 Complement System Proteins
"Complement System Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
| Descriptor ID |
D003165
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| MeSH Number(s) |
D12.776.124.486.274
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| Concept/Terms |
Complement System Proteins- Complement System Proteins
- Proteins, Complement System
- Complement Protein
- Protein, Complement
- Complement Proteins
- Proteins, Complement
- Complement
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Below are MeSH descriptors whose meaning is more general than "Complement System Proteins".
Below are MeSH descriptors whose meaning is more specific than "Complement System Proteins".
This graph shows the total number of publications written about "Complement System Proteins" by people in this website by year, and whether "Complement System Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 3 | 0 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 1 | 3 | | 2008 | 3 | 0 | 3 | | 2009 | 2 | 1 | 3 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 1 | 4 | | 2012 | 0 | 5 | 5 | | 2013 | 7 | 2 | 9 | | 2014 | 4 | 1 | 5 | | 2015 | 1 | 0 | 1 | | 2016 | 8 | 1 | 9 | | 2017 | 4 | 4 | 8 | | 2018 | 8 | 2 | 10 | | 2019 | 8 | 4 | 12 | | 2020 | 6 | 5 | 11 | | 2021 | 9 | 3 | 12 | | 2022 | 4 | 6 | 10 | | 2023 | 4 | 10 | 14 | | 2024 | 0 | 4 | 4 | | 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "Complement System Proteins" by people in Profiles.
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Prasad RR, Kumar S, Zhang H, Li M, Hu CJ, Riddle S, McKeon BA, Frid MG, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Tuder RM, Stenmark KR. An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension. JCI Insight. 2025 Feb 13; 10(6).
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Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP, Raychaudhuri S, Dwyer DF, Jonsson AH, Brenner MB. Granzyme K activates the entire complement cascade. Nature. 2025 May; 641(8061):211-221.
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Nandakumar V, Braun KMP, Willrich MAV. Challenges for complement functional assays in the clinical laboratory: From test validation to clinical interpretation. J Immunol Methods. 2025 Feb; 537:113824.
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Williams J, Iheagwam FN, Maroney SP, Schmitt LR, Brown RD, Krafsur GM, Frid MG, McCabe MC, Gandjeva A, Williams KJ, Luyendyk JP, Saviola AJ, Tuder RM, Stenmark K, Hansen KC. A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation. Am J Physiol Cell Physiol. 2024 Dec 01; 327(6):C1666-C1680.
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Li Y, Saba L, Scheinman RI, Banda NK, Holers M, Monte A, Dylla L, Moghimi SM, Simberg D. Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts. ACS Nano. 2024 10 22; 18(42):28649-28658.
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Mickael C, Jordan M, Posey JN, Tuder RM, Nozik ES, Thurman JM, Stenmark KR, Graham BB, Delaney CA. Activation of platelets and the complement system in mice with Schistosoma-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2024 Nov 01; 327(5):L661-L668.
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Vivarelli M, Barratt J, Beck LH, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH. The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2024 Sep; 106(3):369-391.
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Li Y, Moein Moghimi S, Simberg D. Complement-dependent uptake of nanoparticles by blood phagocytes: brief overview and perspective. Curr Opin Biotechnol. 2024 02; 85:103044.
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Haroon HB, Dhillon E, Farhangrazi ZS, Trohopoulos PN, Simberg D, Moghimi SM. Activation of the complement system by nanoparticles and strategies for complement inhibition. Eur J Pharm Biopharm. 2023 Dec; 193:227-240.
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Petr V, Thurman JM. The role of complement in kidney disease. Nat Rev Nephrol. 2023 12; 19(12):771-787.
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