 Phosphatidylinositol 3-Kinases
"Phosphatidylinositol 3-Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
| Descriptor ID |
D019869
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| MeSH Number(s) |
D08.811.913.696.620.500
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| Concept/Terms |
Phosphatidylinositol 3-Kinases- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol 3 Kinases
- Phosphoinositide 3-Hydroxykinase
- PI 3-Kinase
- PtdIns 3-Kinases
- 3-Kinases, PtdIns
- PtdIns 3 Kinases
- PI-3K
- PI3 Kinases
- Kinases, PI3
- PI3-Kinase
- PtdIns 3-Kinase
- Phosphatidylinositol-3-OH Kinase
- PI-3 Kinase
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 3-Kinases".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 3-Kinases".
This graph shows the total number of publications written about "Phosphatidylinositol 3-Kinases" by people in this website by year, and whether "Phosphatidylinositol 3-Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 | | 1997 | 0 | 2 | 2 | | 1999 | 0 | 4 | 4 | | 2000 | 2 | 1 | 3 | | 2001 | 5 | 2 | 7 | | 2002 | 2 | 5 | 7 | | 2003 | 4 | 4 | 8 | | 2004 | 4 | 6 | 10 | | 2005 | 2 | 5 | 7 | | 2006 | 5 | 6 | 11 | | 2007 | 5 | 8 | 13 | | 2008 | 8 | 6 | 14 | | 2009 | 7 | 4 | 11 | | 2010 | 5 | 7 | 12 | | 2011 | 2 | 9 | 11 | | 2012 | 4 | 10 | 14 | | 2013 | 5 | 10 | 15 | | 2014 | 3 | 11 | 14 | | 2015 | 3 | 12 | 15 | | 2016 | 4 | 7 | 11 | | 2017 | 3 | 8 | 11 | | 2018 | 2 | 6 | 8 | | 2019 | 2 | 2 | 4 | | 2020 | 4 | 5 | 9 | | 2021 | 0 | 1 | 1 | | 2022 | 1 | 17 | 18 | | 2023 | 2 | 5 | 7 | | 2024 | 3 | 3 | 6 | | 2025 | 1 | 0 | 1 | | 2026 | 2 | 0 | 2 |
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Below are the most recent publications written about "Phosphatidylinositol 3-Kinases" by people in Profiles.
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Fiske BE, Wemlinger SM, Crute BW, Getahun A. Lyn governs the establishment and maintenance of B cell anergy by suppressing PI3K signaling. Nat Commun. 2026 Mar 08; 17(1).
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Dermawan JK, Vanoli F, de Traux de Wardin H, Levi JN, Sanchez GI, Siddiquee A, Brosius S, You D, Tirode F, Sung P, Karanian M, Pissaloux D, Wexler LH, Kung A, Soragni A, Dela Cruz FS, Pavisic J, Antonescu CR. Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma. Sci Adv. 2026 Feb 27; 12(9):eaea6453.
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Scharf G, Davidson CR, Ustiyan V, Falkenberg LG, Adavalli A, Meeker JD, Morgan H, Ostmann AJ, Hudock KM, Brewington JJ, Clancy JP, Kramer EL. TGF-ß induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. Am J Physiol Lung Cell Mol Physiol. 2025 10 01; 329(4):L470-L479.
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Forman TE, Sajek MP, Larson ED, Mukherjee N, Fantauzzo KA. PDGFRa signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking. Elife. 2024 Dec 04; 13.
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Lyu C, Vaddi PK, Elshafae S, Pradeep A, Ma D, Chen S. Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development. Oncogene. 2025 02; 44(5):322-335.
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McCaleb MR, Miranda AM, Khammash HA, Torres RM, Pelanda R. Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion. Cell Rep. 2024 06 25; 43(6):114283.
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Farrell KB, Das S, Nordeen SK, Lambert JR, Thamm DH. VDX-111 targets proliferative pathways in canine cancer cell lines. PLoS One. 2024; 19(5):e0303470.
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Fiske BE, Getahun A. Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help. J Immunol. 2024 04 01; 212(7):1150-1160.
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Bhartiya P, Jaiswal A, Negi M, Kaushik N, Ha Choi E, Kumar Kaushik N. Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis. J Adv Res. 2025 Feb; 68:147-161.
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He F, Laranjeira AB, Kong T, Lin S, Ashworth KJ, Liu A, Lasky NM, Fisher DA, Cox MJ, Fulbright MC, Antunes-Heck L, Yu L, Brakhane M, Gao B, Sykes SM, D'Alessandro A, Di Paola J, Oh ST. Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms. J Clin Invest. 2024 Feb 01; 134(3).
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