1034-1042.
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Sherlock ME, Langeberg CJ, Segar KE, Kieft JS. A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions. Cell Rep. 2025 02 25; 44(2):115236.
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Gentry RC, Ide NA, Comunale VM, Hartwick EW, Kinz-Thompson CD, Gonzalez RL. The mechanism of mRNA cap recognition. Nature. 2025 Jan; 637(8046):736-743.
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Sajek MP, Bilodeau DY, Beer MA, Horton E, Miyamoto Y, Velle KB, Eckmann L, Fritz-Laylin L, Rissland OS, Mukherjee N. Evolutionary dynamics of polyadenylation signals and their recognition strategies in protists. Genome Res. 2024 Oct 29; 34(10):1570-1581.
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Welle TM, Rajgor D, Kareemo DJ, Garcia JD, Zych SM, Wolfe SE, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. EMBO Rep. 2024 Nov; 25(11):5141-5168.
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