 Complement System Proteins
"Complement System Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
| Descriptor ID |
D003165
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| MeSH Number(s) |
D12.776.124.486.274
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| Concept/Terms |
Complement System Proteins- Complement System Proteins
- Proteins, Complement System
- Complement Protein
- Protein, Complement
- Complement Proteins
- Proteins, Complement
- Complement
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Below are MeSH descriptors whose meaning is more general than "Complement System Proteins".
Below are MeSH descriptors whose meaning is more specific than "Complement System Proteins".
This graph shows the total number of publications written about "Complement System Proteins" by people in this website by year, and whether "Complement System Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 3 | 0 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 1 | 3 | | 2008 | 3 | 0 | 3 | | 2009 | 2 | 1 | 3 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 1 | 4 | | 2012 | 1 | 5 | 6 | | 2013 | 7 | 2 | 9 | | 2014 | 4 | 2 | 6 | | 2015 | 1 | 0 | 1 | | 2016 | 8 | 1 | 9 | | 2017 | 4 | 5 | 9 | | 2018 | 9 | 2 | 11 | | 2019 | 8 | 4 | 12 | | 2020 | 7 | 6 | 13 | | 2021 | 9 | 3 | 12 | | 2022 | 4 | 6 | 10 | | 2023 | 4 | 12 | 16 | | 2024 | 0 | 4 | 4 | | 2025 | 12 | 0 | 12 | | 2026 | 3 | 0 | 3 |
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Below are the most recent publications written about "Complement System Proteins" by people in Profiles.
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Jacques S, Gaikwad H, Pillatzke J, Moghimi SM, Simberg D. Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor. Chem Commun (Camb). 2026 Jul 03; 62(51):12859-12862.
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Shadid A, Rich HE, Hok KD, Doursout MF, Restrepo MI, Banda NK, Gunamalai L, Shivshankar P. Comprehensive Prediction Analysis of Novel Noncoding Regulatory Variants Identified in the MicroRNA Binding Regions in Complement System Genes. Int J Mol Sci. 2026 Jun 30; 27(13).
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Holers VM. The evolving landscape of complement therapeutics in rheumatology. Ann Rheum Dis. 2026 Jun; 85(6):969-983.
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Thurman JM. Advances in Complement Research: from Pathophysiology to Precision Medicine. Physiology (Bethesda). 2026 09 01; 41(5):0.
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E de Carlo Forest T, Marin AI, Gill Z, Gnanaraj R, Patnaik JL, Poppelaars F, Lynch AM, Palestine AG, Mathias MT, Manoharan N, Frazer-Abel AA, Holers VM, Mandava N. Association between systemic complement levels and choroidal thickness in advanced non-neovascular age-related macular degeneration. Sci Rep. 2025 Dec 06; 16(1):1442.
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Rizk DV, Dixon BP, Chan M, Cook HT, Frazer-Abel A, Tang SCW. Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics. Clin J Am Soc Nephrol. 2026 Jul 01; 21(7):1245-1257.
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Mallah K, Krieg C, Hatchell D, Hamouda N, Roof T, Walterhouse S, Toutonji A, Borucki D, Couch C, Hardiman G, Kobeissy F, Guglietta S, Tomlinson S. Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury. Signal Transduct Target Ther. 2025 11 20; 10(1):378.
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Hok KD, Rich HE, Shadid A, Gunamalai L, Weng-Mills T, Thandavarayan RA, Banda NK, Doursout MF, Restrepo MI, Shivshankar P. Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy. Int J Mol Sci. 2025 Oct 12; 26(20).
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Hu X, Webb-Robertson BM, Parikh HM, Nakayasu ES, Onengut-Gumuscu S, Chen WM, Frazer-Abel A, Metz TO, Rich SS, Rewers MJ, Manichaikul A. Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D. Commun Biol. 2025 Sep 26; 8(1):1366.
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Liu F, Wawersik S, Tomlinson S, Thurman JM, Holers VM. Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies. J Immunol. 2025 Sep 01; 214(9):2138-2149.
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