 Lymphocyte Activation
"Lymphocyte Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
| Descriptor ID |
D008213
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| MeSH Number(s) |
E01.370.225.812.482 E05.200.812.482 E05.478.594.530 G12.450.050.400.545 G12.565
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| Concept/Terms |
Lymphocyte Activation- Lymphocyte Activation
- Activation, Lymphocyte
- Blast Transformation
- Blastogenesis
- Lymphocyte Stimulation
- Stimulation, Lymphocyte
- Lymphocyte Transformation
- Transformation, Lymphoblast
- Lymphoblast Transformation
- Transformation, Blast
- Transformation, Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Activation".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Activation".
This graph shows the total number of publications written about "Lymphocyte Activation" by people in this website by year, and whether "Lymphocyte Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 10 | 13 | | 1996 | 6 | 7 | 13 | | 1997 | 6 | 11 | 17 | | 1998 | 10 | 22 | 32 | | 1999 | 11 | 9 | 20 | | 2000 | 12 | 13 | 25 | | 2001 | 6 | 13 | 19 | | 2002 | 11 | 14 | 25 | | 2003 | 9 | 22 | 31 | | 2004 | 8 | 17 | 25 | | 2005 | 11 | 12 | 23 | | 2006 | 7 | 19 | 26 | | 2007 | 7 | 19 | 26 | | 2008 | 13 | 14 | 27 | | 2009 | 6 | 22 | 28 | | 2010 | 5 | 15 | 20 | | 2011 | 4 | 16 | 20 | | 2012 | 6 | 26 | 32 | | 2013 | 7 | 16 | 23 | | 2014 | 8 | 23 | 31 | | 2015 | 4 | 16 | 20 | | 2016 | 3 | 14 | 17 | | 2017 | 4 | 25 | 29 | | 2018 | 4 | 14 | 18 | | 2019 | 0 | 19 | 19 | | 2020 | 4 | 8 | 12 | | 2021 | 4 | 15 | 19 | | 2022 | 2 | 7 | 9 | | 2024 | 1 | 4 | 5 | | 2025 | 2 | 9 | 11 |
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Below are the most recent publications written about "Lymphocyte Activation" by people in Profiles.
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Albert GK, Cao P, Davila E. Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity. Front Immunol. 2025; 16:1617773.
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Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025 Sep; 645(8080):496-506.
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Mann BT, Sanz M, Clohosey ML, Langlands K, Chitrakar A, Moreno-Soriano C, Vitalle J, Iannone MA, Ruiz-Mateos E, Deleage C, Siegel M, Soriano-Sarabia N. Dual role of circulating and mucosal Vd1 T cells in the control of and contribution to persistent HIV-1 infection. Nat Commun. 2025 Jul 01; 16(1):5817.
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van der Heide V, Laghlali G, Davenport B, Cubitt B, Roudko V, Choo D, Jhun K, Humblin E, Vaidya A, Angeliadis K, Dawson T, Furtado G, Kamphorst AO, Schotsaert M, Ahmed R, de la Torre JC, Homann D. Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8+ T cells. Immunity. 2025 Jul 08; 58(7):1742-1761.e14.
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Peddaboina C, Iannucci J, Tobin RP, Shapiro LA, Newell Rogers MK. Autophagy Differentially Influences Toll-like Receptor 9 and B Cell-Receptor-Mediated B Cell Expansion, Expression of Major Histocompatibility Class II Proteins, and Antigenic Peptide Presentation. Int J Mol Sci. 2025 Jun 24; 26(13).
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Lanzar ZR, Aldridge DL, Jayaraman B, Haskins B, Howard CA, Arana K, Bunkofske ME, Mulka K, Pardy RD, Byerly J, Striepen B, Lupardus P, Hunter CA. De-coupling immune parameters and toxicity associated with IL-12 agonism. Cell Rep. 2025 Jun 24; 44(6):115840.
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Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 May 22; 10(10).
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Nicholas CA, Tensun FA, Evans SA, Toole KP, Prendergast JE, Broncucia H, Hesselberth JR, Gottlieb PA, Wells KL, Smith MJ. Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes. Cell Rep. 2025 Apr 22; 44(4):115425.
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Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E, Hancock B, Dominguez ST, Gurra MG, Gurajala S, Jonsson AH, Seifert JA, Feser ML, Norris JM, Cao Y, Apruzzese W, Bridges SL, Bykerk VP, Goodman S, Donlin LT, Firestein GS, Bathon JM, Hughes LB, Filer A, Pitzalis C, Anolik JH, Moreland L, Hacohen N, Guthridge JM, James JA, Cuda CM, Perlman H, Brenner MB, Raychaudhuri S, Sparks JA, Holers VM, Deane KD, Lederer J, Rao DA, Zhang F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. J Clin Invest. 2025 Mar 17; 135(6).
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Pham-Danis C, Novak AJ, Danis E, McClellan SM, Leach L, Yarnell MC, Ebmeier CC, Tasian SK, Kohler ME. Restoration of LAT activity improves CAR T?cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia. Cancer Cell. 2025 Mar 10; 43(3):482-502.e9.
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