Mitochondria
"Mitochondria" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
| Descriptor ID |
D008928
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| MeSH Number(s) |
A11.284.430.214.190.875.564 A11.284.835.626
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| Concept/Terms |
Mitochondrial Contraction- Mitochondrial Contraction
- Contraction, Mitochondrial
- Contractions, Mitochondrial
- Mitochondrial Contractions
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Below are MeSH descriptors whose meaning is more general than "Mitochondria".
Below are MeSH descriptors whose meaning is more specific than "Mitochondria".
This graph shows the total number of publications written about "Mitochondria" by people in this website by year, and whether "Mitochondria" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 1 | 4 | | 1996 | 3 | 3 | 6 | | 1997 | 0 | 1 | 1 | | 1998 | 3 | 0 | 3 | | 1999 | 5 | 1 | 6 | | 2000 | 6 | 4 | 10 | | 2001 | 3 | 3 | 6 | | 2002 | 5 | 6 | 11 | | 2003 | 6 | 3 | 9 | | 2004 | 10 | 8 | 18 | | 2005 | 7 | 10 | 17 | | 2006 | 10 | 4 | 14 | | 2007 | 5 | 11 | 16 | | 2008 | 11 | 15 | 26 | | 2009 | 8 | 7 | 15 | | 2010 | 10 | 5 | 15 | | 2011 | 14 | 5 | 19 | | 2012 | 21 | 9 | 30 | | 2013 | 19 | 11 | 30 | | 2014 | 17 | 12 | 29 | | 2015 | 24 | 11 | 35 | | 2016 | 21 | 11 | 32 | | 2017 | 15 | 20 | 35 | | 2018 | 18 | 26 | 44 | | 2019 | 17 | 9 | 26 | | 2020 | 18 | 17 | 35 | | 2021 | 21 | 20 | 41 | | 2022 | 4 | 18 | 22 | | 2023 | 3 | 14 | 17 | | 2024 | 21 | 8 | 29 | | 2025 | 11 | 17 | 28 |
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Below are the most recent publications written about "Mitochondria" by people in Profiles.
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Affandi T, Ohm AM, Speidel JT, Caino MC, Boulton DP, Reyland ME. PKCd Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response. Mol Cancer Res. 2025 Sep 04; 23(9):779-791.
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Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T. Evidence that mitochondria in macrophages are destroyed by microautophagy. Nat Commun. 2025 Aug 30; 16(1):8123.
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Matthews AM, Whiteley AM. UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential. Biochem Soc Trans. 2025 Aug 29; 53(4):823-833.
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Fielder SM, Friederich MW, Hock DH, Zhang JR, Valin LM, Rosenfeld JA, Booth KTA, Brown NJ, Rius R, Sharma T, Semcesen LN, Worley KC, Burrage LC, Treat K, Samson T, Govert S, DaCunha S, Yuan W, Chen J, Lesinski J, Hoang H, Morrison SA, Ladha FA, Van Hove RA, Michel CR, Reisdorph R, Tycksen E, Baldridge D, Silverman GA, Soler-Alfonso C, Conboy E, Vetrini F, Emrick L, Craigen WJ, Sykes SM, Stroud DA, Van Hove JLK, Schedl T, Pak SC. Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders. EMBO Mol Med. 2025 Oct; 17(10):2562-2585.
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Chattopadhyay M, Jenkins EC, Janssen W, Mashaka T, Germain D. Differential ER stress responses during lactation and postpartum outcomes in mice depending on their mitochondrial genotype. Nat Commun. 2025 Jul 11; 16(1):6432.
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Tegtmeyer M, Liyanage D, Han Y, Hebert KB, Pei R, Way GP, Ryder PV, Hawes D, Tromans-Coia C, Cimini BA, Carpenter AE, Singh S, Nehme R. Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion. Nat Commun. 2025 Jul 09; 16(1):6332.
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Skuli SJ, Bakayoko A, Kruidenier M, Manning B, Pammer P, Salimov A, Riley O, Brake-Sillá G, Dopkin D, Bowman M, Martinez-Gutierrez LN, Anderson CC, Reisz JA, Buono R, Paul M, Saland E, Liccardo F, DeVine A, Wong S, Xu JP, Nee E, Hausler R, Boettcher S, Sebti SM, Lai C, Maxwell KN, Sarry JE, Fruman DA, D'Alessandro A, Mesaros C, Keith B, Simon MC, Sung PJ, Wertheim G, Skuli N, Bowman RL, Matthews A, Carroll M. Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response. Leukemia. 2025 Sep; 39(9):2087-2098.
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Emaus KJ, Fogo GM, Wider JM, Sanderson TH. The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury. Cell Death Dis. 2025 Jul 05; 16(1):494.
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Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight. 2025 Aug 08; 10(15).
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Antonicka H, Weraarpachai W, Szigety KM, Kopajtich R, Gibson JB, Van Hove JLK, Friederich MW, Lopriore P, Neuhofer C, Van Hove RA, Cole MA, Reisdorph R, Peterson JT, Dempsey KJ, Ganetzky RD, Mancuso M, Prokisch H, Shoubridge EA. Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome. Am J Hum Genet. 2025 Jul 03; 112(7):1699-1710.
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