 Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
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| MeSH Number(s) |
G02.111.830 G07.690.773.997
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| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
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Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 6 | 6 | | 1996 | 0 | 12 | 12 | | 1997 | 0 | 7 | 7 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 8 | 8 | | 2000 | 0 | 10 | 10 | | 2001 | 0 | 8 | 8 | | 2002 | 0 | 20 | 20 | | 2003 | 0 | 11 | 11 | | 2004 | 0 | 12 | 12 | | 2005 | 0 | 9 | 9 | | 2006 | 0 | 17 | 17 | | 2007 | 0 | 17 | 17 | | 2008 | 0 | 9 | 9 | | 2009 | 0 | 13 | 13 | | 2010 | 0 | 11 | 11 | | 2011 | 0 | 20 | 20 | | 2012 | 0 | 19 | 19 | | 2013 | 0 | 12 | 12 | | 2014 | 0 | 8 | 8 | | 2015 | 0 | 13 | 13 | | 2016 | 1 | 15 | 16 | | 2017 | 1 | 16 | 17 | | 2018 | 0 | 21 | 21 | | 2019 | 0 | 20 | 20 | | 2020 | 0 | 16 | 16 | | 2021 | 0 | 16 | 16 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 4 | 4 | | 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, C?t? J, Shi X, Zhou MM, Kutateladze TG. Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Nat Commun. 2025 Mar 06; 16(1):2235.
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Jutabha P, Kumar V, Anzai N, Rice PJ, Lightner JW, Endou H, Wempe MF. Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies. Drug Des Devel Ther. 2025; 19:1377-1392.
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Garzan A, Ahmed SK, Haese NN, Sulgey G, Medica S, Smith JL, Zhang S, Ahmad F, Karyakarte S, Rasmussen L, DeFilippis V, Tekwani B, Bostwick R, Suto MJ, Hirsch AJ, Morrison TE, Heise MT, Augelli-Szafran CE, Streblow DN, Pathak AK, Moukha-Chafiq O. 4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses. J Med Chem. 2024 Dec 12; 67(23):20858-20878.
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Harris SL, Dutta S, Liu N, Wollenberg T, Wang X. Extended structure-activity relationship studies of the [1,2,5]oxadiazolo[3,4-b]pyrazine-containing colistin adjuvants. Bioorg Med Chem Lett. 2025 Jan 01; 115:130008.
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Stokes EG, Kim H, Ko J, Aoto J. A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3a Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses. J Neurosci. 2024 Oct 09; 44(41).
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Gardner L, Rossi J, Armstrong B, Muse M, LaVeck A, Blevins MA, Zhang L, Ford HL, Zhao R, Wang X. Rational Design of Novel Allosteric EYA2 Inhibitors as Potential Therapeutics for Multiple Brain Cancers. ChemMedChem. 2024 Sep 16; 19(18):e202400179.
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Cele N, Awolade P, Seboletswe P, Khubone L, Olofinsan K, Islam MS, Jordaan A, Warner DF, Singh P. Synthesis,Antidiabetic and Antitubercular Evaluation of Quinoline-pyrazolopyrimidine hybrids and Quinoline-4-Arylamines. ChemistryOpen. 2024 Sep; 13(9):e202400014.
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Weig AW, O'Conner PM, Kwiecinski JM, Marciano OM, Nunag A, Gutierrez AT, Melander RJ, Horswill AR, Melander C. A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in Staphylococcus aureus. Org Biomol Chem. 2023 04 26; 21(16):3373-3380.
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El-Khouly OA, Henen MA, El-Sayed MA, El-Messery SM. Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. Sci Rep. 2022 10 12; 12(1):17104.
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Nashaat S, Henen MA, El-Messery SM, Eisa H. New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies. Molecules. 2022 Aug 17; 27(16).
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