 Gene Dosage
"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
| Descriptor ID |
D018628
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| MeSH Number(s) |
G05.380.350
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| Concept/Terms |
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
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Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in this website by year, and whether "Gene Dosage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 2 | 0 | 2 | | 2006 | 1 | 4 | 5 | | 2007 | 5 | 0 | 5 | | 2008 | 1 | 4 | 5 | | 2009 | 3 | 4 | 7 | | 2010 | 5 | 4 | 9 | | 2011 | 0 | 4 | 4 | | 2012 | 1 | 5 | 6 | | 2013 | 2 | 7 | 9 | | 2014 | 3 | 3 | 6 | | 2015 | 1 | 6 | 7 | | 2016 | 1 | 3 | 4 | | 2017 | 0 | 3 | 3 | | 2018 | 3 | 4 | 7 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 3 | 3 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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Wethekam LC, Moore JK. Tubulin isotype regulation maintains asymmetric requirement for a-tubulin over ?-tubulin. J Cell Biol. 2023 03 06; 222(3).
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Lovell JT, Sreedasyam A, Schranz ME, Wilson M, Carlson JW, Harkess A, Emms D, Goodstein DM, Schmutz J. GENESPACE tracks regions of interest and gene copy number variation across multiple genomes. Elife. 2022 09 09; 11.
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Ruhl AP, Jeffries N, Yang Y, Gutierrez OM, Muntner P, Naik RP, Pecker LH, Mott BT, Zakai NA, Safford MM, Lange LA, Winkler CA, Irvin MR, Cushman M, Ackerman HC. Alpha globin gene copy number and hypertension risk among Black Americans. PLoS One. 2022; 17(7):e0271031.
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Ruhl AP, Jeffries N, Yang Y, Naik RP, Patki A, Pecker LH, Mott BT, Zakai NA, Winkler CA, Kopp JB, Lange LA, Irvin MR, Gutierrez OM, Cushman M, Ackerman HC. Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans. J Am Soc Nephrol. 2022 01; 33(1):213-224.
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Marin WM, Dandekar R, Augusto DG, Yusufali T, Heyn B, Hofmann J, Lange V, Sauter J, Norman PJ, Hollenbach JA. High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING. PLoS Comput Biol. 2021 08; 17(8):e1008904.
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Bazzicalupo AL, Thomas M, Mason R, Branco S. Gene Copy Number Variation Does Not Reflect Structure or Environmental Selection in Two Recently Diverged California Populations of Suillus brevipes. G3 (Bethesda). 2020 12 03; 10(12):4591-4597.
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Newell F, Wilmott JS, Johansson PA, Nones K, Addala V, Mukhopadhyay P, Broit N, Amato CM, Van Gulick R, Kazakoff SH, Patch AM, Koufariotis LT, Lakis V, Leonard C, Wood S, Holmes O, Xu Q, Lewis K, Medina T, Gonzalez R, Saw RPM, Spillane AJ, Stretch JR, Rawson RV, Ferguson PM, Dodds TJ, Thompson JF, Long GV, Levesque MP, Robinson WA, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Hayward NK. Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity. Nat Commun. 2020 10 16; 11(1):5259.
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Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, Kopan R. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biol. 2020 10; 18(10):e3000850.
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Oeyen JP, Baa-Puyoulet P, Benoit JB, Beukeboom LW, Bornberg-Bauer E, Buttstedt A, Calevro F, Cash EI, Chao H, Charles H, Chen MM, Childers C, Cridge AG, Dearden P, Dinh H, Doddapaneni HV, Dolan A, Donath A, Dowling D, Dugan S, Duncan E, Elpidina EN, Friedrich M, Geuverink E, Gibson JD, Grath S, Grimmelikhuijzen CJP, Gro?e-Wilde E, Gudobba C, Han Y, Hansson BS, Hauser F, Hughes DST, Ioannidis P, Jacquin-Joly E, Jennings EC, Jones JW, Klasberg S, Lee SL, Lesn? P, Lovegrove M, Martin S, Martynov AG, Mayer C, Montagn? N, Moris VC, Munoz-Torres M, Murali SC, Muzny DM, Oppert B, Parisot N, Pauli T, Peters RS, Petersen M, Pick C, Persyn E, Podsiadlowski L, Poelchau MF, Provataris P, Qu J, Reijnders MJMF, von Reumont BM, Rosendale AJ, Simao FA, Skelly J, Sotiropoulos AG, Stahl AL, Sumitani M, Szuter EM, Tidswell O, Tsitlakidis E, Vedder L, Waterhouse RM, Werren JH, Wilbrandt J, Worley KC, Yamamoto DS, van de Zande L, Zdobnov EM, Ziesmann T, Gibbs RA, Richards S, Hatakeyama M, Misof B, Niehuis O. Sawfly Genomes Reveal Evolutionary Acquisitions That Fostered the Mega-Radiation of Parasitoid and Eusocial Hymenoptera. Genome Biol Evol. 2020 07 01; 12(7):1099-1188.
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Burnaevskiy N, Sands B, Yun S, Tedesco PM, Johnson TE, Kaeberlein M, Brent R, Mendenhall A. Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins. Nat Commun. 2019 12 16; 10(1):5725.
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