Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
532
1.390
Why?
Xenograft Model Antitumor Assays
22
2025
928
1.260
Why?
Antineoplastic Agents
19
2025
2192
1.230
Why?
Triple Negative Breast Neoplasms
5
2020
215
1.220
Why?
Protein Kinase Inhibitors
15
2020
968
1.190
Why?
Colorectal Neoplasms
11
2018
844
0.920
Why?
Proto-Oncogene Proteins
10
2018
623
0.920
Why?
Azepines
4
2020
107
0.820
Why?
Piperazines
4
2020
380
0.800
Why?
Quinoxalines
2
2020
65
0.780
Why?
Melanoma
10
2018
760
0.750
Why?
Pyrazoles
4
2018
509
0.730
Why?
Gene Expression Regulation, Neoplastic
9
2020
1455
0.710
Why?
Mice, Nude
16
2020
682
0.650
Why?
Cell Proliferation
22
2025
2494
0.640
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
154
0.600
Why?
beta Catenin
2
2020
252
0.590
Why?
Enoyl-CoA Hydratase
1
2018
12
0.580
Why?
Cell Line, Tumor
25
2025
3539
0.530
Why?
DNA-Binding Proteins
8
2015
1497
0.520
Why?
Benzimidazoles
4
2013
190
0.490
Why?
Tumor Microenvironment
1
2020
732
0.480
Why?
Mutation
11
2018
4085
0.460
Why?
Cardiomyopathy, Dilated
1
2018
359
0.460
Why?
Tumor Suppressor Proteins
2
2015
321
0.450
Why?
Tumor Suppressor Protein p53
4
2016
529
0.440
Why?
ras Proteins
3
2013
150
0.410
Why?
Apoptosis
14
2025
2430
0.400
Why?
Pyrazines
5
2013
92
0.390
Why?
Genomics
1
2018
833
0.390
Why?
Proto-Oncogene Proteins B-raf
4
2018
225
0.370
Why?
Oncogene Proteins, Fusion
3
2018
210
0.350
Why?
Drug Design
1
2012
173
0.340
Why?
Mice
22
2025
18329
0.320
Why?
Biomarkers, Tumor
3
2017
1313
0.320
Why?
Prolactin
7
2004
89
0.320
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
128
0.320
Why?
Histone Deacetylase Inhibitors
3
2022
220
0.310
Why?
Nuclear Proteins
1
2015
748
0.310
Why?
Aurora Kinase A
4
2020
62
0.300
Why?
Drug Resistance, Neoplasm
8
2020
881
0.290
Why?
Animals
45
2025
38030
0.280
Why?
Cell Transformation, Neoplastic
4
2013
339
0.270
Why?
Pituitary Gland
7
2003
148
0.260
Why?
Imidazoles
4
2013
254
0.260
Why?
Neoplasms
4
2022
2870
0.250
Why?
Hydroxamic Acids
3
2011
94
0.240
Why?
Ethanol
11
1997
625
0.230
Why?
Gene Expression Profiling
6
2018
1782
0.230
Why?
Exome
2
2017
227
0.230
Why?
Protein Synthesis Inhibitors
1
2025
48
0.220
Why?
Ubiquitin-Activating Enzymes
2
2016
20
0.220
Why?
Transcription Factors
4
2011
1739
0.210
Why?
Pyrimidinones
2
2015
126
0.210
Why?
Breast Neoplasms
3
2012
2447
0.200
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1953
0.200
Why?
Protein Biosynthesis
2
2025
458
0.200
Why?
Receptor, IGF Type 1
3
2013
64
0.200
Why?
Pyridones
2
2015
198
0.200
Why?
Hematologic Neoplasms
1
2025
161
0.190
Why?
Hypothalamus
12
1997
153
0.180
Why?
Cell Cycle Proteins
3
2018
628
0.180
Why?
Humans
45
2025
144261
0.180
Why?
Immunoblotting
5
2015
300
0.180
Why?
Tumor Cells, Cultured
3
2020
919
0.170
Why?
Drug Synergism
4
2018
357
0.170
Why?
c-Mer Tyrosine Kinase
2
2018
37
0.170
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
44
0.160
Why?
Benzoxazoles
1
2020
20
0.160
Why?
Transcription, Genetic
4
2013
1495
0.160
Why?
Breast
3
2018
157
0.160
Why?
