 Enzyme-Linked Immunosorbent Assay
"Enzyme-Linked Immunosorbent Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
| Descriptor ID |
D004797
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| MeSH Number(s) |
E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360
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| Concept/Terms |
Enzyme-Linked Immunosorbent Assay- Enzyme-Linked Immunosorbent Assay
- Assay, Enzyme-Linked Immunosorbent
- Assays, Enzyme-Linked Immunosorbent
- Enzyme Linked Immunosorbent Assay
- Enzyme-Linked Immunosorbent Assays
- Immunosorbent Assay, Enzyme-Linked
- Immunosorbent Assays, Enzyme-Linked
- ELISA
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Below are MeSH descriptors whose meaning is more general than "Enzyme-Linked Immunosorbent Assay".
Below are MeSH descriptors whose meaning is more specific than "Enzyme-Linked Immunosorbent Assay".
This graph shows the total number of publications written about "Enzyme-Linked Immunosorbent Assay" by people in this website by year, and whether "Enzyme-Linked Immunosorbent Assay" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 3 | 3 | | 1996 | 1 | 9 | 10 | | 1997 | 0 | 8 | 8 | | 1998 | 0 | 7 | 7 | | 1999 | 0 | 14 | 14 | | 2000 | 0 | 6 | 6 | | 2001 | 2 | 6 | 8 | | 2002 | 0 | 12 | 12 | | 2003 | 1 | 18 | 19 | | 2004 | 2 | 22 | 24 | | 2005 | 3 | 20 | 23 | | 2006 | 2 | 21 | 23 | | 2007 | 1 | 20 | 21 | | 2008 | 0 | 24 | 24 | | 2009 | 1 | 32 | 33 | | 2010 | 0 | 38 | 38 | | 2011 | 0 | 42 | 42 | | 2012 | 1 | 29 | 30 | | 2013 | 2 | 27 | 29 | | 2014 | 4 | 25 | 29 | | 2015 | 0 | 22 | 22 | | 2016 | 2 | 18 | 20 | | 2017 | 1 | 17 | 18 | | 2018 | 0 | 11 | 11 | | 2019 | 0 | 10 | 10 | | 2020 | 0 | 7 | 7 | | 2021 | 1 | 13 | 14 | | 2022 | 0 | 4 | 4 | | 2023 | 0 | 4 | 4 | | 2024 | 3 | 1 | 4 | | 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Enzyme-Linked Immunosorbent Assay" by people in Profiles.
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Dadelahi A, Walker BS, Banerjee D, Mahler M, Saadalla A, Nandakumar V. Is the 99th Percentile Cutoff Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome. J Appl Lab Med. 2025 May 02; 10(3):605-618.
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van Rossum M, Veuskens BRJ, Brouwer MC, van Mierlo G, Lucientes-Continente L, Goicoechea de Jorge E, Uzonyi B, Matola AT, J?zsi M, M?ller G, Meter-Arkema AM, Poppelaars F, Pauly D, Pouw RB, Toonen EJM. Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5. J Innate Immun. 2025; 17(1):226-243.
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Pimple SN, Pedler MG, Shieh B, Mandava A, McCourt E, Petrash JM. Human Breast Milk Enhances Cellular Proliferation in Cornea Wound Healing. Curr Eye Res. 2024 Nov; 49(11):1138-1144.
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Saadalla A, Novis CL, Banerjee D, Martins T, Holloway B, Ann Aure M, Mahler M, Nandakumar V. Comparative assessment of the diagnostic performances of particle-based multianalyte technology and commercial ELISA for antiphospholipid autoantibody testing. Clin Chim Acta. 2024 Aug 15; 562:119849.
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Li Y, Ettah U, Jacques S, Gaikwad H, Monte A, Dylla L, Guntupalli S, Moghimi SM, Simberg D. Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin. Mol Pharm. 2024 Jun 03; 21(6):3053-3060.
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Basurto L, Manuel-Apolinar L, Robledo A, O'Leary S, Mart?nez-Murillo C, Medina-Ort?z LI, Montes Osorio MG, Zarazua J, Balc?zar-Hern?ndez L, Anda-Garay JC. Thrombotic risk assessed by PAI-1 in patients with COVID-19: The influence of hyperglycemia and diabetes mellitus. Clin Investig Arterioscler. 2024 Jul-Aug; 36(4):201-209.
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Zhang XS, Bizzaro N, Tebo AE, Nandakumar V, Infantino M, Carbone T, Bossuyt X, Damoiseaux J. Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research. Immunol Res. 2024 06; 72(3):361-363.
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Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 11; 256:109801.
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Moore RE, Wang T, Duvvuri B, Feser ML, Deane KD, Solomon JJ, Nelson JL, Demoruelle MK, Lood C. Prediction of Erosive Disease Development by Antimitochondrial Antibodies in Rheumatoid Arthritis. Arthritis Rheumatol. 2023 06; 75(6):890-899.
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Jaskowski TD, Nandakumar V, Novis CL, Palmer M, Tebo AE. Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis. Clin Chim Acta. 2023 Feb 01; 540:117219.
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