 Cyclin-Dependent Kinase Inhibitor p16
"Cyclin-Dependent Kinase Inhibitor p16" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
| Descriptor ID |
D019941
|
| MeSH Number(s) |
D12.644.360.225.200 D12.776.167.187.200 D12.776.476.225.200 D12.776.624.776.355.200
|
| Concept/Terms |
Cyclin-Dependent Kinase Inhibitor p16- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin Dependent Kinase Inhibitor p16
- CDKN2 Protein
- CDKN2A Protein
- MTS1 Protein
- p16INK4 Protein
- p16(INK4A)
- INK4A Protein
- Protein, INK4A
- Cyclin-Dependent Kinase Inhibitor-2A
- Cyclin Dependent Kinase Inhibitor 2A
- Multiple Tumor Suppressor-1
- Multiple Tumor Suppressor 1
- Cdk4-Associated Protein p16
- Cdk4 Associated Protein p16
- p16INK4A Protein
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p16".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p16".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p16" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p16" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 0 | 5 | 5 | | 1997 | 0 | 2 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 2 | 1 | 3 | | 2004 | 2 | 1 | 3 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 3 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 3 | 4 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 3 | 4 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p16" by people in Profiles.
-
Masugi Y, Takamatsu M, Tanaka M, Hara K, Inoue Y, Hamada T, Suzuki T, Arita J, Hirose Y, Kawaguchi Y, Nakai Y, Oba A, Sasahira N, Shimane G, Takeda T, Tateishi K, Uemura S, Fujishiro M, Hasegawa K, Kitago M, Takahashi Y, Ushiku T, Takeuchi K, Sakamoto M. Post-operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression. J Pathol Clin Res. 2023 09; 9(5):339-353.
-
Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K. Prevalence of human papillomavirus DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol. 2023 04; 24(4):403-414.
-
Wilde DC, Castro PD, Bera K, Lai S, Madabhushi A, Corredor G, Koyuncu C, Lewis JS, Lu C, Frederick MJ, Frederick AM, Haugen AE, Zevallos JP, Sturgis EM, Shi J, Huang AT, Hernandez DJ, Skinner HD, Kemnade JO, Yu W, Sikora AG, Sandulache VC. Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration. Mod Pathol. 2022 08; 35(8):1045-1054.
-
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021 Oct 29; 374(6567):eabb3420.
-
Deng MY, Sturm D, Pfaff E, Sill M, Stichel D, Balasubramanian GP, Tippelt S, Kramm C, Donson AM, Green AL, Jones C, Schittenhelm J, Ebinger M, Schuhmann MU, Jones BC, van Tilburg CM, Wittmann A, Golanov A, Ryzhova M, Ecker J, Milde T, Witt O, Sahm F, Reuss D, Sumerauer D, Zamecnik J, Korshunov A, von Deimling A, Pfister SM, Jones DTW. Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. Nat Commun. 2021 09 20; 12(1):5530.
-
Koyuncu CF, Lu C, Bera K, Zhang Z, Xu J, Toro P, Corredor G, Chute D, Fu P, Thorstad WL, Faraji F, Bishop JA, Mehrad M, Castro PD, Sikora AG, Thompson LD, Chernock RD, Lang Kuhs KA, Luo J, Sandulache V, Adelstein DJ, Koyfman S, Lewis JS, Madabhushi A. Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma. J Clin Invest. 2021 04 15; 131(8).
-
Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities. J Invest Dermatol. 2019 09; 139(9):1985-1992.e10.
-
Schwartz CJ, Hickman R, Zhang X, Galvao Neto A, Adler E. Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy. Int J Surg Pathol. 2019 Feb; 27(1):84-88.
-
Wolsky RJ, Harbour LN, Mirza KM, Montag AG, Gwin K. The Stem Cell-associated Transcription Factor SOX2 as a Diagnostic Marker of High-grade Squamous Intraepithelial Lesion of the Uterine Cervix in Comparison With p16 and Ki-67. Appl Immunohistochem Mol Morphol. 2018 Jul; 26(6):403-410.
-
Laetsch TW, Roy A, Xu L, Black JO, Coffin CM, Chi YY, Tian J, Spunt SL, Hawkins DS, Bridge JA, Parsons DW, Skapek SX. Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children's Oncology Group. Clin Cancer Res. 2018 08 15; 24(16):3888-3897.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|