Boronic Acids
2
2011
37
0.160
Why?
Growth Hormone
3
1997
92
0.150
Why?
Signal Transduction
10
2018
5221
0.150
Why?
Adenine
2
2020
339
0.150
Why?
eIF-2 Kinase
1
2019
29
0.150
Why?
Female
27
2020
77976
0.150
Why?
Wnt Signaling Pathway
2
2019
210
0.150
Why?
Sequence Analysis, RNA
2
2018
442
0.150
Why?
Epithelial Cells
4
2011
1125
0.150
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
253
0.150
Why?
Phosphorylation
6
2025
1732
0.140
Why?
Breast Neoplasms, Male
1
2018
29
0.140
Why?
Cell Cycle
7
2018
596
0.140
Why?
Linkage Disequilibrium
1
2018
246
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
70
0.140
Why?
Septins
1
2018
43
0.140
Why?
Cytochrome P-450 Enzyme System
1
2018
162
0.130
Why?
Mice, Inbred BALB C
1
2020
1253
0.130
Why?
Drug Therapy, Combination
1
2020
1044
0.130
Why?
Cytoskeleton
1
2018
195
0.130
Why?
Genetics, Population
1
2018
214
0.130
Why?
Neurofibromin 1
1
2017
26
0.130
Why?
Somatostatin
1
1997
51
0.130
Why?
Gonadotropin-Releasing Hormone
8
1993
212
0.130
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Sexual Maturation
1
1997
51
0.130
Why?
Proto-Oncogene Proteins c-kit
1
2017
72
0.130
Why?
RNA Splicing Factors
1
2017
64
0.130
Why?
Testis
2
1997
163
0.130
Why?
Inhibitory Concentration 50
2
2016
91
0.120
Why?
Cyclopentanes
1
2016
20
0.120
Why?
Proto-Oncogene Proteins c-ret
1
2017
40
0.120
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
125
0.120
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
145
0.120
Why?
Mucous Membrane
1
2017
127
0.120
Why?
Genes, erbB-1
1
2016
21
0.120
Why?
Gene Regulatory Networks
1
2018
318
0.120
Why?
Oligonucleotide Array Sequence Analysis
3
2015
758
0.120
Why?
Education, Graduate
1
2015
36
0.110
Why?
HT29 Cells
2
2018
37
0.110
Why?
Skin Neoplasms
2
2013
847
0.110
Why?
RNA, Messenger
10
2003
2829
0.110
Why?
Peptides, Cyclic
1
1997
275
0.110
Why?
Drug Discovery
1
2016
154
0.110
Why?
Tumor Protein p73
1
2015
18
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
292
0.110
Why?
Neoplasm Invasiveness
3
2018
508
0.110
Why?
Phosphoproteins
1
2017
343
0.110
Why?
Proteasome Endopeptidase Complex
2
2013
159
0.110
Why?
Luteinizing Hormone
8
1993
190
0.110
Why?
Cluster Analysis
2
2012
519
0.100
Why?
Computational Biology
2
2016
680
0.100
Why?
Case-Control Studies
2
2018
3592
0.100
Why?
Protein Kinases
1
2015
315
0.100
Why?
Genotype
1
2018
1833
0.100
Why?
Testosterone
2
1997
419
0.100
Why?
Protein-Tyrosine Kinases
1
2017
433
0.100
Why?
Receptor, Insulin
1
2013
94
0.100
Why?
Phenotype
3
2018
3157
0.100
Why?
Cell Survival
4
2019
1098
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
17
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.100
Why?
Aurora Kinases
1
2012
28
0.100
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
73
0.090
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.090
Why?
BRCA1 Protein
1
2013
81
0.090
Why?
Alcohol Oxidoreductases
1
2013
62
0.090
Why?
Rats
21
2004
5592
0.090
Why?
Genes, p53
1
2012
67
0.090
Why?
MicroRNAs
1
2018
700
0.090
Why?
Cyclosporine
1
2013
265
0.090
Why?
Positron-Emission Tomography
2
2011
323
0.090
Why?
Mitochondria
1
2018
983
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
75
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
191
0.090
Why?
Ubiquitin-Protein Ligases
1
2013
192
0.080
Why?
TOR Serine-Threonine Kinases
1
2014
449
0.080
Why?
