 Quinolinic Acid
"Quinolinic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
| Descriptor ID |
D017378
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| MeSH Number(s) |
D03.383.725.822.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinolinic Acid".
Below are MeSH descriptors whose meaning is more specific than "Quinolinic Acid".
This graph shows the total number of publications written about "Quinolinic Acid" by people in this website by year, and whether "Quinolinic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Quinolinic Acid" by people in Profiles.
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Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lle? A, Blesa R, Fortea J, D'Alessandro A, Costello JC, Sullivan KD, Espinosa JM. Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nat Commun. 2019 10 18; 10(1):4766.
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Coccaro EF, Lee R, Fanning JR, Fuchs D, Goiny M, Erhardt S, Christensen K, Brundin L, Coussons-Read M. Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. Psychoneuroendocrinology. 2016 09; 71:189-96.
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Goodman SI. Development of pathogenic concepts in glutaryl-CoA dehydrogenase deficiency: the challenge. J Inherit Metab Dis. 2004; 27(6):801-3.
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Bjugstad KB, Zawada WM, Goodman S, Freed CR. IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures. J Inherit Metab Dis. 2001 Nov; 24(6):631-47.
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Look MP, Altfeld M, Kreuzer KA, Riezler R, Stabler SP, Allen RH, Sauerbruch T, Rockstroh JK. Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease. AIDS Res Hum Retroviruses. 2000 Sep 01; 16(13):1215-21.
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