 eIF-2 Kinase
"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
| Descriptor ID |
D019892
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| MeSH Number(s) |
D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
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| Concept/Terms |
eIF-2 Kinase- eIF-2 Kinase
- Kinase, eIF-2
- eIF 2 Kinase
- DAI Protein Kinase
- Kinase, DAI Protein
- Protein Kinase, DAI
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- Inhibitor, dsRNA-Activated
- dsRNA Activated Inhibitor
- DSRNA-Dep Protein Kinase
- DSRNA Dep Protein Kinase
- Kinase, DSRNA-Dep Protein
- Protein Kinase, DSRNA-Dep
- eIF-2alpha Kinase
- Kinase, eIF-2alpha
- eIF 2alpha Kinase
- eRF, eIF-2 Recycling Factor
- eRF, eIF 2 Recycling Factor
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Controlled Repressor, Heme
- Repressor, Heme Controlled
- Heme-Controlled Inhibitor
- Heme Controlled Inhibitor
- Inhibitor, Heme-Controlled
- Heme-Regulated eIF-2alpha Kinase
- Heme Regulated eIF 2alpha Kinase
- Kinase, Heme-Regulated eIF-2alpha
- eIF-2alpha Kinase, Heme-Regulated
- Hemin Controlled Repressor
- Controlled Repressor, Hemin
- Repressor, Hemin Controlled
- p68 Kinase
- Kinase, p68
- Self-Phosphorylating Protein Kinase
- Kinase, Self-Phosphorylating Protein
- Protein Kinase, Self-Phosphorylating
- Self Phosphorylating Protein Kinase
- TIK Kinase
- Kinase, TIK
- P68 Protein Kinase
- Kinase, P68 Protein
- Protein Kinase, P68
- RNA-Dependent Protein Kinase
- Kinase, RNA-Dependent Protein
- Protein Kinase, RNA-Dependent
- RNA Dependent Protein Kinase
- p65 Kinase
- Kinase, p65
- Protein Kinase PKR
- Kinase PKR, Protein
- PKR, Protein Kinase
- Protein Kinase, RNA Activated
- Heme-Controlled Translational Repressor
- Heme Controlled Translational Repressor
- Repressor, Heme-Controlled Translational
- Translational Repressor, Heme-Controlled
- Hemin-Controlled Translational Repressor
- Hemin Controlled Translational Repressor
- Repressor, Hemin-Controlled Translational
- Translational Repressor, Hemin-Controlled
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Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".
This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.
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Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A. Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease. JCI Insight. 2024 Sep 05; 9(19).
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Valencia-Sanchez S, Davis M, Martensen J, Hoeffer C, Link C, Opp MR. Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice. Brain Behav Immun. 2024 Oct; 121:74-86.
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Murthy A, Rodriguez LR, Dimopoulos T, Bui S, Iyer S, Chavez K, Tomer Y, Abraham V, Cooper C, Renner DM, Katzen JB, Bentley ID, Ghadiali SN, Englert JA, Weiss SR, Beers MF. Activation of alveolar epithelial ER stress by ?-coronavirus infection disrupts surfactant homeostasis in mice: implications for COVID-19 respiratory failure. Am J Physiol Lung Cell Mol Physiol. 2024 Aug 01; 327(2):L232-L249.
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Subramanian K, Paul S, Libby A, Patterson J, Arterbery A, Knight J, Castaldi C, Wang G, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Kroemer A, Fishbein T, Mason A, Dominguez-Villar M, Mariappan M, Ekong UD. HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction. J Immunol. 2023 03 15; 210(6):732-744.
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Corbet GA, Burke JM, Bublitz GR, Tay JW, Parker R. dsRNA-induced condensation of antiviral proteins modulates PKR activity. Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2204235119.
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Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, Preisinger C, Wilhelm T, Huber M, Tirosh B. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020 03 11; 11(1):1304.
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The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020 02 07; 9(2).
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Capasso A, Bagby SM, Dailey KL, Currimjee N, Yacob BW, Ionkina A, Frank JG, Kim DJ, George C, Lee YB, Benaim E, Gittleman B, Hartman SJ, Tan AC, Kim J, Pitts TM, Eckhardt SG, Tentler JJ, Diamond JR. First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits ?-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer. Mol Cancer Ther. 2019 11; 18(11):1916-1925.
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Burke JM, Moon SL, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019 09 19; 75(6):1203-1217.e5.
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Mendez JM, Kolora LD, Lemon JS, Dupree SL, Keestra-Gounder AM. Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway. Infect Immun. 2019 08; 87(8).
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