Proteasome Inhibitors
1
2011
40
0.080
Why?
Receptor Protein-Tyrosine Kinases
1
2013
230
0.080
Why?
Mammary Glands, Human
1
2011
67
0.080
Why?
Polymorphism, Single Nucleotide
1
2018
2143
0.080
Why?
Transcriptional Activation
2
2003
382
0.080
Why?
Cytoplasm
1
2011
269
0.080
Why?
Protease Inhibitors
1
2011
102
0.080
Why?
Recombinant Fusion Proteins
2
2011
674
0.080
Why?
Cell Movement
3
2011
965
0.080
Why?
Cellular Senescence
1
2012
226
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Ki-67 Antigen
1
2010
117
0.080
Why?
Neoplasm Transplantation
3
2016
251
0.080
Why?
Capillary Permeability
1
2010
134
0.080
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
74
0.070
Why?
Gastrointestinal Neoplasms
1
2009
70
0.070
Why?
Adenocarcinoma
1
2016
927
0.070
Why?
Cell Line
4
2012
2879
0.070
Why?
Quinazolines
1
2009
266
0.070
Why?
Promoter Regions, Genetic
3
2004
1255
0.070
Why?
Peptide Fragments
1
2011
698
0.070
Why?
Carcinoma, Hepatocellular
1
2011
370
0.060
Why?
Pituitary Gland, Anterior
4
1992
37
0.060
Why?
Enzyme Inhibitors
3
2013
824
0.060
Why?
Algorithms
2
2015
1834
0.060
Why?
Drug Delivery Systems
1
2010
379
0.060
Why?
Prognosis
2
2017
4278
0.060
Why?
Colonic Neoplasms
1
2009
259
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
26
0.060
Why?
Reproducibility of Results
2
2010
3403
0.060
Why?
Disease Models, Animal
2
2014
4556
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
18
0.060
Why?
Rats, Inbred Strains
12
1992
321
0.060
Why?
Transplantation, Heterologous
2
2016
193
0.050
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.050
Why?
Proto-Oncogene Proteins c-jun
1
2004
55
0.050
Why?
Gene Expression Regulation
2
2004
2603
0.050
Why?
Proto-Oncogene Proteins c-myc
1
2025
167
0.050
Why?
Transfection
2
2003
938
0.050
Why?
Male
25
2020
72035
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
549
0.050
Why?
Transcription Factor Pit-1
1
2003
26
0.050
Why?
Suppression, Genetic
1
2003
24
0.050
Why?
Mesoderm
1
2004
150
0.050
Why?
Genes, Dominant
1
2003
101
0.050
Why?
Disease Progression
3
2018
2840
0.050
Why?
Pancreatic Neoplasms
1
2011
918
0.050
Why?
Lung Neoplasms
1
2016
2637
0.050
Why?
Histone Deacetylase 1
1
2022
23
0.050
Why?
Caspase 3
2
2013
238
0.040
Why?
Blotting, Northern
3
1997
204
0.040
Why?
DNA Repair
2
2013
255
0.040
Why?
Acetylation
1
2022
252
0.040
Why?
Middle Aged
6
2020
35762
0.040
Why?
DNA Damage
2
2013
428
0.040
Why?
Repressor Proteins
1
2004
437
0.040
Why?
Radioimmunoassay
8
1993
165
0.040
Why?
Histone Deacetylases
1
2022
210
0.040
Why?
Aged
5
2020
25850
0.040
Why?
Bortezomib
2
2011
55
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
63
0.040
Why?
Maximum Tolerated Dose
1
2020
212
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
39
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
139
0.040
Why?
Blotting, Western
3
2010
1187
0.040
Why?
Gene Expression
3
1993
1487
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
24
0.040
Why?
Azetidines
1
2018
44
0.040
Why?
Lymphocytes
2
1991
382
0.040
Why?
Spleen
2
1991
508
0.030
Why?
GTP Phosphohydrolases
1
2018
93
0.030
Why?
4-Aminobenzoic Acid
1
2018
8
0.030
Why?
Nausea
1
2018
111
0.030
Why?
HCT116 Cells
1
2018
78
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
850
0.030
Why?
Okadaic Acid
1
1997
15
0.030
Why?
Orchiectomy
4
1994
74
0.030
Why?
Colforsin
1
1997
48
0.030
Why?
