 ras Proteins
"ras Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D018631
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| MeSH Number(s) |
D08.811.277.040.330.300.400.500 D12.644.360.525.500 D12.776.157.325.515.500 D12.776.476.525.500
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| Concept/Terms |
ras Proteins- ras Proteins
- ras GTPases
- GTPases, ras
- Gene Products, ras
- ras Gene Products
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Below are MeSH descriptors whose meaning is more general than "ras Proteins".
Below are MeSH descriptors whose meaning is more specific than "ras Proteins".
This graph shows the total number of publications written about "ras Proteins" by people in this website by year, and whether "ras Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 2 | 5 | | 1996 | 0 | 3 | 3 | | 1997 | 1 | 1 | 2 | | 1998 | 1 | 2 | 3 | | 2001 | 1 | 1 | 2 | | 2002 | 1 | 1 | 2 | | 2003 | 3 | 2 | 5 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 3 | 5 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 3 | 3 | | 2009 | 4 | 2 | 6 | | 2010 | 1 | 2 | 3 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 2 | 5 | | 2013 | 2 | 6 | 8 | | 2014 | 3 | 8 | 11 | | 2015 | 2 | 1 | 3 | | 2016 | 2 | 0 | 2 | | 2017 | 3 | 2 | 5 | | 2018 | 5 | 0 | 5 | | 2019 | 2 | 2 | 4 | | 2021 | 5 | 0 | 5 | | 2022 | 1 | 1 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "ras Proteins" by people in Profiles.
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Kent A, Yee Mon KJ, Hutchins Z, Putzel G, Zhigarev D, Grier A, Jia B, Kortlever RM, Barbet G, Evan GI, Blander JM. A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis. Nat Immunol. 2025 Jan; 26(1):53-67.
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McCombs AM, Armendariz JR, Falke JJ. Ras signaling mechanisms: New insights from single-molecule biophysics. Biophys J. 2024 10 01; 123(19):3277-3280.
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Fleming IR, Hannan JP, Swisher GH, Tesdahl CD, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ. Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements. Anal Biochem. 2023 02 15; 663:115019.
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Delogu AB, Limongelli G, Versacci P, Adorisio R, Kaski JP, Blandino R, Maiolo S, Monda E, Putotto C, De Rosa G, Chatfield KC, Gelb BD, Calcagni G. The heart in RASopathies. Am J Med Genet C Semin Med Genet. 2022 12; 190(4):440-451.
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Peri A, Greenstein E, Alon M, Pai JA, Dingjan T, Reich-Zeliger S, Barnea E, Barbolin C, Levy R, Arnedo-Pac C, Kalaora S, Dassa B, Feldmesser E, Shang P, Greenberg P, Levin Y, Benedek G, Levesque MP, Adams DJ, Lotem M, Wilmott JS, Scolyer RA, J?nsson GB, Admon A, Rosenberg SA, Cohen CJ, Niv MY, Lopez-Bigas N, Satpathy AT, Friedman N, Samuels Y. Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma. J Clin Invest. 2021 10 15; 131(20).
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Hannan JP, Swisher GH, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ. HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. Anal Biochem. 2021 10 15; 631:114338.
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Siu HWD, Tebbutt N, Chantrill L, Karapetis C, Steer C, Wilson K, Espinoza D, Bailey L, Yip S, Cuff J, Pavlakis N, Thavaneswaran S, Briscoe K, Srivastav R, Shannon J, Segelov E, Tie J, Caird S, Francesconi A, Price T, Wuttke M, Ladwa R, Sjoquist K, Burge M. MONARCC: a randomised phase II study of panitumumab monotherapy and panitumumab plus 5-fluorouracil as first-line therapy for RAS and BRAF wildtype metastatic colorectal cancer: a study by the Australasian Gastrointestinal Trials Group (AGITG). BMC Cancer. 2021 Aug 18; 21(1):932.
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Levin N, Paria BC, Vale NR, Yossef R, Lowery FJ, Parkhurst MR, Yu Z, Florentin M, Cafri G, Gartner JJ, Shindorf ML, Ngo LT, Ray S, Kim SP, Copeland AR, Robbins PF, Rosenberg SA. Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy. Clin Cancer Res. 2021 09 15; 27(18):5084-5095.
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Biayna J, Mazuelas H, Gel B, Terribas E, Dumbovic G, Rosas I, Fern?ndez-Rodriguez J, Blanco I, Castellanos E, Carri? M, Lazaro C, Serra E. Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation. Sci Rep. 2021 02 11; 11(1):3661.
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Swisher GH, Hannan JP, Cordaro NJ, Erbse AH, Falke JJ. Ras-guanine nucleotide complexes: A UV spectral deconvolution method to analyze protein concentration, nucleotide stoichiometry, and purity. Anal Biochem. 2021 04 01; 618:114066.
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