 Glycoprotein Hormones, alpha Subunit
"Glycoprotein Hormones, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
| Descriptor ID |
D015292
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| MeSH Number(s) |
D06.472.699.322.326.562 D06.472.699.322.576.288.750 D06.472.699.322.576.463.249 D06.472.699.631.525.343.288.750 D06.472.699.631.525.343.463.249 D06.472.699.631.525.883.249 D06.472.699.649.367.562 D12.644.548.691.525.343.288.750 D12.644.548.691.525.343.463.249 D12.644.548.691.525.883.249 D12.644.548.726.367.562
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| Concept/Terms |
Glycoprotein Hormones, alpha Subunit- Glycoprotein Hormones, alpha Subunit
- Thyroid-Stimulating Hormone, alpha Subunit
- Thyroid Stimulating Hormone, alpha Subunit
- TSH-alpha
- TSH alpha
- ASGPH
- Chorionic Gonadotropin, alpha
- Chorionic Gonadotropin, alpha Subunit
- Common alpha Subunit Glycoprotein Hormones
- Follicle Stimulating Hormone, alpha Subunit
- Follicle-Stimulating Hormone, alpha Subunit
- FSH, alpha Subunit
- FSH-alpha
- FSH alpha
- Glycoprotein Hormones, alpha Chain
- Glycoprotein Hormones, alpha Polypeptide
- LH, alpha Subunit
- Luteinizing Hormone, alpha Subunit
- Lutotropin-alpha
- Lutotropin alpha
- Pituitary Glycoprotein Hormone, alpha Subunit
- Thyrotropin alpha Subunit
- TSH, alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "Glycoprotein Hormones, alpha Subunit".
- Chemicals and Drugs [D]
- Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
- Peptide Hormones [D06.472.699]
- Gonadotropins [D06.472.699.322]
- Chorionic Gonadotropin [D06.472.699.322.326]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.322.326.562]
- Gonadotropins, Pituitary [D06.472.699.322.576]
- Follicle Stimulating Hormone [D06.472.699.322.576.288]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.322.576.288.750]
- Luteinizing Hormone [D06.472.699.322.576.463]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.322.576.463.249]
- Pituitary Hormones [D06.472.699.631]
- Pituitary Hormones, Anterior [D06.472.699.631.525]
- Gonadotropins, Pituitary [D06.472.699.631.525.343]
- Follicle Stimulating Hormone [D06.472.699.631.525.343.288]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.631.525.343.288.750]
- Luteinizing Hormone [D06.472.699.631.525.343.463]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.631.525.343.463.249]
- Thyrotropin [D06.472.699.631.525.883]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.631.525.883.249]
- Placental Hormones [D06.472.699.649]
- Chorionic Gonadotropin [D06.472.699.649.367]
- Glycoprotein Hormones, alpha Subunit [D06.472.699.649.367.562]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Peptide Hormones [D12.644.548]
- Pituitary Hormones [D12.644.548.691]
- Pituitary Hormones, Anterior [D12.644.548.691.525]
- Gonadotropins, Pituitary [D12.644.548.691.525.343]
- Follicle Stimulating Hormone [D12.644.548.691.525.343.288]
- Glycoprotein Hormones, alpha Subunit [D12.644.548.691.525.343.288.750]
- Luteinizing Hormone [D12.644.548.691.525.343.463]
- Glycoprotein Hormones, alpha Subunit [D12.644.548.691.525.343.463.249]
- Thyrotropin [D12.644.548.691.525.883]
- Glycoprotein Hormones, alpha Subunit [D12.644.548.691.525.883.249]
- Placental Hormones [D12.644.548.726]
- Chorionic Gonadotropin [D12.644.548.726.367]
- Glycoprotein Hormones, alpha Subunit [D12.644.548.726.367.562]
Below are MeSH descriptors whose meaning is more specific than "Glycoprotein Hormones, alpha Subunit".
This graph shows the total number of publications written about "Glycoprotein Hormones, alpha Subunit" by people in this website by year, and whether "Glycoprotein Hormones, alpha Subunit" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1994 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1998 | 4 | 0 | 4 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Glycoprotein Hormones, alpha Subunit" by people in Profiles.
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Janssen JS, Sharma V, Pugazhenthi U, Sladek C, Wood WM, Haugen BR. A rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells. Mol Cell Endocrinol. 2011 Jun 06; 339(1-2):1-6.
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Jablonka-Shariff A, Kumar TR, Eklund J, Comstock A, Boime I. Single-chain, triple-domain gonadotropin analogs with disulfide bond mutations in the alpha-subunit elicit dual follitropin and lutropin activities in vivo. Mol Endocrinol. 2006 Jun; 20(6):1437-46.
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Sarapura VD, Wood WM, Woodmansee WW, Haakinson DJ, Dowding JM, Gordon DF, Ridgway EC. Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. Pituitary. 2006; 9(1):11-8.
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Kumar TR. What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice? Reproduction. 2005 Sep; 130(3):293-302.
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Kumar TR. Gonadotropin gene targeting and biological implications. Endocrine. 2005 Apr; 26(3):227-33.
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Matzuk MM, DeMayo FJ, Hadsell LA, Kumar TR. Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biol Reprod. 2003 Jul; 69(1):338-46.
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Brinkmeier ML, Stahl JH, Gordon DF, Ross BD, Sarapura VD, Dowding JM, Kendall SK, Lloyd RV, Ridgway EC, Camper SA. Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2. Mol Endocrinol. 2001 Dec; 15(12):2129-36.
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Sarapura VD, Strouth HL, Wood WM, Gordon DF, Ridgway EC. Activation of the glycoprotein hormone alpha-subunit gene promoter in thyrotropes. Mol Cell Endocrinol. 1998 Nov 25; 146(1-2):77-86.
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Wood WM, Dowding JM, Sarapura VD, McDermott MT, Gordon DF, Ridgway EC. Functional interactions of an upstream enhancer of the mouse glycoprotein hormone alpha-subunit gene with proximal promoter sequences. Mol Cell Endocrinol. 1998 Jul 25; 142(1-2):141-52.
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Brinkmeier ML, Gordon DF, Dowding JM, Saunders TL, Kendall SK, Sarapura VD, Wood WM, Ridgway EC, Camper SA. Cell-specific expression of the mouse glycoprotein hormone alpha-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells. Mol Endocrinol. 1998 May; 12(5):622-33.
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