Mutagenesis, Site-Directed
2
2011
381
0.030
Why?
Diarrhea
1
2018
192
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2026
0.030
Why?
Piperidines
1
2018
217
0.030
Why?
Angiogenesis Inhibitors
1
2018
236
0.030
Why?
Cells, Cultured
4
2013
4146
0.030
Why?
Tumor Burden
1
2018
319
0.030
Why?
Histones
1
2022
668
0.030
Why?
Ubiquitination
1
2016
118
0.030
Why?
Heterografts
1
2016
143
0.030
Why?
Protein Isoforms
1
2017
402
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
112
0.030
Why?
Cetuximab
1
2016
111
0.030
Why?
Cell Differentiation
1
2004
2048
0.030
Why?
Fatigue
1
2018
361
0.030
Why?
Gene Rearrangement
1
2017
155
0.030
Why?
Administration, Oral
1
2018
847
0.030
Why?
Camptothecin
1
2016
140
0.030
Why?
Treatment Outcome
1
2010
11643
0.030
Why?
Models, Educational
1
2015
88
0.030
Why?
Capacity Building
1
2015
58
0.030
Why?
Polymerase Chain Reaction
3
1993
1054
0.030
Why?
DNA Copy Number Variations
1
2016
183
0.030
Why?
Diphenylamine
1
2014
8
0.030
Why?
DNA Mutational Analysis
1
2016
405
0.030
Why?
Biopsy
1
2018
1075
0.030
Why?
Follicle Stimulating Hormone
2
1993
249
0.030
Why?
Databases, Genetic
1
2015
248
0.030
Why?
Interdisciplinary Communication
1
2015
197
0.030
Why?
Aged, 80 and over
2
2017
8243
0.030
Why?
Guanine
1
1994
87
0.030
Why?
Analysis of Variance
1
1997
1304
0.030
Why?
Methyltransferases
1
1994
74
0.030
Why?
Gonadotropins
1
1993
39
0.030
Why?
Neoplasm Metastasis
1
2016
688
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
Research Personnel
1
2015
183
0.030
Why?
Butadienes
1
2013
37
0.030
Why?
MAP Kinase Kinase 2
1
2013
29
0.030
Why?
Benzamides
1
2014
224
0.030
Why?
Program Development
1
2015
369
0.020
Why?
Mentors
1
2015
218
0.020
Why?
MAP Kinase Kinase 1
1
2013
71
0.020
Why?
Kinetics
2
2014
1627
0.020
Why?
Cell Cycle Checkpoints
1
2013
99
0.020
Why?
Oncogene Proteins, Viral
1
2013
20
0.020
Why?
Molecular Sequence Data
3
2011
2929
0.020
Why?
Adult
4
2018
40262
0.020
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
66
0.020
Why?
Melanocytes
1
2013
64
0.020
Why?
Cooperative Behavior
1
2015
462
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
66
0.020
Why?
Genes, Synthetic
1
2012
14
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
379
0.020
Why?
DNA, Neoplasm
1
2013
163
0.020
Why?
Drug Hypersensitivity
1
1993
90
0.020
Why?
Nitriles
1
2013
205
0.020
Why?
Mice, SCID
1
2013
369
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
69
0.020
Why?
Membrane Proteins
1
2018
1165
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Nuclear Localization Signals
1
2011
17
0.020
Why?
Precision Medicine
1
2016
456
0.020
Why?
Peptide Mapping
1
2011
63
0.020
Why?
Microscopy, Fluorescence
1
2013
416
0.020
Why?
Alcoholic Intoxication
1
1992
74
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
381
0.020
Why?
Calcium Signaling
1
2013
251
0.020
Why?
Amino Acid Motifs
1
2011
224
0.020
Why?
Colony-Forming Units Assay
1
2010
95
0.020
Why?
Amino Acid Substitution
1
2011
304
0.020
Why?
Culture Media, Conditioned
1
2010
111
0.020
Why?
Genes, ras
1
2010
96
0.020
Why?
Protein Transport
1
2011
441
0.020
Why?
Gene Dosage
1
2010
148
0.020
Why?
Ligands
1
2011
673
0.020
Why?
Hypertension
1
2018
1254
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
346
0.020
Why?
Structure-Activity Relationship
1
2010
567
0.020
Why?
Gene Knockdown Techniques
1
2010
336
0.020
Why?
