RNA, Messenger
"RNA, Messenger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
| Descriptor ID |
D012333
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| MeSH Number(s) |
D13.444.735.544
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| Concept/Terms |
mRNA, Polyadenylated- mRNA, Polyadenylated
- RNA, Messenger, Polyadenylated
- Messenger RNA, Polyadenylated
- Polyadenylated Messenger RNA
- RNA, Polyadenylated Messenger
- Polyadenylated mRNA
- Poly(A)+ mRNA
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Below are MeSH descriptors whose meaning is more general than "RNA, Messenger".
Below are MeSH descriptors whose meaning is more specific than "RNA, Messenger".
This graph shows the total number of publications written about "RNA, Messenger" by people in this website by year, and whether "RNA, Messenger" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 41 | 42 | | 1997 | 5 | 39 | 44 | | 1998 | 10 | 47 | 57 | | 1999 | 5 | 39 | 44 | | 2000 | 4 | 50 | 54 | | 2001 | 7 | 53 | 60 | | 2002 | 10 | 70 | 80 | | 2003 | 7 | 76 | 83 | | 2004 | 14 | 66 | 80 | | 2005 | 8 | 71 | 79 | | 2006 | 10 | 85 | 95 | | 2007 | 9 | 68 | 77 | | 2008 | 13 | 57 | 70 | | 2009 | 14 | 51 | 65 | | 2010 | 12 | 52 | 64 | | 2011 | 14 | 51 | 65 | | 2012 | 19 | 55 | 74 | | 2013 | 12 | 52 | 64 | | 2014 | 17 | 47 | 64 | | 2015 | 10 | 66 | 76 | | 2016 | 17 | 56 | 73 | | 2017 | 11 | 50 | 61 | | 2018 | 11 | 43 | 54 | | 2019 | 19 | 23 | 42 | | 2020 | 14 | 40 | 54 | | 2021 | 12 | 27 | 39 | | 2022 | 1 | 58 | 59 | | 2023 | 2 | 38 | 40 | | 2024 | 11 | 23 | 34 | | 2025 | 14 | 13 | 27 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA, Messenger" by people in Profiles.
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Han EL, Kim D, Murray AM, Mrksich K, Hamilton AG, Tang S, Yoo S, Zhu AT, Tong ER, Palanki R, Hall ML, Bedingfield SK, Mitchell MJ. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS Nano. 2026 Feb 03; 20(4):3807-3820.
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Moffatt C, Arora A, Vaeth KF, Guzman BB, Bhardwaj G, Hoelscher A, Gifford LB, Russ HA, Dominguez D, Taliaferro JM. TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability. EMBO J. 2026 Feb; 45(3):692-721.
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Saiduzzaman SM, Xu R, Sampad MJN, Hoffman RN, Seiler ST, Brail Q, Yurevych V, Walker ZJ, Wells TN, Ong EM, Yuzvinsky TD, Hawkins AR, Salama SR, Teodorescu M, Haussler D, Schmidt H. Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health. Sci Rep. 2025 Dec 12; 15(1):45806.
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Necker-Brown A, Mostafa MM, Georgescu A, Thorne AJ, Chandramohan P, Kooi C, Kalyanaraman K, Gao A, Bansal A, Sasse SK, Gerber AN, Leigh R, Newton R. Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-?B. PLoS One. 2025; 20(12):e0329244.
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O'Brien EM, Tylek T, Geisler HC, Mukalel AJ, Whitaker RC, Sung S, Binder-Markey BI, Weissman D, Mitchell MJ, Spiller KL. Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries. Biomaterials. 2026 May; 328:123869.
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Bar J, Cai MH, Choi YC, Baijal S, Zhao W, Liede A, Vasilopoulos A, Roberts-Rapp L, Jiang F, Simmons A, Ratajczak C, Lu S, Ansell PJ, Camidge DR. Prevalence, molecular characterization, and prognosis of c-Met protein overexpression in a real-world cohort of patients with non-squamous non-small cell lung cancer. Acta Oncol. 2025 11 18; 64:1544-1553.
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Coleman HJ, Rauch A, Langsfeld E, Anderson K, Parlikar U, Funke HH, Garcea RL, Randolph TW. Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition. J Pharm Sci. 2026 Feb; 115(2):104066.
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Henrich IC, Billingsley MM, Jain K, Mondal S, Quick LN, Young R, Nguyen N, Oliveira AM, Blobel GA, Mitchell MJ, Chou MM. Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma. Mol Cancer Ther. 2025 Nov 03; 24(11):1802-1814.
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Shenasa H, Fong N, Erickson B, Iosub IA, Ule J, Bentley DL. CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing. Proc Natl Acad Sci U S A. 2025 Oct 07; 122(40):e2504034122.
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Cheng LY, Ripin N, Cech TR, Parker R. DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs. Nucleic Acids Res. 2025 Sep 23; 53(18).
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