 RNA, Messenger
"RNA, Messenger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
| Descriptor ID |
D012333
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| MeSH Number(s) |
D13.444.735.544
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| Concept/Terms |
mRNA, Polyadenylated- mRNA, Polyadenylated
- RNA, Messenger, Polyadenylated
- Messenger RNA, Polyadenylated
- Polyadenylated Messenger RNA
- RNA, Polyadenylated Messenger
- Polyadenylated mRNA
- Poly(A)+ mRNA
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Below are MeSH descriptors whose meaning is more general than "RNA, Messenger".
Below are MeSH descriptors whose meaning is more specific than "RNA, Messenger".
This graph shows the total number of publications written about "RNA, Messenger" by people in this website by year, and whether "RNA, Messenger" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 40 | 41 | | 1997 | 5 | 38 | 43 | | 1998 | 9 | 47 | 56 | | 1999 | 5 | 37 | 42 | | 2000 | 3 | 50 | 53 | | 2001 | 7 | 53 | 60 | | 2002 | 10 | 68 | 78 | | 2003 | 7 | 76 | 83 | | 2004 | 14 | 67 | 81 | | 2005 | 8 | 70 | 78 | | 2006 | 10 | 85 | 95 | | 2007 | 9 | 70 | 79 | | 2008 | 14 | 56 | 70 | | 2009 | 14 | 51 | 65 | | 2010 | 12 | 51 | 63 | | 2011 | 14 | 52 | 66 | | 2012 | 19 | 56 | 75 | | 2013 | 10 | 51 | 61 | | 2014 | 17 | 47 | 64 | | 2015 | 11 | 67 | 78 | | 2016 | 17 | 55 | 72 | | 2017 | 12 | 52 | 64 | | 2018 | 11 | 45 | 56 | | 2019 | 19 | 23 | 42 | | 2020 | 14 | 39 | 53 | | 2021 | 12 | 28 | 40 | | 2022 | 1 | 57 | 58 | | 2023 | 2 | 41 | 43 | | 2024 | 14 | 24 | 38 | | 2025 | 18 | 14 | 32 | | 2026 | 14 | 6 | 20 |
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Below are the most recent publications written about "RNA, Messenger" by people in Profiles.
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Safford HC, Geisler HC, Thatte AS, Liao KC, Poirier A, Padilla M, Yamagata HM, Agrawal A, Murray AM, Hamilton AG, Swingle KL, Fitzgerald E, Chalom O, Wan Y, Mitchell MJ. Enhancing Lipid Nanoparticle-Mediated Circular RNA and mRNA Expression in the Placenta through Inhibition of IFNAR-JAK-STAT Signaling. Nano Lett. 2026 08 26; 26(33):10980-10991.
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Macedo de Vasconcelos L, Ripin N, Parker R. Zinc increases stress granule formation by promoting RNA condensation. Cell Rep. 2026 Sep 22; 45(9):117870.
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Wang S, Zhong Y, Wang C, Tian M, Bennett JL, Bliss-Moreau E, Xue Y, Yu C, Hou X, Zheng YY, Li H, Liu Z, Cao D, Kang DD, Deng B, Dong Y. Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics. Proc Natl Acad Sci U S A. 2026 Aug 18; 123(33):e2538147123.
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Padilla MS, Li JJ, Zhang Q, Patwari K, Shi S, Yamagata HM, Joseph RA, Hymms BN, Teerdhala SV, Fitzgerald E, Chalom OZ, Gupta K, Alameh MG, Weissman D, Le AD, Mitchell MJ. Lipid Nanoparticle Co-Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy. Adv Mater. 2026 Aug; 38(47):e73721.
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Zeng Y, Xu J, Wang J, Xue L, Liu J, Geisler HC, Ma X, Melamed JR, Shi Q, Padilla MS, Luo Z, Zhu J, Thatte AS, Figueroa-Espada CG, Ang MJY, Murray AM, Yamagata HM, Kim D, Metzloff AE, Weissman D, Mitchell MJ. mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity. Proc Natl Acad Sci U S A. 2026 Jul 14; 123(28):e2525718123.
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Gupta A, Struba AZ, Madhavan S, Strayer E, Beaudoin JD. NaP-TRAP: A Versatile and Accessible Workflow to Dissect Principles of Translational Regulation and mRNA Stability. Curr Protoc. 2026 Jul; 6(7):e70417.
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Van Gundy T, Schneider C, Ebmeier CC, Chambers GZ, Cramer NA, Chambers KM, Drecktrah D, Hyde JA, Skare JT, Marconi RT, Samuels DS, Lybecker MC. Identification of proteins exhibiting in vitro RNA chaperone activity through gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi. RNA Biol. 2026 Dec; 23(1):1-23.
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Janssen WJ, Lapinig M, Wynn E, Aguilar M, Mould KJ, Hume PS, McClendon JD, Lee FFY, Moore CM, Alper S. Alternative splicing of toll-like receptor pathway mRNAs in lung immune cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2026 Aug 01; 331(2):L155-L164.
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Han X, Xu Y, Ricciardi AS, Xu J, Xiang Y, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Reker D, Weissman D, Mitchell MJ. Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Proc Natl Acad Sci U S A. 2026 Jun 02; 123(22):e2528144123.
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Zaganelli S, Meehl JB, Abrisch RG, Voeltz GK. Nuclear envelope budding enables export of large transcripts in muscle cells. Cell. 2026 May 28; 189(11):3398-3412.e13.
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