Drug Combinations
1
2010
390
0.020
Why?
Prolactinoma
1
1989
13
0.020
Why?
Serum Albumin
1
1990
147
0.020
Why?
Protein Structure, Tertiary
1
2011
862
0.020
Why?
Immunohistochemistry
1
2013
1715
0.020
Why?
Transcriptome
1
2015
1044
0.020
Why?
Curriculum
1
2015
1057
0.020
Why?
Cell Communication
1
2010
324
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
629
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
436
0.020
Why?
Pregnanediones
1
1987
12
0.020
Why?
Rats, Sprague-Dawley
4
1994
2525
0.020
Why?
Follow-Up Studies
1
2017
5389
0.020
Why?
Amino Acid Sequence
1
2011
2154
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
981
0.020
Why?
Brain Chemistry
1
1987
116
0.020
Why?
Calcium
1
2013
1182
0.020
Why?
Sulfonamides
1
2011
580
0.020
Why?
Pituitary Neoplasms
1
1989
190
0.020
Why?
Anesthetics
1
1987
99
0.020
Why?
Estrogens
1
1989
380
0.010
Why?
Feasibility Studies
1
2010
1087
0.010
Why?
Flow Cytometry
1
2009
1172
0.010
Why?
Prostatic Neoplasms
1
2013
974
0.010
Why?
Indoles
1
2009
501
0.010
Why?
Models, Biological
1
2013
1820
0.010
Why?
Metabolomics
1
2011
726
0.010
Why?
Liver Neoplasms
1
2011
780
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
15
0.010
Why?
Epidermal Growth Factor
1
2004
171
0.010
Why?
Antisense Elements (Genetics)
1
2003
3
0.010
Why?
Collagenases
1
2003
22
0.010
Why?
Matrix Metalloproteinase 3
1
2003
27
0.010
Why?
Genetic Vectors
1
2004
337
0.010
Why?
Cell Adhesion
1
2004
454
0.010
Why?
Cytokines
1
2010
2061
0.010
Why?
Cell Division
1
2004
766
0.010
Why?
Trans-Activators
1
2004
405
0.010
Why?
HeLa Cells
1
2003
650
0.010
Why?
Brain
1
1992
2930
0.010
Why?
Potassium
2
1990
152
0.010
Why?
Base Sequence
2
1993
2187
0.010
Why?
Biological Assay
2
1990
127
0.010
Why?
Hypophysectomy
2
1987
15
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
13
0.010
Why?
Injections, Intraperitoneal
1
1994
116
0.010
Why?
Rats, Mutant Strains
1
1993
20
0.010
Why?
Thyrotropin
1
1994
118
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
35
0.010
Why?
Stress, Physiological
2
1987
453
0.010
Why?
Adrenocorticotropic Hormone
1
1994
147
0.010
Why?
Blotting, Southern
1
1992
85
0.010
Why?
Cyclic AMP
1
1992
208
0.010
Why?
Protein Kinase C
1
1992
252
0.010
Why?
Enzyme Activation
1
1992
765
0.010
Why?
RNA Splicing
1
1992
284
0.000
Why?
Cross Reactions
1
1990
130
0.000
Why?
Dinoprostone
1
1990
178
0.000
Why?
Bromocriptine
1
1989
31
0.000
Why?
Norepinephrine
1
1990
196
0.000
Why?
Naloxone
1
1990
132
0.000
Why?
Perfusion
1
1990
250
0.000
Why?
Rats, Inbred F344
1
1989
268
0.000
Why?
In Vitro Techniques
1
1990
1047
0.000
Why?
Depression, Chemical
1
1987
16
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
593
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Molecular Weight
1
1987
327
0.000
Why?
Dopamine
1
1990
283
0.000
Why?
Pancreas
1
1990
341
0.000
Why?
Drug Administration Schedule
1
1989
778
0.000
Why?
Cerebral Cortex
1
1990
464
0.000
Why?
Ketamine
1
1987
132
0.000
Why?
Restraint, Physical
1
1986
75
0.000
Why?
Alcoholism
1
1992
808
0.000
Why?
DNA
1
1991
1460
0.000
Why?
Kidney
1
1990
1495
0.000
Why?
Liver
1
1990
1884
0.000
Why?
Lung
1
1990
4108
0.000
Why?
Tentler's Networks
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